Herald of the Russian Academy of SciencesHerald of the Russian Academy of SciencesВестник Российской академии наук0869-58733034-5200The Russian Academy of Sciences65954710.31857/S086958732309013XBBQGDNТЕМАТИЧЕСКИЙ ВЫПУСК ПО БИОЛОГИИGENE TAG7 AND ITS TRANSCRIPT TAG7 PROTEIN: PERSPECTIVES OF MEDICAL APPLICATIONSГЕН TAG7 И ЕГО ПРОДУКТ БЕЛОК TAG7: ПЕРСПЕКТИВЫ ИСПОЛЬЗОВАНИЯ В МЕДИЦИНЕYashinD. V.ЯшинД. В.yashin_co@mail.ruSashchenkoL. P.СащенкоЛ. П.sashchenko@genebiology.ruGeorgievG. P.ГеоргиевГ. П.georgiev@genebiogy.ruInstitute of Gene Biology of RASИнститут биологии гена РАН0109202393982483220022025Copyright ©; 2023, Д.В. Яшин, Л.П. Сащенко, Г.П. ГеоргиевCopyright ©; 2023, Д.В. Яшин, Л.П. Сащенко, Г.П. Георгиев2023Д.В. Яшин, Л.П. Сащенко, Г.П. ГеоргиевД.В. Яшин, Л.П. Сащенко, Г.П. Георгиевhttps://journals.eco-vector.com/0869-5873/article/view/659547

Tag7 protein is a multifunctional protein with antitumor and anti-inflammatory effects. The interaction of Tag7 with the TREM-1 receptor on monocytes leads to the appearance of lymphocytes that kill tumor cells. The Tag7-Hsp70 complex binds to the TNFR1 receptor, causing cell death in a number of tumors through apoptosis and necroptosis. The Tag7-Mts1 complex interacts with the CCR5 receptor and attracts cytotoxic lymphocytes to the tumor. The interaction of Tag7 itself with TNFR1 and TREM-1 receptors prevents the binding of other ligands to this receptor, which gives an anti-inflammatory effect. Peptides imitating different Tag7 activities have been identified in Tag7. The results obtained allow us to count on possible applications of the Tag7 protein in the treatment of oncological and autoimmune diseases.

В статье рассматриваются свойства, а также возможности медицинского применения гена tag7 и белка Tag7, открытых в Институте биологии гена РАН. Tag7 – многофункциональный белок, обладающий противоопухолевым и противовоспалительным действием. Его взаимодействие с рецептором TREM-1 на моноцитах приводит к появлению лимфоцитов, убивающих опухолевые клетки. Tag7-Hsp70-комплекс связывается с рецептором TNFR1, вызывая гибель клеток ряда опухолей в процессе апоптоза и некроптоза. Комплекс Tag7-Mts1 взаимодействует с рецептором CCR5 и привлекает к опухоли цитотоксические лимфоциты. Взаимодействие самого Tag7 с рецепторами TNFR1 и TREM-1 препятствует связыванию других лигандов с этим рецептором, что инициирует противовоспалительный эффект. В составе Tag7 выявлены пептиды, имитирующие разные проявления его активности. Полученные результаты позволяют рассчитывать на возможное применение белка Tag7 в лечении онкологических и аутоиммунных заболеваний.

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