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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Vestnik of the Far East Branch of the Russian Academy of Sciences</journal-id><journal-title-group><journal-title xml:lang="en">Vestnik of the Far East Branch of the Russian Academy of Sciences</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник Дальневосточного отделения Российской академии наук</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0869-7698</issn><publisher><publisher-name xml:lang="en">The Russian Academy of Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">676081</article-id><article-id pub-id-type="doi">10.31857/S0869769824030076</article-id><article-id pub-id-type="edn">ISBYZW</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Chemical Sciences. Molecular pharmacology</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Химические науки. Молекулярная фармакология</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Laboratory of bioassays and mechanism of action of bioactive substances: recent advances in bioactive compound</article-title><trans-title-group xml:lang="ru"><trans-title>Лаборатория биоиспытаний и механизма действия биологически активных веществ: недавние достижения в исследованиях биологически активных соединений</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Chaykina</surname><given-names>Elena L.</given-names></name><name xml:lang="ru"><surname>Чайкина</surname><given-names>Елена Леонидовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Researcher</p></bio><bio xml:lang="ru"><p>научный сотрудник</p></bio><email>chaykin.dima@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5587-2610</contrib-id><name-alternatives><name xml:lang="en"><surname>Agafonova</surname><given-names>Irina G.</given-names></name><name xml:lang="ru"><surname>Агафонова</surname><given-names>Ирина Григорьевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Candidate of Sciences in Biology, Senior Researcher</p></bio><bio xml:lang="ru"><p>кандидат биологических наук, старший научный сотрудник</p></bio><email>agafonova@piboc.dvo.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7737-0980</contrib-id><name-alternatives><name xml:lang="en"><surname>Yurchenko</surname><given-names>Ekaterina А.</given-names></name><name xml:lang="ru"><surname>Юрченко</surname><given-names>Екатерина Александровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Candidate of Sciences in Biology, Senior Researcher</p></bio><bio xml:lang="ru"><p>кандидат биологических наук, старший научный сотрудник</p></bio><email>eyurch@piboc.dvo.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0093-5757</contrib-id><name-alternatives><name xml:lang="en"><surname>Chingizova</surname><given-names>Ekaterina А.</given-names></name><name xml:lang="ru"><surname>Чингизова</surname><given-names>Екатерина Александровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Candidate of Sciences in Biology, Senior Researcher</p></bio><bio xml:lang="ru"><p>кандидат биологических наук, старший научный сотрудник</p></bio><email>martyyas@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9961-8350</contrib-id><name-alternatives><name xml:lang="en"><surname>Kozlovskiy</surname><given-names>Sergey A.</given-names></name><name xml:lang="ru"><surname>Козловский</surname><given-names>Сергей Антонович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Junior Researcher</p></bio><bio xml:lang="ru"><p>младший научный сотрудник</p></bio><email>sergeimerx@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3558-0821</contrib-id><name-alternatives><name xml:lang="en"><surname>Pislyagin</surname><given-names>Evgeny A.</given-names></name><name xml:lang="ru"><surname>Пислягин</surname><given-names>Евгений Александрович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Candidate of Sciences in Biology, Senior Researcher</p></bio><bio xml:lang="ru"><p>кандидат биологических наук, старший научный сотрудник</p></bio><email>pislyagin@hotmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Burylova</surname><given-names>Anna L.