Vestnik of the Far East Branch of the Russian Academy of SciencesVestnik of the Far East Branch of the Russian Academy of SciencesВестник Дальневосточного отделения Российской академии наук0869-7698The Russian Academy of Sciences67604910.31857/S0869769824030034ISRZHAChemical Sciences. Bioorganic chemistryХимические науки. Биоорганическая химияReview ArticleBrown algae Costaria costata is a promising source of nutrients and biologically active compoundsБурая водоросль Costaria costata – перспективный источник питательных веществ и биологически активных соединенийImbsTatyana I.ИмбсТатьяна Игоревна
Russian Federation

Candidate of Sciences in Chemistry, Senior Researcher

кандидат химических наук, старший научный сотрудник

tatyanaimbs@mail.ruhttps://orcid.org/0000-0002-3262-0373MalyarenkoOlesya S.МаляренкоОлеся Сергеевна
Russian Federation

Candidate of Sciences in Chemistry, Senior Researcher

кандидат химических наук, старший научный сотрудник

malyarenko.os@gmail.comhttps://orcid.org/0000-0003-4039-5927BakuninaIrina Yu.БакунинаИрина Юрьевна
Russian Federation

Doctor of Sciences in Chemistry, Leading Researcher

доктор химических наук, ведущий научный сотрудник

bakun@list.ruhttps://orcid.org/0000-0003-4780-835XSchevchenkoNatalia M.ШевченкоНаталья Михайловна
Russian Federation

Candidate of Sciences in Chemistry, Senior Researcher

кандидат химических наук, старший научный сотрудник

natalyshe@piboc.dvo.ruhttps://orcid.org/0009-0002-6585-2506SurisValery V.СурицВалерий Викторович
Russian Federation

Junior Researcher

младший научный сотрудник

suritsw@yandex.ruhttps://orcid.org/0000-0002-5905-2046ErmakovaSvetlana P.ЕрмаковаСветлана Павловна
Russian Federation

Doctor of Sciences in Chemistry, Associate Professor, Head of the Laboratory

доктор химических наук, доцент, заведующая лабораторией

swsetlana_e@mail.ruG.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RASТихоокеанский институт биоорганической химии им. Г.Б. Елякова ДВО РАН150620243576828022025Copyright ©; 2024, Russian Academy of SciencesCopyright ©; 2024, Российская академия наук2024Russian Academy of SciencesРоссийская академия наукhttps://journals.eco-vector.com/0869-7698/article/view/676049

Brown algae are a rich source of essential nutrients, including carbohydrates, proteins, minerals, polyunsaturated lipids, as well as a number of other health-promoting compounds that can act on a wide range of diseases. An overview is presented of the chemical composition of the brown algae Costaria costata, the biological activity of the polysaccharide fucoidan and phlorotannin isolated from it – compounds characteristic only of brown algae, as well as the effects associated with their consumption.

Бурые водоросли являются богатым источником основных питательных веществ, включая углеводы, белки, минералы, полиненасыщенные липиды, а также ряд других полезных для здоровья соединений, способных воздействовать на широкий спектр заболеваний. Представлен обзор химического состава бурой водоросли Costaria costata, биологической активности выделенных из нее полисахарида фукоидана и флоротаннина – соединений, характерных только для бурых водорослей, а также эффектов, связанных с их потреблением.

