Vol 19, No 5 (2013)

The article analyzes the results of implementation of informed voluntary consent of women for application of amnioscopy. It is demonstrated that timely applied examination facilitates the early identification of unfavorable course of pregnancy. This approach makes it possible to timely apply the complex of treatment measures and hence to better the perinatal outcomes.

The article analyzes the clinical symptoms and laboratory indicators applied in diagnostic of salpingoophoritis. The sample included 65 female patients with non-specific salpingoophoritis and in 32 healthy women. To rationalize the diagnostic process in these groups the informativity of main symptoms, total analysis of blood, levels of cytokines in blood, immunoglobulins in cervical vaginal mucus and products of lipids oxygenation in blood was analyzed. The most informative diagnostic parameters of salpingoophoritis are established. The net model of rational diagnostic of non-specific salpingoophoritis is developed using computer modeling. This model makes it possible to significantly diminish number of analyzed parameters without damage to diagnostic.

The article presents evaluation of dynamics of clinical metabolic indicators in patients after gastrectomy on account of cancer during two-year period of monitoring against the background of personalized diet with enteral feeding included. The monitoring was applied to 128 patients: 57 males and 71 females aged from 20 to 82 years and mean age 60.7±12.2 years. The analysis was applied to blood biochemistry, factual diet in domestic conditions, body composition, basal metabolism and quality of life during treatment process. Every patient received a prescription of personalized diet therapy based on the results of examination of corresponding dietary status. In case of indication needed a medicament therapy was prescribed too. The erosive reflux esophagitis, hypoferric anemia was revealed in 34% of patients and damping-syndrome in 40% of patients. Against the background of diet recommendations in most patients the mentioned post-surgery complications were leveled and decrease of body mass was prevented. It was achieved to increase the body mass up to 3-5 kg in 12% of patients. The positive dynamics was established concerning normalization of bowels evacuation and decrease of dyspepsia occurrences and weakness. The concentration of whole protein increased up to 70 g/l (p<0.05), iron - up to 16 mkmol/l, hemoglobin - up to 126±3.2 g/l, and hematocrit - up to 0.374±0.07 (p<0.05). The evaluation of dynamics of body composition the increase of all basic components was established. The analysis of basal metabolism established normal protein oxidation, increased fat oxidation, and decrease of velocity of carbohydrates oxidation. The results of survey using a focused questionnaire of the European Organization for Research and Treatment of Cancer (QLQ-C30 version 3.0) demonstrated in patients amelioration of general health conditions. The patients became more robust physically and mentally and their major complaints diminished. The personalized diet therapy with enteral feeding included promotes support of body mass, amelioration of clinical metabolic and quality of life in patients after gastrectomy.

The article presents the results of diagnostic and treatment of unrecognized lingering carriage of foreign bodies in bronchi of children hospitalized for examination with symptomatic of prolonged and chronic bronchopulmonary disease. The key position in diagnostic is bronchoscopy. This technique made it possible to extract foreign bodies of different origin from depth of airway. The sample consisted of 79 examined patients including 53 children were aged up to 3 years old (67%) and 14 children were aged from 4 to 6 years old (17.7%). The technique of rigid bronchoscopy is rationally applied under general anesthesia with oxygen artificial lung ventilation in injection mode.

The article deals with results of study of processes of peroxidation of lipids and antioxidant defense in 29 children born in parents suffering of diabetes mellitus type I. It is demonstrated that in these children antiradical defense is stronger than in children with diabetes mellitus type I. The reinforcement of antioxidant defense in children born in parents suffering of diabetes mellitus type Ican promote the activation of defense factors with the development of reactions of adaptive character. The foundation of human health is developed in childhood. The processes of formation of morphologic functional status of child, growth and differentiation of tissues mainly depend on presence of diseases and conditions and effect of metabolic processes.

The article discusses the actual issue of safety of patients during application of medicinal agents related to unpractical combination of medicinal agents which can result in decrease of effectiveness and safety of pharmacological therapy. The application of medicinal agents in potentially dangerous combinations is a serious clinical issue. According various researchers, the combinations of medicinal agents prescribed by physicians are potentially dangerous in 17-23%. The untoward reactions induced by interaction of prescribed medicinal agents are developed in 6-8% of patients. The detection and analysis of complications of medicinal therapy related to pharmaceutical interaction is the most actual and complicated task of pharmaceutical control. In case of analysis of information about untoward reactions the most important is the evaluation of degree of confidence of cause-and-effect relationship "untoward reactions-medicinal agents’ interaction". The evaluation of degree of confidence of cause-and-effect relationship "untoward reactions-medicinal agents interaction" is ultimately important stage of evaluation of information about untoward reactions organized in national and regional centers of monitoring of safety of pharmaceuticals in many countries and WHO center. In practice of Russian pharmaceuticals control the mentioned technique hitherto was not applied to evaluate interdependence between complications related to medicinal agents. As a result of this, the present study was targeted to assess the significance of standardized evaluation of degree of confidence of cause-and-effect relationship "untoward reactions-medicinal agents interaction" in the process of analysis of information from national database concerning untoward reactions. The scale of determination of evaluation of degree of confidence of cause-and-effect relationship "untoward reactions-medicinal agents’ interaction" was developed using modification of the Horn-Hamsen scale in accordance with study demands. The application of the scale of determination of evaluation of degree of confidence of cause-and-effect relationship "untoward reactions-medicinal agents’ interaction" makes it possible to receive more reliable data concerning interaction of preparations and to detect these interactions. The application of given scale can be useful in preparation of evidential publications about cases of medicinal agents interactions resulting in complications. This scale can be useful in assessment of already published cases especially the ones which did not passed thorough verification.

The article presents the literature review cocnerning a serious danger of propagation of dioxin compounds for human organism. In case of their ingress on skin a serious pathology occurs in form of chloracne involving into pathologic process the hepatobiliary system. The humoral immunity suppression is marked. The increment of activity of anti-inflammatory cytokines is noted. The development of embryo-toxic and mutagenic effects is increased. All these processes condition the formation of malignant neoplasms.