</given-names></name><name xml:lang="ru"><surname>Бурылова</surname><given-names>Анна Леонидовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Student</p></bio><bio xml:lang="ru"><p>студентка</p></bio><email>anaburylova1@gmail.com</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4027-9064</contrib-id><name-alternatives><name xml:lang="en"><surname>Menchinskaya</surname><given-names>Ekaterina S.</given-names></name><name xml:lang="ru"><surname>Менчинская</surname><given-names>Екатерина Сергеевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Candidate of Sciences in Biology, Senior Researcher</p></bio><bio xml:lang="ru"><p>кандидат биологических наук, старший научный сотрудник</p></bio><email>ekaterinamenchinskaya@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1073-4994</contrib-id><name-alternatives><name xml:lang="en"><surname>Aminin</surname><given-names>Dmitry L.</given-names></name><name xml:lang="ru"><surname>Аминин</surname><given-names>Дмитрий Львович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Corresponding Member of RAS, Doctor of Sciences in Biology, Head of the Laboratory</p></bio><bio xml:lang="ru"><p>член-корреспондент РАН, доктор биологических наук, заведующий лабораторией</p></bio><email>daminin@piboc.dvo.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS</institution></aff><aff><institution xml:lang="ru">Тихоокеанский институт биоорганической химии им. Г.Б. Елякова ДВО РАН</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Far Eastern Federal University</institution></aff><aff><institution xml:lang="ru">Дальневосточный федеральный университет</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2024-06-15" publication-format="electronic"><day>15</day><month>06</month><year>2024</year></pub-date><issue>3</issue><issue-title xml:lang="ru"/><fpage>121</fpage><lpage>142</lpage><history><date date-type="received" iso-8601-date="2025-02-28"><day>28</day><month>02</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Russian Academy of Sciences</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, Российская академия наук</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Russian Academy of Sciences</copyright-holder><copyright-holder xml:lang="ru">Российская академия наук</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/0869-7698/article/view/676081">https://journals.eco-vector.com/0869-7698/article/view/676081</self-uri><abstract xml:lang="en"><p>The main scientific direction of the laboratory of bioassays and mechanism of action of biologically active compounds of the G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS is the study on the biological activity of natural and synthetic compounds. The review briefly examines the laboratory’s main achievements over the past five years.</p></abstract><trans-abstract xml:lang="ru"><p>Основное научное направление лаборатории биоиспытаний и механизма действия биологически активных веществ Тихоокеанского института биоорганической химии им. Г.Б. Елякова ДВО РАН – изучение биологической активности природных и синтетических соединений. В обзоре кратко рассматриваются основные достижения лаборатории за последние пять лет.</p></trans-abstract><kwd-group xml:lang="en"><kwd>biologically active natural and synthetic compounds</kwd><kwd>search for biological activity</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>биологически активные природные и синтетические соединения</kwd><kwd>поиск биологической активности</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Klykov A. G., Barsukova E. N., Chaikina E. L., Anisimov M. M. Prospects and results of selection of Fagopyrum esculentum Moench for increased flavonoid content. Vestnik of the FEB RAS. 2019;(3):5–16. (In Russ).</mixed-citation><mixed-citation xml:lang="ru">Клыков А. Г., Барсукова Е. Н., Чайкина Е. Л., Анисимов М. М. Перспективы и результаты селекции Fagopyrum esculentum Moench на повышение содержания флавоноидов // Вестн. ДВО РАН. 2019. № 3. С. 5–16.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">Barsukova E. N., Klykov A. G., Chaikina E. L. Using tissue culture to create new forms of Fagopyrum esculentum Moenc. Russian Agricultural Science. 