Доклады Академии наукДоклады Академии наук0869-5652The Russian Academy of Sciences1432310.31857/S0869-56524855642-645Research ArticleUltrastructure and nanomorphology of the American mink (mustela vison) kidneyEzhkovV. O.egkova-am@mail.ruEzhkovaM. S.egkova-am@mail.ruYapparovI. A.egkova-am@mail.ruYapparovA. Kh.egkova-am@mail.ruNizameevI. R.egkova-am@mail.ruNefedievE. S.egkova-am@mail.ruEzhkovaA. M.egkova-am@mail.ruLarinaJu. V.egkova-am@mail.ruTatar Scientific Research Institute of Agrochemistry and Soil Science, «Kazan Scientific Center of the Russian Academy of Sciences»Kazan National Research Technological University2305201948556426452306201923062019Copyright © 2019, Russian academy of sciences2019<p class="a"><span lang="EN-US">The ultrastructure of the nephron subcellular organelles was studied in healthy mink kidneys. The data obtained were compared with the results of transmission electron microscopy. The renal cell nanomorphology proved to be similar when electronograms and the atomic force microscopy images were analyzed. The methods used enabled us to visualize the glomerular capillary endotheliocytes with cytolemma pits in the area of fenestrae that provide blood filtration; in the proximal nephron part, on the apical pole of the epithelial cells, brush-border soft microvilli were observed. The microvilli were characterized by a well-organized structure along their entire length and the membrane integrity. The data obtained show morphological parameters of the healthy mink organ and can be helpful in diagnosing of nephropathology.</span></p>kidneyultrastructurenanomorphologythe filter is the glomerulusa nephronthe American minkпочкаультраструктурананоморфологиягломерулярный фильтрнефроннорка американская[Физиология человека / Под ред. В. М. Покровского, Г. Ф. Коротько. М.: Медицина, 2003.][Павлович Е. Р. Проблемы изучения морфологии человека // Фунд. исслед. 2008. № 6. С. 107-108.][URL: www.msu.ru/bioetika/doc/recom.doc][Ежков В. О., Ежкова А. М., Яппаров А. Х., Яппаров И. А., Низамеев И. Р., Нефедьев Е. С. Опыт применения атомно-силовой микроскопии в морфологических исследованиях печени на примере норки американской // Рос. нанотехнологии. 2017. Т. 12. № 7/8. С. 107-113.][Schillers H., Medalsy I., Hu S., et al. PeakForce Tapping Resolves Individual Microvilli on Living Cells // J. Mol. Recogn. 2016. V. 29. № 2. P. 95-101.][Chiou Y. W., Lin H. K., Tang M. J., et al. The Influence of Physical and Physiological Cues on Atomic Force Microscopy-Based Cell Stiffness Assessment // PLoS One. 2013. V. 8. № 10. e77384.][Wyss H. M., Henderson J. M., Byfield F. J., et al. Biophysical Properties of Normal and Diseased Renal Glomeruli // Amer. J. Physiol. Cell Physiol. 2011. V. 300. № 3. P. 397-405.]