ABILITY TO PREVENT AND TREAT THE CARDIOVASCULAR SYSTEM DAMAGES, CAUSED BY THE USE OF ANTI-CANCER DRUGS

Abstract


This review presents modern strategies for the prevention and treatment of cardiotoxicity induced by the most commonly used anticancer drugs such as anthracycline antibiotics, monoclonal antibodies, tyrosine kinase inhibitors. There are a large number of conflicting data on ways to overcome the cardiotoxicity of anticancer drugs. The creation of a complex of diagnostic measures will allow to identify the earliest signs of heart damage during chemotherapy and to develop timely preventive measures to prevent cardiotoxicity, improve the quality of life and prognosis of patients. Currently, a large number of small publications on the prevalence, prediction and prevention of cardiotoxicity in cancer patients, including the primary and secondary prevention of cardiotoxicity, are available. Beta-blockers and inhibitors of angiotensin-converting enzyme most often use as cardioprotective agents. There is evidence of poor tolerability of treatment with these drugs for young patients. Most drugs reduce blood pressure, which can adversely affect the health of patients without associated hypertension. Coordinated work between cardiologists and oncologists is needed to create common terminology, to define cardiovascular events and create registers, meta-analyzes, generally accepted recommendations, guidelines for the management of patients at risk of developing cardiotoxicity. This review used published articles the Scopus, Pubmed database, articles from The New England Journal of Medicine, Annals of Oncology, and periodicals of the Russian Federation over the past 10 years, as well as publications from previous years.

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About the authors

A. A Ibragimova

N.I. Pirogov Russian National Research Medical University

117997, Moscow, Russian Federation

E. I Emelina

N.I. Pirogov Russian National Research Medical University

117997, Moscow, Russian Federation

Gennady E. Gendlin

N.I. Pirogov Russian National Research Medical University

Email: rgmugt2@mail.ru
117997, Moscow, Russian Federation
doktor of medical sciences, professor, Department of Hospital Therapy №. 2 “N. I. Pirogov Russian National Research Medical University”; 117997, Moscow, Russian Federation

I. G Nikitin

N.I. Pirogov Russian National Research Medical University

117997, Moscow, Russian Federation

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