Costaria costatabrown algafucoidanphlorotanninCostaria costataбурые водорослифукоиданыфлоротанниныCardoso S. M., Pereira O. R., Seca A. M.L., Pinto D. C.G.A., Silva A. M.S. Seaweeds as preventive agents for cardiovascular diseases: From nutrients to functional foods. Marine Drugs. 2015;13:6838–6865.Cardoso S. M., Pereira O. R., Seca A. M.L. et al. Seaweeds as preventive agents for cardiovascular diseases: From nutrients to functional foods // Mar. Drugs. 2015. Vol.13. P. 6838–6865.Belous O. S., Titlyanova T. V., Titlyanov E. Ya. Morskie rasteniya bukhty Troitsy i smezhnykh akvatorii (zaliv Petra Velikogo, Yaponskoe more) = [Marine plants of Troitsy Bay and adjacent water areas (Peter the Great Bay, Sea of Japan)]. Vladivostok: Dal’nauka; 2013. 264 p. (In Russ.).Белоус О. С., Титлянова Т. В., Титлянов Э. Я. Морские растения бухты Троицы и смежных акваторий (залив Петра Великого, Японское море). Владивосток: Дальнаука, 2013. 264 с.Denisova A. V., Krupnova T. N. Perspektivy kul’tivirovaniya kostarii rebristoi (Costaria costata) = [Prospects for cultivating Costaria costata]. Tezisy dokladov chetvertoi mezhdunarodnoi nauchno-prakticheskoi konferentsii «Morskie pribrezhnye ehkosistemy. Vodorosli, bespozvonochnye i produkty ikh pererabotki», Yuzhno-Sakhalinsk, 19–22 sentyabrya 2011 = [Abstracts of reports of the fourth international scientific and practical conference Marine coastal ecosystems. Algae, invertebrates and their products. Yuzhno-Sakhalinsk, 2011, 19–22 september]. Yuzhno-Sakhalinsk; 2011. P. 176–177. (In Russ.).Денисова А. В., Крупнова Т. Н. Перспективы культивирования костарии ребристой (Costaria costata) // Тезисы докладов четвертой международной научно-практической конференции «Морские прибрежные экосистемы. Водоросли, беспозвоночные и продукты их переработки», 19–22 сентября 2011 года, г. Южно-Сахалинск. Южно-Сахалинск: СахНИРО, 2011. С. 176–177.Sukhoveeva M. V., Podkorytova A. V. Promyslovye vodorosli i travy morei Dal’nego Vostoka: biologiya, raspredelenie, zapasy, tekhnologiya pererabotki = [Commercial algae and grasses of the seas of the Far East: biology, distribution, reserves, processing technology]. Vladivostok: TINRO-Tsentr; 2006. 244 p. (In Russ.).Суховеева М. В., Подкорытова А. В. Промысловые водоросли и травы морей Дальнего Востока: биология, распределение, запасы, технология переработки. Владивосток: ТИНРО-Центр, 2006. 244 с.Dawczynski C., Schubert R., Jahreis G. Amino acids, fatty acids, and dietary fiber in edible seaweed products. Food Chemistry. 2007;103:891–899.Dawczynski C., Schubert R., Jahreis G. Amino acids, fatty acids, and dietary fiber in edible seaweed products // Food Chem. 2007. Vol. 103. P. 891–899.Patarra R. F., Paiva L., Neto A. I. et al. Nutritional value of selected macroalgae. Journal of Applied Phycology. 2011;23:205–208.Patarra R. F., Paiva L., Neto A. I. et al. Nutritional value of selected macroalgae // J. Appl. Phycol. 2011. Vol. 23. P. 205–208.Imbs T. I., Shevchenko N. M., Sukhoverkhov S. V. et al. Seasonal variations of the composition and structural characteristics of polysaccharides from the brown alga Costaria costata. Chemistry of Natural Compounds. 2009;45(6):786–791.Имбс Т. И., Шевченко Н. М., Суховерхов С. В. и др. Сезонные изменения состава и структурные характеристики полисахаридов бурой водоросли Costaria costata // Химия природных соединений. 