2019;(5):3–6. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Барсукова Е. Н., Клыков А. Г., Чайкина Е. Л. Использование метода культуры ткани для создания новых форм Fagopyrum esculentum Moench // Рос.с.-х. наука. 2019. № 5. С. 3–6.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">Klykov A., Chaikina E., Anisimov M., Borovaya S., Barsukova E. Rutin content in buckwheat (Fagopyrum esculentum Moench, F. tataricum (L.) Gaertn. and F. cymosum Meissn.) growth in the Far East of Russia. Folia Biologica Geologica. 2020;61(1):61–68.</mixed-citation><mixed-citation xml:lang="ru">Klykov A., Chaikina E., Anisimov M., Borovaya S., Barsukova E. Rutin content in buckwheat (Fagopyrum esculentum Moench, F. tataricum (L.) Gaertn. and F. cymosum Meissn.) growth in the Far East of Russia // Folia Biologica et Geologica. 2020. Vol 61 (1). P. 61–68. https://doi.org/10.3986/fbg0068.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">Barsukova E. N., Klykov A. G., Fisenko P. V., Borovaya S. A., Chaikina E. L. Usage of the method of biotechnology in the selection of buckwheat plants in the Far East. Vestnik of the FEB RAS. 2020;(4):58–66. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Барсукова Е. Н., Клыков А. Г., Фисенко П. В., Боровая С. А., Чайкина Е. Л. Использование методов биотехнологии в селекции гречихи на Дальнем Востоке // Вестн. ДВО РАН. 2020. №. 4 (212). С. 58–66.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">Borovaya S., Klykov A., Barsukova E., Chaikina E. Study of the effect of selective media with high doses of zinc on regeneration ability and rutin accumulation in common buckwheatin. Plants. 2022;11(3):264. https://doi.org/10.3390/plants11030264.</mixed-citation><mixed-citation xml:lang="ru">Borovaya S., Klykov A., Barsukova E., Chaikina E. Study of the effect of selective media with high doses of zinc on regeneration ability and rutin accumulation in common buckwheatin // Plants. 2022. Vol. 11 (3). P. 264. https://doi.org/10.3390/plants11030264.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">Barsukova E. N., Klykov A. G., Chaikina E. L. Breeding evaluation of buckwheat (Fagopyrum esculentum Moench) varieties obtained using copper and zinc ions. Agricult. Sci. 2023;374(9):84–89. https://doi.org/10.32634/0869-8155-2023-374-9-84-89. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Барсукова Е. Н., Клыков А. Г., Чайкина Е. Л. Селекционная оценка сортообразцов гречихи посевной (Fagopyrum esculentum Moench), полученных с использованием ионов меди и цинка // Аграрная наука. 2023. Т. 374, № 9. С. 84–89. https://doi.org/10.32634/0869-8155-2023-374-9-84-89.</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">Agafonova I. G., Kotel’nikov V.N., Gel’tser B. I. Features of structural and functional changes in the thoracic aorta in experimental arterial hypertension. Bull. Exp. Biol. Med. 2022;174(9):289–293. DOI:10.47056/0365-9615-2022-174-9-289-293. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Агафонова И. Г., Котельников В. Н., Гельцер Б. И. Особенности структурно-функциональных изменений грудной аорты при экспериментальной артериальной гипертензии // Бюл. эксперим. биол. мед. 2022. Т. 174, № 9. С. 289–293. DOI: 10.47056/0365-9615-2022-174-9-289-293.</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">Agafonova I. G., Kotel’nikov V.N., Gel’tser B. I. Magnetic resonance imaging of the rat brain in assessing the neuroprotective effects of histochrome in experimental arterial hypertension. Bull. Exp. Biol. Med. 2021;172(9):277–282. DOI: 10.47056/0365-9615-2021-172-9-277-282. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Агафонова И. Г., Котельников В. Н., Гельцер Б. И. Магнитно-резонансная томография головного мозга крыс в оценке нейропротективных эффектов гистохрома при экспериментальной артериальной гипертензии // Бюл. эксперим. биол. мед. 2021. Т. 172, № 9. C. 277–282. DOI: 10.47056/0365-9615-2021-172-9-277-282.