Доклады Академии наукДоклады Академии наук0869-5652The Russian Academy of Sciences1352610.31857/S0869-56524863384-388Research ArticleThe CYP443C1 (CYP74 clan) cytochrome of sea anemone Nematostella vectensis - the first Metazoan enzyme possessing hydroperoxide lyase / epoxyalcohol synthase activityGorinaS. S.gsvetlana87@gmail.comToporkovaY. Y.gsvetlana87@gmail.comMukhtarovaL. S.gsvetlana87@gmail.comGrechkinA. N.<p>Academician of the Russian Academy of Sciences</p>gsvetlana87@gmail.comKazan Institute of Biochemistry and Biophysics, Kazan Scientific Center, Russian Academy of Sciences3005201948633843881806201918062019Copyright © 2019, Russian academy of sciences2019<p>A novel CYP74 clan gene CYP443C1 of the starlet sea anemone (Nematostella vectensis, Cnidaria) has been cloned, and the properties of the corresponding recombinant protein have been studied. Depending on the substrate, CYP443C1 exhibited double function hydroperoxide lyase/epoxyalcohol synthase activity.</p>Nematostella vectensisCYP74 clanepoxyalcohol synthasehydroperoxide lyaseNematostella vectensisклан CYP74гидропероксидлиазаэпоксиалкогольсинтаза[Gerwick W.H., Moghaddam M., Hamberg M. // Arch. Biochem. Biophys. 1991 V. 290 P. 436-444.][Gabbs M., Leng S., Devassy J.G., Monirujjaman M., Aukema H.M. // Adv. Nutr. 2015. V. 6. P. 513-540.][Stumpe M., Feussner I. // Phytochem. Rev. 2005. P. 347-357.][Koeduka T., Ishizaki K., Mwenda C.M., Hori K., Sasaki-Sekimoto Y., Ohta H., Kohchi T., Matsui K. // Planta. 2015. V. 242. P. 1175-1186.][Toporkova Y.Y., Fatykhova V.S., Gogolev Y.V., Khairutdinov B.I., Mukhtarova L.S., Grechkin A.N. // Biochim. Biophys. Acta. 2017. V. 1761. P. 1419-1428. Lee D.-S., Nioche P., Hamberg M., Raman C.S. // Nature. 2008. V. 455, P. 363-370.][Toporkova Y.Y., Gorina S.S., Mukhitova F.K., Hamberg M., Ilyina T.M., Mukhtarova L.S., Grechkin A.N. // Biochim. Biophys. Acta. 2017. V. 1862. P. 1099-1109.][Mukhtarova L.S., Mukhitova F.K., Gogolev Y.V., Grechkin A.N. // Phytochemistry. 2011. V. 72. P. 356-364.][Toporkova Y.Y., Gorina S.S., Bessolitsyna E.K., Smirnova E.O., Fatykhova V.S., Brühlmann F., Ilyina T.M., Mukhtarova L.S., Grechkin A.N. // Biochim. Biophys. Acta. 2018. V. 1863. P. 369-378.][Grechkin A.N., Brühlmann F., Mukhtarova L.S., Gogolev Y.V., Hamberg M. // Biochim. Biophys. Acta. 2006. V. 1761. P. 1419-1428.][Teder T., Lõhelaid H., Boeglin W.E., Calcutt W.M., Brash A.R., Samel N. // J Biol Chem. 2015. V. 290. P. 19 823-19 832.]