Доклады Академии наукДоклады Академии наук0869-5652The Russian Academy of Sciences1288910.31857/S0869-56524853370-373Research ArticleThe generation of the human mab RabD4 specific to the rabies virus glycoprotein and characterization thereofIlinaЕ. N.Ekaterina.iljina.7@yandex.ruSolopovaE. V.Ekaterina.iljina.7@yandex.ruAlievТ. К.Ekaterina.iljina.7@yandex.ruLarinaМ. V.Ekaterina.iljina.7@yandex.ruBalabashinD. S.Ekaterina.iljina.7@yandex.ruVarlamovN. Е.Ekaterina.iljina.7@yandex.ruDolgikhD. А.Ekaterina.iljina.7@yandex.ruSveshnikovP. G.Ekaterina.iljina.7@yandex.ruKirpichnikovМ. P.<p>academician of the RAS</p>Ekaterina.iljina.7@yandex.ruLomonosov Moscow State UniversityAll-Russian Scientific Center for Molecular Diagnostics and TreatmentShemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Science2105201948533703732305201923052019Copyright © 2019, Russian academy of sciences2019<p>We generated a novel human neutralizing human mAb RabD4 against rabies virus glycoprotein using in vitro stimulation human peripheral B cells produced from immunized donor. It was revealed that the human mAb RabD4 demonstrated high antigen-binding activity and virus-neutralizing activity in the FAVN test with the CVS-11 rabies virus.</p>rabies virusmonoclonal antibodiesglycoproteinFAVNpost-exposure prophylaxisвирус бешенствамоноклональные антителагликопротеинFAVNпостэкспозиционная профилактика[Fisher C. R., Streicker D. G., Schnell M. J. // Nature Rev. Microbiol. 2018. V. 16. P. 241-255.][Kohler G, Milstein C. // Nature. 1975. V. 256. P. 495-497.][Ilina E. N., Solopova O. N., Balabashin D. S., Larina M. V., Aliev T. K., Grebennikova T. V., Losich M. A., Zaykova O. N., Sveshnikov P. G., Dolgikh D. A., Kirpi- chnikov M. P. // Russ. J. Bioorg. Chem. 2019. V. 45. P. 1-11.][de Kruif J., Bakker A. B., Marissen W. E., Kramer R. A., Throsby M., Rupprecht C. E., Goudsmit J. // Annu. Rev. Med. 2007. V. 58. P. 359-368.][Laemmli U. K. // Nature. 1970. V. 227. P. 680-685.]