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">The use of histochrome as a neuroprotective agent that prevents diffusion changes in brain tissue at the early stage of development of arterial hypertension: Pat. N2021110258 RF / Agafonova I. G., Mishchenko N. P., Kotelnikov V. N., Geltser B. I.; application 04/12/2021; publ. 02/07/2022. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Применение гистохрома в качестве нейропротекторного средства, предотвращающего диффузионные изменения ткани головного мозга на ранней стадии развития артериальной гипертензии: пат. № 2021110258 РФ / Агафонова И. Г., Мищенко Н. П., Котельников В. Н., Гельцер Б. И.; заявл.12.04.2021; опубл. 07.02.2022.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">Agafonova I. G., Kotelnikov V. N., Geltser B. I., Kolosova N. G., Stonik V. A. Assessment of Combined Therapy of Histochrome and Nebivalol as Angioprotectors on the Background of Experimental Hypertension by Magnetic Resonance Angiography. Appl. Magn. Resonance. 2018;49(2):217–225. https://doi.org/10.1007/s00723-017-0960-3.</mixed-citation><mixed-citation xml:lang="ru">Agafonova I. G., Kotelnikov V. N., Geltser B. I., Kolosova N. G., Stonik V. A. Assessment of combined therapy of histochrome and nebivalol as angioprotectors on the background of experimental hypertension by magnetic resonance angiography // Appl. Magn. Resonance. 2018. Vol. 49 (2). P. 217–225. https://doi.org/10.1007/s00723-017-0960-3.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">Agafonova I. G., Kotelnikov V. N., Geltser B. I. Assessment of the morphofunctional status of the brain of Wistar rats against the background of arterial hypertension using diffusion-weighted tomography. Bull. Exp. Biol. Med. 2021;171(2):247–252. DOI: 10.47056/0365-9615-2021-171-2-247-252. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Агафонова И. Г., Котельников В. Н., Гельцер Б. И. Оценка морфофункционального статуса головного мозга крыс Вистар на фоне артериальной гипертензии методом диффузионно-взвешенной томографии // Бюл. эксперим. биол. мед. 2021. Т. 171, № 2. С. 247–252. DOI: 10.47056/0365-9615-2021-171-2-247-252.</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">Chingizova E. A., Menchinskaya E. S., Chingizov A. R., Pislyagin E. A., Girich E. V., Yurchenko A. N., et al. Marine Fungal Cerebroside Flavuside B Protects HaCaT Keratinocytes against Staphylococcus aureus Induced Damage. Mar. Drugs. 2021;19(10):553. https://doi.org/10.3390/md19100553.</mixed-citation><mixed-citation xml:lang="ru">Chingizova E. A., Menchinskaya E. S., Chingizov A. R., Pislyagin E. A., Girich E. V., Yurchenko A. N., Guzhova I. V., Mikhailov V. V., Aminin D. L., Yurchenko E. A. Marine fungal cerebroside flavuside b protects HaCaT keratinocytes against Staphylococcus aureus induced damage // Mar. Drugs. 2021. Vol. 19 (10). P. 553. https://doi.org/10.3390/md19100553.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">Zhuravleva O. I., Chingizova E. A., Oleinikova G. K., Starnovskaya S. S., Antonov A. S., Kirichuk N. N., Menshov A. S., Popov R. S., Kim N. Y., Berdyshev D. V., Chingizov A. R., Kuzmich A. S., Guzhova I. V., Yurchenko A. N., Yurchenko E. A. Anthraquinone Derivatives and Other Aromatic Compounds from Marine Fungus Asteromyces cruciatus KMM 4696 and Their Effects against Staphylococcus aureus. Mar. Drugs. 2023;21(8):431. https://doi.org/10.3390/md210804314.</mixed-citation><mixed-citation xml:lang="ru">Zhuravleva O. I., Chingizova E. A., Oleinikova G. K., Starnovskaya S. S., Antonov A. S., Kirichuk N. N., Menshov A. S., Popov R. S., Kim N. Y., Berdyshev D. V., Chingizov A. R., Kuzmich A. S., Guzhova I. V., Yurchenko A. N., Yurchenko E. A. Anthraquinone derivatives and other aromatic compounds from marine fungus Asteromyces cruciatus KMM 4696 and their effects against Staphylococcus aureus // Mar. Drugs. 2023. Vol. 21 (8). P. 431. https://doi.org/10.3390/md21080431.</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">Yurchenko A. N., Zhuravleva O. I., Khmel O. O., Oleynikova G. K., Antonov A. S., Kirichuk N. N. et al. New Cyclopiane Diterpenes and Polyketide Derivatives from Marine Sediment-Derived Fungus Penicillium antarcticum KMM 4670 and Their Biological Activities. Mar. Drugs. 