2009. № 6. С. 661–665.Deniaud-Bouët E., Kervarec N., Michel G. et al. Chemical and enzymatic fractionation of cell walls from Fucales: Insights into the structure of the extracellular matrix of brown algae. Annals of Botany. 2014;114:1203–1216.Deniaud-Bouët E., Kervarec N., Michel G. et al. Chemical and enzymatic fractionation of cell walls from Fucales: Insights into the structure of the extracellular matrix of brown algae // Ann. Bot. 2014. Vol. 114. P. 1203–1216.Usov A. I., Kosheleva E. A., Yakovlev A. P. Polysacharide composition of several brown algae of the Japan Sea. Bioorganicheskaya Khimiya. 1985;11(6):830–836. (In Russ.).Усов А. И., Кошелева Е. А., Яковлев А. П. Полисахаридный состав некоторых бурых водорослей Японского моря // Биоорг. химия. 1985. Т. 11, № 6. С. 830–836.Imbs T. I., Krasovskaya N. P., Ermakova S. P. et al. Comparative study of chemical composition and antitumor activity of aqueous-ethanol extracts of brown algae Laminaria cichorioides, Costaria costata, and Fucus evanescens. Russian Journal of Marine Biology. 2009;35(2):164–170.Имбс Т. И., Красовская Н. П., Ермакова С. П. и др. Сравнительное исследование химического состава и противоопухолевой активности водно-этанольных экстрактов бурых водорослей Laminaria cichorioides, Costaria costata и Fucus evanescens // Биология моря. 2009. Т. 35, № 2. С. 140–146.Imbs T. I. Polisakharidy i nizkomolekulyarnye metabolity nekotorykh massovykh vidov burykh vodoroslei morei Dal’nego Vostoka Rossii. Sposob kompleksnoi pererabotki vodoroslei: dis. kand. khim. nauk (dissertatsiya kandidata khimicheskikh nauk) = [Polysaccharides and low-molecular metabolites of some common species of brown algae in the seas of the Russian Far East. Method for complex processing of algae: dissertation of a Candidate of Chemical Sciences] / PIBOC. Vladivostok; 2010. 122 p. (In Russ.).Имбс Т. И. Полисахариды и низкомолекулярные метаболиты некоторых массовых видов бурых водорослей морей Дальнего Востока России. Способ комплексной переработки водорослей: дис. … канд. хим. наук / ТИБОХ. Владивосток, 2010. 122 с.Anastyuk S. D., Shevchenko N. M., Nazarenko E. L. et al. Structural analysis of a highly sulfated fucan from the brown alga Laminaria cichorioides by tandem MALDI and ESI mass spectrometry. Carbohydrate Research. 2010;345(15):2206–2212.Anastyuk S. D., Shevchenko N. M., Nazarenko E. L. et al. Structural analysis of a highly sulfated fucan from the brown alga Laminaria cichorioides by tandem MALDI and ESI mass spectrometry // Carbohydr. Res. 2010. Vol. 345, N15. P. 2206–2212.Bilan M. I., Grachev A. A., Shashkov,A.S., Kelly M. et al. Further studies on the composition and structure of a fucoidan preparation from the brown alga Saccharina latissima. Carbohydrate Research. 2010;345(14):2038–2047.Bilan M. I., Grachev A. A., Shashkov A. S., Kelly M. et al. Further studies on the composition and structure of a fucoidan preparation from the brown alga Saccharina latissima // Carbohydr. Res. 2010. Vol. 345, N14. P. 2038–2047.Cumashi A., Ushakova N. A., Preobrazhenslaya N. E., D’Incecco A. et al. A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds. Glycobiology. 2007;17:541–552.Cumashi A., Ushakova N. A., Preobrazhenslaya N. E., D’Incecco A. et al. A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds // Glycobiology. 