Доклады Академии наукДоклады Академии наук0869-5652The Russian Academy of Sciences1860210.31857/S0869-56524893313-317Research ArticleThe role of catecholamines in the development of pathological retina neovascularization in an experimental model of retinopathy of prematurity in ratsKatarginaL. A.zubova@gmail.comOsipovaN. A.zubova@gmail.comPanovaA. Y.zubova@gmail.comPetrovskayaA. V.zubova@gmail.comNikishinaY. O.zubova@gmail.comMurtazinaA. R.zubova@gmail.comUgrumovM. V.<p>Academician of the Russian Academy of Sciences</p>zubova@gmail.comHelmholtz National Medical Research Center of Eye Diseases Ministry of Health of the Russian FederationHelmholtz National Medical Research Center of Eye Diseases, Ministry of Health of the Russian FederationKoltsov Institute of Developmental Biology, Russian Academy of Sciences2911201948933133170912201909122019Copyright © 2019, Russian academy of sciences2019<p class="a"><span lang="EN-US">This work is dedicated to prove our hypothesis that catecholamines and their metabolites play crucial role in development of retinopathy of prematurity, severe disabling fibrovasoproliferative vitreoretinal pathology of premature infants. Research was done on experimental model of retinopathy achieved by hyperohygenation in rats on 7th, 14th, 21st and 30th day of life. Amount of catecholamines and their metabolites in retina of rats was measured by HPLC with electrochemical detection. It was shown that L-DOPA on 21st and 30th day of life were lowered in model animals than in control and noradrenaline on 14 th day increased in model animals than in control. However we did not observed dopamine changes between experimental model and control. Given the literature data on cathecholamines and their role in regulation of vasculogenesis in retina, our data shows that changes in cathecholamine metabolism play crucial role in pathology of this severe illness.</span></p>catecholaminesratretinopathy of prematurityкатехоламиныкрысаретинопатия недоношенных[Chakroborty D., Sarkar C., Yu H., et al. // PNAS. 2011. V. 108. № 51. P. 20 730-20 735. DOI: 10.1073/pnas.1108696108.][Moreno-Smith M., Lutgendorf S.K., Sood A.K. // Future Oncol. 2010. V. 6. № 12. P. 1863-1881.][Dvorak H.F. // J. Thromb. Haemost. 2005. V. 3. № 8. P. 1835-1842.][Hadjiconstantinou M., Neff N.H. // Life Sciences. 1984. V. 35. № 11. P. 1135-1147.][Катаргина Л.А., Хорошилова-Маслова И.П., Майбогин А.М. и др. // Межд. журн. прикладных и фундаментальных иссл. 2017. Т. 3. C. 190-194.][Witkovsky P., Arango Gonzalez B., Haycock J.W., et al. // J. Comp. Neurol. 2005. V. 481. № 4. P. 352-362.][Spix N.J., Liu L.L., Zhang Z., et al. // Invest Ophthalmol. Vis. Sci. 2016. V. 57. № 7. P. 3047-3057.][Zhang N., Favazza T.L., Baglieri A.M., et al. // Invest. Ophthalmol. Vis. Sci. 2013. V. 54. № 13. P. 8275-8284.][Lopez V.M., Decatur C.L., Stamer W.D., et al. // PLoS Boil. 2008. V. 6. № 9. P. 236.][Falk T., Congrove N.R., Zhang S., et al. // J. Biomed. Biotechnol. 2012. V. 2012.][Dal Monte M., Cammalleri M., Mattei E., et al. // Invest. Ophthalmol. Vis. Sci. 2015. V. 56. № 1. P. 59-73.][Makhoul I.R., Peleg O., Miller B., et al. // Arch. Dis. Child. 2013. V. 98. P. 565-567.][Shelke R.R., Lakshmana M.K., Ramamohan Y., et al. // Int J. Dev. Neurosci. 1997. V. 15. № 1. P. 139-143.]