2023;21(11):584. https://doi.org/10.3390/md21110584.</mixed-citation><mixed-citation xml:lang="ru">Yurchenko A. N., Zhuravleva O. I., Khmel O. O., Oleynikova G. K., Antonov A. S., Kirichuk N. N., Chausova V. E., Kalinovsky A. I., Berdyshev D. V., Kim N. Y., Popov R. S., Chingizova E. A., Chingizov A. R., Isaeva M. P., Yurchenko E. A. New cyclopiane diterpenes and polyketide derivatives from marine sediment-derived fungus Penicillium antarcticum KMM 4670 and their biological activities // Mar. Drugs. 2023. Vol. 21 (11). P. 584. https://doi.org/10.3390/md21110584.</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">Zhuravleva O. I., Oleinikova G. K., Antonov A. S., Kirichuk N. N., Pelageev D. N., Rasin A. B. et al. New Antibacterial Chloro-Containing Polyketides from the Alga-Derived Fungus Asteromyces cruciatus KMM 4696. J. Fungi. 2022;8(5):454. https://doi.org/10.3390/jof8050454.</mixed-citation><mixed-citation xml:lang="ru">Zhuravleva O. I., Oleinikova G. K., Antonov A. S., Kirichuk N. N., Pelageev D. N., Rasin A. B., Menshov A. S., Popov R. S., Kim N. Y., Chingizova E. A., Chingizov A. R., Volchkova O. O., von Amsberg G., Dyshlovoy S. A., Yurchenko E. A., Guzhova I. V., Yurchenko A. N. New antibacterial chloro-containing polyketides from the alga-derived fungus Asteromyces cruciatus KMM 4696 // J. Fungi. 2022. Vol. 8 (5). P. 454. https://doi.org/10.3390/jof8050454.</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">Girich E. V., Rasin A. B., Popov R. S., Yurchenko E. A., Chingizova E. A., Trinh P. T.H. et al. New Tripeptide Derivatives Asperripeptides A-C from Vietnamese Mangrove-Derived Fungus Aspergillus terreus LM.5.2. Mar. Drugs. 2022;20(1):77. https://doi.org/10.3390/md20010077.</mixed-citation><mixed-citation xml:lang="ru">Girich E. V., Rasin A. B., Popov R. S., Yurchenko E. A., Chingizova E. A., Trinh P. T.H., Ngoc N. T.D., Pivkin M. V., Zhuravleva O. I., Yurchenko A. N. New tripeptide derivatives asperripeptides A-C from vietnamese mangrove-derived fungus Aspergillus terreus LM.5.2 // Mar. Drugs. 2022. Vol. 20 (1). P. 77. https://doi.org/10.3390/md20010077.</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">Leshchenko E. V., Berdyshev D. V., Yurchenko E. A., Antonov A. S., Borkunov G. V., Kirichuk N. N. et al. Bioactive Polyketides from the Natural Complex of the Sea Urchin-Associated Fungi Penicillium sajarovii KMM 4718 and Aspergillus protuberus KMM 4747. Int. J. Mol. Sci. 2023;24(23):16568. https://doi.org/10.3390/ijms242316568.</mixed-citation><mixed-citation xml:lang="ru">Leshchenko E. V., Berdyshev D. V., Yurchenko E. A., Antonov A. S., Borkunov G. V., Kirichuk N. N., Chausova V. E., Kalinovskiy A. I., Popov R. S., Khudyakova Y. V., Chingizova E. A., Chingizov A. R., Isaeva M. P., Yurchenko A. N. Bioactive polyketides from the natural complex of the sea urchin-associated fungi Penicillium sajarovii KMM 4718 and Aspergillus protuberus KMM 4747 // Int. J. Mol. Sci. 2023. Vol. 24 (23). 16568. https://doi.org/10.3390/ijms242316568.</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">Trinh P. T., Yurchenko A. N., Khmel O. O. et al. Cytoprotective Polyketides from Sponge-Derived Fungus Lopadostoma pouzarii. Molecules. 2022;27(21):7650. https://doi.org/10.3390/molecules27217650.</mixed-citation><mixed-citation xml:lang="ru">Trinh P. T., Yurchenko A. N., Khmel O. O., Dieu T. V., Ngoc N. T., Girich E. V., Menshov A. S., Kim N. Y., Chingizova E. A., Van T. T., Lee J. S., Lee H.-S., Yurchenko E. A. Cytoprotective polyketides from sponge-derived fungus Lopadostoma pouzarii // Molecules. 2022. Vol. 27 (21). P. 7650. https://doi.org/10.3390/molecules27217650.</mixed-citation></citation-alternatives></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">Belousova E. B., Zhuravleva O. I., Yurchenko E. A. et al. New Anti-Hypoxic Metabolites from Co-Culture of Marine-Derived Fungi Aspergillus carneus KMM 4638 and Amphichorda sp. KMM 4639. Biomolecules. 2023;13(5):741. https://doi.org/10.3390/biom13050741.