Email this article Neurochemical study of the mechanism of action of thymus peptides in emotional stress
- Authors: Novoseletskaya A.V.1, Kiseleva N.M.2
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Affiliations:
- M.V. Lomonosov Moscow State University
- N.I. Pirogov Russian National Research Medical University
- Issue: Vol 26, No 4 (2020)
- Pages: 239–243
- Section: Clinical pharmacology and pharmaceuticals
- URL: https://medjrf.com/0869-2106/article/view/46601
- DOI: https://doi.org/10.17816/0869-2106-2020-26-4-239-243
- ID: 46601
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Abstract
A comparative study of the effect of the thymus hormone thymulin and thymus peptides (thymosin fraction 5) on the content of monoamines and their metabolites in the frontal cortex, striatum, adjacent nucleus, hypothalamus, hippocampus of the brain of Wistar rats, by high performance liquid chromatography, was performed. The hormone and peptides of the thymus were found to reduce emotional stress during functional impairment of the avoidance reaction and improved adaptation under stressful conditions in rats, which indicates the anti-stress effect of thymus hormones. The positive effect of the hormone and peptides of the thymus were manifested in a change in the balance of serotonin and norepinephrine in favor of the former in the hypothalamus and frontal cortex.
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About the authors
Anna V. Novoseletskaya
M.V. Lomonosov Moscow State University
Author for correspondence.
Email: kiseleva.67@mail.ru
MD, PhD
Russian Federation, MoscowNina M. Kiseleva
N.I. Pirogov Russian National Research Medical University
Email: kiseleva.67@mail.ru
ORCID iD: 0000-0003-1754-9051
doctor of biology, professor of the department of pharmacology of the faculty of Pediatrics “N.I. Pirogov Russian National Research Medical University”
Russian Federation, MoscowReferences
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