Vol 16, No 1 (2010)

After 3 weeks of treatment, 36 patients who were found to have X-ray signs of pneumonia (pulmonary infiltrative changes, fever, productive cough, weakness) were randomized into two equal groups (a study group and a control one). Antibacterial therapy was changed and continued by 77.7 and 55% of control and study group patients, respectively. The study group patients were additionally given intravenous infusions of 400 ml of ozonized sodium chloride solution (pO3) containing 1.6 мg/ ml of O3 twice weakly for 21 days. Blood ozonization considerably accelerated the resolution time of X-ray infiltrative changes so that they were undetectable in all the study group patients by week 4 while they were only in 61.1% of the control groups. Blood ozonization used in combination with antibiotics permitted achievement of a sputum negative reaction against Chlamydia and Mycoplasma 2-3 weeks earlier. Infusions of pO3 just after the first ozonization made it possible to eliminate a clinical sign of chronic infection, such as weakness, to accelerate productive cough relief by 10 days, and to halve the number of fever patients at week 2, as compared with the controls. Ozone therapy for protracted pneumonias substantially enhances the efficiency of antibiotic treatment.

Treatment for chronic venous insufficiency was performed in 174 patients with trophic disturbances (n = 92) and trophic ulcers (n = 82) of the lower extremities before the introduction of ultrasound diagnostic techniques (retrospective groups). This was made in 29 patients with trophic ulcers (a prospective group) in accordance with the data of duplex scanning and involved ulcer preparation by laser radiation, as well as correction of venous blood flow. In the immediate postoperative period, wound complications in the patients from the retrospective groups developed in 16.3 and 36.6% of cases, respectively. In those from the prospective group, these occurred in 6.95. Among the 82 patients from a retrospective group, recurring ulcers were diagnosed after 1-32 years in 19.5% of cases. In the late postoperative period, trophic ulcers were detected in 2.2% of patients with trophic ulcers of soft tissues. Following 1-10 years, there were no recurring ulcers in the patients from the prospective group.

The role of blood nitric oxide (NO) was studied in the newborn infants at increased perinatal risk (PR). Increased NO production should be considered as a compensatory-adjustment response aimed at preserving hemodynamic microcirculatory processes in the neonatal organs and systems. The interrelationship and correlation of disorders between the level of NO and the activity of NOS, NADPH nitroreductase, O2-, ONOO-, and superoxide dismutase form a common mechanism of the severity and progression of lesions in vital organs and systems and the related features of clinical symptomatology in full-term and preterm neonates at PR.

The paper provides a comparative analysis of the state-of-art inhalation apparatuses from the basic parameters along with a direct noninvasive assessment of inhalant deposition processes that reflect their efficiency, estimation of the informative value of these parameters in different groups of subjects, including medical workers, students, and patients.