PECULIARITIES OF DIAGNOSIS OF TUBERCULOSIS IN HIV-INFECTED IN THE REPUBLIC OF KARELIA

Abstract


The features of clinical and radiological forms of tuberculosis (TB) and the informativeness of various methods of etiological diagnosis of TB among 175 patients with co-infected HIV + TB for the period 2001-2017 in the Republic of Karelia (RK) were studied. Timely execution of PCR diagnostics reliably reduces the likelihood of a lethal outcome in patients with a co-infection, as it made it possible to quickly detect not only the presence of MBT, but also determine multidrug resistance (MDR) and prescribe adequate chemotherapy on the first day of detection, which significantly reduces the risk of death. It was established that among patients with co-infection with HIV + pulmonary TB, decay cavities in the lung tissue were detected less frequently (40.7%), however, bacteria excretion was significantly more frequent (68.3%) than among patients with pulmonary TB in the Republic of Kazakhstan (data f.8).It has been established that improving the organization of sputum collection can significantly increase (by no less than 20%) the incidence of MBT in patients with pulmonary TB and HIV infection, which is important in the rapid diagnosis of TB and the appointment of adequate therapy, especially considering that among patients ½ (50.5%) co-infection of MBT had MDR.

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About the authors

Yu. M Markelov

Petrozavodsk State University, Department of Faculty Therapy, Phthisiology, Infectious Diseases and Epidemiology

185910, Petrozavodsk, Russian Federation

Ekaterina V. Pakhomova

Petrozavodsk State University, Department of Faculty Therapy, Phthisiology, Infectious Diseases and Epidemiology

Email: katrina15vladimirovna@mail.ru
185910, Petrozavodsk, Russian Federation
clinical intern, Petrozavodsk State University, 185910, Petrozavodsk, Russian Federation

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