电邮这篇文章 Neurochemical study of the mechanism of action of thymus peptides in emotional stress
- 作者: Novoseletskaya A.V.1, Kiseleva N.M.2
-
隶属关系:
- M.V. Lomonosov Moscow State University
- N.I. Pirogov Russian National Research Medical University
- 期: 卷 26, 编号 4 (2020)
- 页面: 239-243
- 栏目: Clinical pharmacology and pharmaceuticals
- ##submission.dateSubmitted##: 09.10.2020
- ##submission.dateAccepted##: 09.10.2020
- ##submission.datePublished##: 09.10.2020
- URL: https://medjrf.com/0869-2106/article/view/46601
- DOI: https://doi.org/10.17816/0869-2106-2020-26-4-239-243
- ID: 46601
如何引用文章
开放存取
##reader.subscriptionAccessGranted##
详细
A comparative study of the effect of the thymus hormone thymulin and thymus peptides (thymosin fraction 5) on the content of monoamines and their metabolites in the frontal cortex, striatum, adjacent nucleus, hypothalamus, hippocampus of the brain of Wistar rats, by high performance liquid chromatography, was performed. The hormone and peptides of the thymus were found to reduce emotional stress during functional impairment of the avoidance reaction and improved adaptation under stressful conditions in rats, which indicates the anti-stress effect of thymus hormones. The positive effect of the hormone and peptides of the thymus were manifested in a change in the balance of serotonin and norepinephrine in favor of the former in the hypothalamus and frontal cortex.
全文:
作者简介
Anna Novoseletskaya
M.V. Lomonosov Moscow State University
编辑信件的主要联系方式.
Email: kiseleva.67@mail.ru
MD, PhD
俄罗斯联邦, MoscowNina Kiseleva
N.I. Pirogov Russian National Research Medical University
Email: kiseleva.67@mail.ru
ORCID iD: 0000-0003-1754-9051
doctor of biology, professor of the department of pharmacology of the faculty of Pediatrics “N.I. Pirogov Russian National Research Medical University”
俄罗斯联邦, Moscow参考
- Robson M.J., Quinlan M.A., Blakely R.D. Immune system activation and depression: roles of serotonin in the central nervous system and periphery. ACS Chem Neurosci. 2017;8(5):932-42. doi: 10.1021/acschemneuro.6b00412.
- Roumier A., Béchade C., Maroteaux L. Serotonin and the immune system. In: Pilowsky P.M., ed. Serotonin: The Mediator That Spans Evolution. Cambridge: Academic Press; 2019:181-96. doi: 10.1016/B978-0-12-800050-2.00010-3.
- Negi N., Das B.K. CNS: not an immunoprivilaged site anymore but a virtual secondary lymphoid organ. Int Rev Immunol. 2018;37(1): 57-68. doi: 10.1080/08830185.2017.1357719.
- Novoseletskaya A.V., Kiseleva N.M., Inozemtsev A.N. Effect of thymic hormone thymuline to restore learning and memory in thymectomied animals. Rossiyskiy immunologicheskiy zhurnal. 2017;11(1): 79-83. (in Russian)
- Chiu W.C., Lu M.L., Chang C.C. Mental disorders and interferon nontreatment in hepatitis C virus infection — a population based cohort study. Psychiatry Investig. 2020;17(3):268-74. doi: 10.30773/pi.2019.0254.
- Miroshnichenko I.I., Kudrin V.S., Raevskiy K.S. The effect of carbidine, sulpiride and haloperidol on the content of monoamines and their metabolites in rat brain structures. Farmakologiya i toksikolo¬giya. 1988;51(2):26-9. (in Russian)
- Yumatov E.A. Systematic approach as a conceptual basis for the study of emotional stress. Vestnik Akademii meditsinskikh nauk SSSR. 1982;(2):63-9. (in Russian)
- Baraban J.M., Aghajanian G.K. Noradrenergic innervation ot serotoninergic neurons in the dorsal raphe: demonstration by electron microscopic autoradiography. Brain Res. 1981;204(1):1-11. doi: 10.1016/0006-8993(81)90646-6.
- Kiseleva N.M., Novoseletskaya A.V., Inozemtsev A.N., Kudrin V.S., Klodt P.M., Narkevich V.B. et al. The mechanism of action of thymus-derived polypeptide (T-activin) in experimental emotional stress model: a neurochemical study. Vestnik Rossiyskogo universiteta druzhby narodov. Seriya: Meditsina. 2011;(4):143-8. (in Russian)
- Kiseleva N.M., Novoseletskaya A.V., Inozemtsev A.N., Zimina I.V., Arion V.Ya. Peptides of thymus in the regulation of stress. Meditsinskiy akademicheskiy zhurnal. 2013;13(3):64-70. (in Russian)
- Novoseletskaya A.V., Kiseleva N.M., Zimina I.V., Belova O.V., Inozemtsev A.N., Arion V.Ya., Sergienko V.I. Stress-protective effect of thymus peptides. Byulleten’ eksperimental’noy biologii i meditsiny. 2014;158(12):623-5. (in Russian)
- Litvinova S.V., Kalyuzhnyy A.L., Inozemtsev A.N., Shul’govskiy V.V. The piracetam action to monoaminergic and endogenous opioid system interaction in rats with different sensitiveness to morphine. Narkologiya. 2007;6(3):12-20. (in Russian)
补充文件