2007. Vol. 17. P. 541–552.Anastyuk S. D., Imbs T. I., Shevchenko N. M. et al. ESIMS analysis of fucoidan preparations from Costaria costata, extracted from alga at different life-stages. Carbohydrate Polymers. 2012;90:993–1002.Anastyuk S. D., Imbs T. I., Shevchenko N. M. et al. ESIMS analysis of fucoidan preparations from Costaria costata, extracted from alga at different life-stages // Carbohydr. Polym. 2012. Vol. 90. P. 993–1002.Ermakova S. P., Sokolova R. V., Kim S.-M. et al. Fucoidan from brown seaweeds Sargassum hornery, Eclonia cava, Costaria costata structural characteristics and anticancer activity. Applied Biochemistry and Biotechnology. 2011;164:841–850.Ermakova S. P., Sokolova R. V., Kim S.-M. et al. Fucoidan from brown seaweeds Sargassum hornery, Eclonia cava, Costaria costata structural characteristics and anticancer activity // Appl. Biochem. Biotechnol. 2011. Vol. 164. P. 841–850.Moon H. J., Park K. S., Ku M. J. et al. Effect of Costaria costata fucoidan on expression of matrix metalloproteinase-1 promoter, mRNA, and protein. Journal of Natural Products. 2009;72:1731–1734.Moon H. J., Park K. S., Ku M. J. et al. Effect of Costaria costata fucoidan on expression of matrix metalloproteinase-1 promoter, mRNA, and protein // J. Nat. Prod. 2009. Vol.72. P. 1731–1734.Prokofjeva M. M., Imbs T. I., Shevchenko N. M. et al. Fucoidans as Potential Inhibitors of HIV-1. Marine Drugs. 2013;11(8):3000–3014.Prokofjeva M. M., Imbs T. I., Shevchenko N. M. et al. Fucoidans as potential inhibitors of HIV-1 // Mar. Drugs. 2013. Vol. 11, N8. P. 3000–3014.Makarenkova I. D., Leonova G. N., Maystrovkaya O. S. et al. Antiviral effect of brown algae-derived sulphated polysaccharides in case of experimental tick-borne encephalitis: tying structure and function. Рacific Medical Journal. 2012;1:44–46. (In Russ.).Макаренкова И. Д., Леонова Г. Н., Майстровская О. С. и др. Противовирусная активность сульфатированных полисахаридов из бурых водорослей при экспериментальном клещевом энцефалите: связь структуры и функции // Тихоокеан. мед. журн. 2012. Т. 1. С. 44–46.Martínez J. H.I., Castañeda H. G.T. Preparation and chromatographic analysis of phlorotannins. Journal of Chromatographic Science. 2013;51:825–838.Martínez J. H.I., Castañeda H. G.T. Preparation and chromatographic analysis of phlorotannins // J. Chromatogr. Sci. 2013. Vol. 51. P. 825–838.Ragan M. A., Glombitza K. W. Phlorotannins, brown algal polyphenols. Progress in Phycological Research. 1986;4:129–241.Ragan M. A., Glombitza K. W. Phlorotannins, brown algal polyphenols // Prog. Phycol. Res. 1986. Vol. 4. P. 129–241.Imbs T. I., Zvyagintseva T. N. Phlorotannins are polyphenolic metabolites of brown algae. Russian Journal of Marine Biology. 2018;44(4):217–227. (In Russ.).Имбс Т. И., Звягинцева Т. Н. Флоротаннины – полифенольные метаболиты бурых водорослей // Биология моря. 2018. Т. 44, № 4. С. 217– 227.Tierney M. S., Soler-Vila A., Rai D. K. et al. UPLC-MS profiling of low molecular weight phlorotannin polymers in Ascophyllum nodosum, Pelvetia canaliculata and Fucus spiralis. Metabolomics. 2014;10:524–535.Tierney M. S., Soler-Vila A., Rai D. K. et al. UPLC-MS profiling of low molecular weight phlorotannin polymers in Ascophyllum nodosum, Pelvetia canaliculata and Fucus spiralis // Metabolomics. 