Доклады Академии наукДоклады Академии наук0869-5652The Russian Academy of Sciences1286310.31857/S0869-56524852247-250Research ArticlePhysical fatigue and the morfofunctional state of myocardium in experimental chronic stressKondashevskayaM. V.marivladiko@mail.ruTseylikmanV. E.marivladiko@mail.ruKomelkovaM. V.marivladiko@mail.ruLapshinM. S.marivladiko@mail.ruSarapultsevA. P.marivladiko@mail.ruLazukoS. S.marivladiko@mail.ruKuzhelO. P.marivladiko@mail.ruManukhinaE. B.marivladiko@mail.ruDowneyH. F.marivladiko@mail.ruChereshnevaM. V.marivladiko@mail.ruChereshnevV. A.<p>academician of the RAS</p>marivladiko@mail.ruResearch institute of human morphologySouth Ural State UniversityInstitute of Immunology and Physiology, Ural Branch of Russian Academy of SciencesUral Federal UniversityEducational Establishment Vitebsk State Order of Peoples' Friendship Medical UniversityInstitute Of General Pathology And PathophysiologyUniversity of North Texas Health Science Center2005201948522472502305201923052019Copyright © 2019, Russian academy of sciences2019<p>The relationship between skeletal muscle fatigue and morpho-functional alterations in the myocardium was analyzed for the first time in Wistar male rats exposed to chronic stress. Post traumatic stress disorder (PTSD) was associated with signs of increased oxidative stress, which apparently induced the changes in cardiomyocyte structural components and the acceleration of skeletal and muscular fatigue.</p>myocardiumoxidative stresspost-traumatic stress disorderPTSDheartmusculoskeletal fatigueмиокардоксидативный стресспросттравматическое стрессовое растройствоПТСРсердцескелетно-мышечная усталость[Edmondson D., von Kanel R. Post-Traumatic Stress Disorder and Cardiovascular Disease // Lancet Psych. 2017. V. 4. P. 320-329.][Pitman R.K., Rasmusson A. M., Koenen K. C., et al. Biological Studies of Post-Traumatic Stress Disorder // Nat. Rev. Neurosci. 2012. V. 13. P. 769-787.][Koenen K.C., Sumner J. A., Gilsanz P., et al. Post-Traumatic Stress Disorder and Cardiometabolic Disease: Improving Causal Inference to Inform Practice // Psychol. Med. 2017. V. 47. P. 209-225.][Oddone A.E., Dennis P. A., Calhoun P. S., et al. Orthostatic Hypotension in Young Adults with and without Posttraumatic Stress Disorder // Psychol. Trauma. 2015. V. 7. P. 229-233.][Ebner K., Singewald N. Individual Differences in Stress Susceptibility and Stress Inhibitory Mechanisms // Curr. Opin. Behav. Sci. 2017. V. 14. P. 54-64.][Zoladz P.R., Park C. R., Fleshner M., et al. Psychosocial Predator-Based Animal Model of PTSD Produces Physiological and Behavioral Sequelae and a Traumatic Memory Four Months Following Stress Onset // Physiol. Behav. 2015. V. 147. P. 183-192.][Sapolsky R.M., Romero L. M., Munck A. U. How Do Glucocorticoids Influence Stress Responses? Integrating Permissive, Suppressive, Stimulatory, and Preparative Actions // Endocr. Rev. 2000. V. 21. P. 55-89.][Lazuko S.S., Kuzhel O. P., Belyaeva L. E., Manukh- ina E. B., Fred Downey H., Tseilikman O. B., Komel- kova M. V., Tseilikman V. E. Posttraumatic Stress Disorder Disturbs Coronary Tone and Its Regulatory Mechanisms // Cell. Mol. Neurobiol. 2018. V. 38. P. 209-217.][Клиническая лабораторная аналитика. Т. II. Частные аналитические технологии в клинической лаборатории / Под ред. В.В. Меньшикова. М.: Лабинформ-РАМЛД, 1999. 352 с.][Волчегорский И.А., Долгушин И. И., Колесников О. Л., Цейликман В. Э. Экспериментальное моделирование и лабораторная оценка адаптационных реакций организма. Челябинск: Изд-во Челяб. гос. пед. ун-та, 2000. 167 с.][Дубинина Е.Е., Бурмистров С. О., Ходов Д. А., Поротов И. Г. Окислительная модификация белков сыворотки крови человека, метод ее определения // Вопр. мед. химии. 1995. Т. 41. № 1. С. 24-26.][Chandramouli C., Varma U., Stevens E. M., et al. Myocardial Glycogen Dynamics: New Perspectives on Disease Mechanisms // Clin. Exp. Pharmacol. Physiol. 2015. V. 42. P. 415-425.]