Доклады Академии наукДоклады Академии наук0869-5652The Russian Academy of Sciences1452610.31857/S0869-56524866742-747Research ArticleAnti-cancer activity of dinitrosyl iron complex (no donor) on the multiple myeloma cellsAkentievaN. P.na_aken@icp.ac.ruSaninaN. A.na_aken@icp.ac.ruPrichodchenkoT. R.na_aken@icp.ac.ruGizatullinA. R.na_aken@icp.ac.ruShkondinaN. I.na_aken@icp.ac.ruShushanovS. S.na_aken@icp.ac.ruStupinaT. S.na_aken@icp.ac.ruAldoshinS. M.<p>Academician Russian Academy of Sciences</p>na_aken@icp.ac.ruInstitute of Problem of Chemical Physics of the Russian Academy of ScienceScientific Center in Chernogolovka of the Russian Academy of SciencesLomonosov Moscow State UniversityFederal State Budgetary Scientific Institution «N.N.Blokhin Russian Cancer Research Center» of the Ministry of Health of the Russian Federation2806201948667427472806201928062019Copyright © 2019, Russian academy of sciences2019<p>The results of a study of the effect of a mononuclear dinitrosyl iron complex (DNIC7) with functional sulfur-containing ligands (NO donor) on the cell viability of multiple myeloma cells are presented. It has been shown that DNIC7 decreased cell viability and inhibited the proliferation of cells of multiple myeloma, i.e. possesses cytotoxic properties. Fluorescent analysis revealed that the DNIC7 compound lowers the level of intracellular glutathione and increases the level of reactive oxygen species in cells of multiple myeloma. It is assumed that DNIC7 has the therapeutic potential for the treatment of cancer.</p>cytotoxicitydinitrosyl iron complexdonor NOmultiple myelomaцитотоксичностьдинитрозильный комплекс железадонор NOмножественная миелома[Costa F., Das R., Kini Bailur J., Dhodapkar K., Dhodapkar M.V. // Front Immunol. 2018. V. 9. Article 2204. P. 1-11. DOI: 10.3389/fimmu.2018.02204.][Rigas B., Sun Y. // Brit. J. Cancer. 2008. V. 98. P. 1157-1160.][Scicinski J., Oronskya B., Ning S., Knox S., Peehl D., Kim M.M., Langeckere P., Fangera G. // Redox Biol. 2015. V. 6. P. 1-8.][Hirst D.G., Robson T. // Curr. Pharm. Des. 2010. V. 16. P. 45-55.][Maciag Anna E., Holland Ryan J., Cheng Y.-S. Robert, Rodriguez Luis G., Saavedra Joseph E., Anderson Lucy M., Keefer Larry K. // Redox Biology. 2013. V. 1. P. 115-124.][Akentieva N.P., Sanina N.A., Gizatullin A.R., Shmat¬ko N.Y., Goryachev N.S., Shkondina N.I., Prikhodchenko T.R., ¬Aldoshin S.M. // Doklady Biochemistry and Biophysics. 2017. V. 477. № 1. P. 389-393. DOI: 10.1134/S1607672917060126.][Sanina N.А., Aldoshin S.М., Shmatko N.Yu., Korcha¬gin D.V., Shilov G.V., Knyaz’kina Е.А., Ovanesyan N.S., Kulikov А.V. // New J. of Chem. 2015. V. 39. P. 1022-1030.][Венкатараман К. Химия синтетических красителей. Л.: Государственное научно-техническое издательство Химической литературы. 1956. Т. 1. 403 с.][Schreer A. , Tinson C., Sherry J.P., Schirmer K. // Anal. Biochem. 2005. V. 344. P. 76-85.][Ormerod M.G., Tribukait B., Giaretti W. // Anal. Cell. Pathol. 1998. V. 17. № 2. P. 103-110.][Oksvold M.P., Skarpen E., Widerberg J., Huitfeldt H.S.// J. Histochem. Cytochem. 2002. V. 50. P. 289-303.][Hissin P.J., Hilf R. // Anal. Biochem. 1976. V. 74. P. 214-226.][Калинина Е.В., Чернов Н.Н., Новичкова М.Д. // Успехи биол. химии. 2014. T. 54. C. 299-348.][Garcia-Gimenez J.L., Markovic J., Dasi F., Queval G., Schnaubelt D., Foyer C.H., Pallardo F.V. // Biochim. et Biophys. Acta. 2013. V. 1830. P. 3304-3316.][Cai Z., Yan L.J. // Journal of Biochem. and Pharmacol. Research. 2013. V. 1. P. 15-26.]