2014. Vol. 10. P. 524–535.Silchenko A. S., Imbs T. I., Zvyagintseva T. N. et al. Brown alga metabolites – inhibitors of marine organism fucoidan hydrolases. Chemistry of Natural Compounds. 2017;53:345–350.Сильченко А. С., Имбс Т. И., Звягинцева Т. Н. и др. Метаболиты бурых водорослей – ингибиторы фукоидан-гидролаз морских организмов // Химия природ. соединений 2017. № 2. С. 291–295.Ferreres F., Lopes G., Gil-Izquierdo A. et al. Phlorotannin еxtracts from Fucales сharacterized by HPLC-DAD-ESI–MSn: approaches to hyaluronidase inhibitory capacity and antioxidant properties. Marine Drugs. 2012;10:2766–2781.Ferreres F., Lopes G., Gil-Izquierdo A. et al. Phlorotannin еxtracts from Fucales сharacterized by HPLC-DAD-ESI–MSn: approaches to hyaluronidase inhibitory capacity and antioxidant properties // Mar. Drugs. 2012. Vol. 10. P. 2766–2781.Tierney M. S., Smyth T. J., Rai D. K. et al. Enrichment of polyphenol contents and antioxidant activities of Irish brown macroalgae using food-friendly techniques based on polarity and molecular size. Food Chemistry. 2013;139:753–761.Tierney M. S., Smyth T. J., Rai D. K. et al. Enrichment of polyphenol contents and antioxidant activities of Irish brown macroalgae using food-friendly techniques based on polarity and molecular size // Food Chem. 2013. Vol. 139. P. 753–761.Krentz A. J., Bailey C. J. Oral antidiabetic agents: current role in type 2 diabetes mellitus. Drugs. 2005;65:385–411.Krentz A. J., Bailey C. J. Oral antidiabetic agents: current role in type 2 diabetes mellitus // Drugs. 2005. Vol. 65. P. 385–411.Yoon N. Y., Lee S.-H., Yong-Li, Kim S.-K. Phlorotannins from Ishige okamurae and their acetyl and butyrylcholinesterase inhibitory effects. Journal of Functional Foods. 2009;1:331–335.Yoon N. Y., Lee S.-H., Yong-Li, Kim S.-K. Phlorotannins from Ishige okamurae and their acetyl and butyrylcholinesterase inhibitory effects // J. Funct. Foods. 2009. Vol. 1. P. 331–335.Shibata T., Fujimoto K., Nagayama K. et al. Inhibitory activity of brown algal phlorotannins against hyaluronidase. International Journal of Food Science and Technology. 2002;37:703–709.Shibata T., Fujimoto K., Nagayama K. et al. Inhibitory activity of brown algal phlorotannins against hyaluronidase // Int. J. Food Sci. Technol. 2002. Vol. 37. P. 703–709.Imbs T. I., Silchenko A. S., Fedoreev S. A., et al. Fucoidanase inhibitory activity of phlorotannins from brown algae. Algal Research. 2018;32:54–59.Imbs T. I., Silchenko A. S., Fedoreev S. A. et al. Fucoidanase inhibitory activity of phlorotannins from brown algae // Algal Res. 2018. Vol. 32. P. 54–59.Malyarenko O. S., Imbs T. I., Ermakova S. P. In vitro anticancer and radiosensitizing activities of phlorethols from the brown alga Costaria costata. Molecules. 2020;25:115–122. 3208.Malyarenko O. S., Imbs T. I., Ermakova S. P. In vitro anticancer and radiosensitizing activities of phlorethols from the brown alga Costaria costata // Molecules. 2020. Vol. 25. P. 115–122. 3208.Bakunina I., Imbs T., Likhatskaya G. et al. Effect of phlorotannins from brown algae Costaria costata on α-N-acetylgalactosaminidase produced by duodenal adenocarcinoma and melanoma cells. Marine Drugs. 2023;21(33):1–18.Bakunina I., Imbs T., Likhatskaya G. et al. Effect of phlorotannins from brown algae Costaria costata on α-N-acetylgalactosaminidase produced by duodenal adenocarcinoma and melanoma cells // Mar. Drugs. 2023. Vol. 21, N33. P. 1–18.Holdt S. L., Kraan S. Bioactive compounds in seaweed: Functional food applications and legislation. Journal of Applied Phycology. 2011;23:543–597.Holdt S. L., Kraan S. Bioactive compounds in seaweed: Functional food applications and legislation // J. Appl. Phycol. 2011. Vol. 23. P. 543–597.Ninomiya K. Science of umami taste: Adaptation to gastronomic culture. Flavour. 2015;4:13.Ninomiya K. Science of umami taste: Adaptation to gastronomic culture // Flavour. 2015. Vol. 4. P. 13.Khotimchenko S. V. Lipidy morskikh vodoroslei-makrofitov i trav. Struktura, raspredelenie, analiz = [Lipids from macrophyte seaweeds and herbs. Structure, distribution, analysis]. Vladivostok: Dal’nauka; 2003. 234 p. (In Russ.).Хотимченко С. В. Липиды морских водорослей-макрофитов и трав. Структура, распределение, анализ. Владивосток: Дальнаука, 2003. 234 с.Nelson M. M., Phleger C. F., Nichols P. D. Seasonal lipid composition in macroalgae of the northeastern Pacific Ocean. Botanica Marina. 2002;45:58–65.Nelson M. M., Phleger C. F., Nichols P. D. Seasonal lipid composition in macroalgae of the northeastern Pacific Ocean // Bot. Mar. 2002. Vol. 45. P. 58–65.Pereira H., Barreira L., Figueiredo F. et al. Polyunsaturated fatty acids of marine macroalgae: Potential for nutritional and pharmaceutical applications. Marine Drugs. 2012;10:1920–1935.Pereira H., Barreira L., Figueiredo F. et al. Polyunsaturated fatty acids of marine macroalgae: Potential for nutritional and pharmaceutical applications // Mar. Drugs. 2012. Vol. 10. P. 1920–1935.Simopoulos A. P. The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomedicine and Pharmacotherapy. 2002;56:365–379.Simopoulos A. P. The importance of the ratio of omega-6/omega-3 essential fatty acids // Biomed. Pharmacother. 2002. Vol. 56. P. 365–379.Simopoulos A. The importance of the omega-6 /omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Experimental Biology and Medicine. 2008;233:674–688.Simopoulos A. The importance of the omega-6 /omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases // Exp. Biol. Med. 2008. Vol. 233. P. 674–688.Gerasimenko N. I., Busarova N. G., Moiseenko O. P. Seasonal changes in the content of lipids, fatty acids, and pigments in brown alga Costaria costat. Russian Journal of Plant Physiology. 2010;57(2):217–223. (In Russ.).Герасименко Н. И., Бусарова Н. Г., Моисеенко О. П. Сезонные изменения в содержании липидов, жирных кислот и пигментов бурой водоросли Costaria costata // Физиол. pастений. 2010. Т. 57, № 2. C. 217–223.Adrogué H. J., Madias N. E. The impact of sodium and potassium on hypertension risk. Seminars in Nephrology. 2014;34:257–272.Adrogué H. J., Madias N. E. The impact of sodium and potassium on hypertension risk // Semin. Nephrol. 2014. Vol. 34. P. 257–272.Moro C. O., Basile G. Obesity and medicinal plants. Fitoterapia. 2000;71:S73–S82.Moro C. O., Basile G. Obesity and medicinal plants // Fitoterapia. 2000. Vol. 71. P. S73–S82.Küpper F. C., Feiters M. C., Olofsson B., et al. Commemorating two centuries of iodine research: An interdisciplinary overview of current research. Angewandte Chemie International Edition. 2011;50:11598–11620.Küpper F. C., Feiters M. C., Olofsson B. et al. Commemorating two centuries of iodine research: An interdisciplinary overview of current research // Angew. Chem. Int. Ed. 2011. Vol. 50. P. 11598–11620.