</mixed-citation><mixed-citation xml:lang="ru">Belousova E. B., Zhuravleva O. I., Yurchenko E. A., Oleynikova G. K., Antonov A. S., Kirichuk N. N., Chausova V. E., Khudyakova Y. V., Menshov A. S., Popov R. S., Menchinskaya E. S., Pislyagin E. A., Mikhailov V. V., Yurchenko A. N. New anti-hypoxic metabolites from co-culture of marine-derived fungi Aspergillus carneus KMM 4638 and Amphichorda sp. KMM 4639 // Biomolecules. 2023. Vol. 13 (5). P. 741. https://doi.org/10.3390/biom13050741.</mixed-citation></citation-alternatives></ref><ref id="B20"><label>20.</label><citation-alternatives><mixed-citation xml:lang="en">Kozhushnaya A. B., Kolesnikova S. A., Yurchenko E. A. et al. Rhabdastrellosides A and B: Two New Isomalabaricane Glycosides from the Marine Sponge Rhabdastrella globostellata, and Their Cytotoxic and Cytoprotective Effects. Mar. Drugs. 2023;21(11):554. https://doi.org/10.3390/md21110554.</mixed-citation><mixed-citation xml:lang="ru">Kozhushnaya A. B., Kolesnikova S. A., Yurchenko E. A., Lyakhova E. G., Menshov A. S., Kalinovsky A. I., Popov R. S., Dmitrenok P. S., Ivanchina N. V. Rhabdastrellosides A and B: two new isomalabaricane glycosides from the marine sponge Rhabdastrella globostellata, and their cytotoxic and cytoprotective effects // Mar. Drugs. 2023. Vol. 21 (11). P. 554. https://doi.org/10.3390/md21110554.</mixed-citation></citation-alternatives></ref><ref id="B21"><label>21.</label><citation-alternatives><mixed-citation xml:lang="en">Guzii A. G., Makarieva T. N., Fedorov S. N., Menshov A. S., Denisenko V. A., Popov R. S., Yurchenko E. A., Menchinskaya E. S. et al. Toporosides A and B, Cyclopentenyl-Containing ω-Glycosylated Fatty Acid Amides, and Toporosides C and D from the Northwestern Pacific Marine Sponge Stelodoryx toporoki. J. Nat. Prod. 2022;85(4):1186–1191. https://doi.org/10.1021/acs.jnatprod.2c00130.</mixed-citation><mixed-citation xml:lang="ru">Guzii A. G., Makarieva T. N., Fedorov S. N., Menshov A. S., Denisenko V. A., Popov R. S., Yurchenko E. A., Menchinskaya E. S., Grebnev B. B., Iarotsckaia V. V., Kim N. Y., Stonik V. A. Toporosides A and B, Cyclopentenyl-Containing ω-Glycosylated Fatty Acid Amides, and Toporosides C and D from the Northwestern Pacific Marine Sponge Stelodoryx toporoki // J. Nat. Prod. 2022. Vol. 85 (4). P. 1186–1191. https://doi.org/10.1021/acs.jnatprod.2c00130.</mixed-citation></citation-alternatives></ref><ref id="B22"><label>22.</label><citation-alternatives><mixed-citation xml:lang="en">Yurchenko E. A., Kolesnikova S. A., Lyakhova E. G., Menchinskaya E. S., Pislyagin E. A., Chingizova E. A., Aminin D. L. Lanostane Triterpenoid Metabolites from a Penares sp. Marine Sponge Protect Neuro-2a Cells against Paraquat Neurotoxicity. Molecules. 2020;25(22):5397. https://doi.org/10.3390/molecules25225397.</mixed-citation><mixed-citation xml:lang="ru">Yurchenko E. A., Kolesnikova S. A., Lyakhova E. G., Menchinskaya E. S., Pislyagin E. A., Chingizova E. A., Aminin D. L. Lanostane triterpenoid metabolites from a Penares sp. marine sponge protect Neuro-2a cells against paraquat neurotoxicity // Molecules. 2020. Vol. 25 (22). 5397 [1–44]. https://doi.org/10.3390/molecules25225397.</mixed-citation></citation-alternatives></ref><ref id="B23"><label>23.</label><citation-alternatives><mixed-citation xml:lang="en">Yurchenko E. A., Menchinskaya E. S., Pislyagin E. A., Chingizova E. A., Girich E. V., Yurchenko A. N. et al. Cytoprotective Activity of p-Terphenyl Polyketides and Flavuside B from Marine-Derived Fungi against Oxidative Stress in Neuro-2a Cells. Molecules. 2021;26(12):3618. https://doi.org/10.3390/molecules26123618.</mixed-citation><mixed-citation xml:lang="ru">Yurchenko E. A., Menchinskaya E. S., Pislyagin E. A., Chingizova E. A., Girich E. V., Yurchenko A. N., Aminin D. L., Mikhailov V. V. Cytoprotective activity of p-terphenyl polyketides and flavuside b from marine-derived fungi against oxidative stress in Neuro-2a Cells // Molecules. 2021. Vol. 26. 3618. https://doi.org/10.3390/molecules26123618.</mixed-citation></citation-alternatives></ref><ref id="B24"><label>24.</label><citation-alternatives><mixed-citation xml:lang="en">Yurchenko E. A., Khmel O. O., Nesterenko L. E., Aminin D. L. The Kelch/Nrf2 Antioxidant System as a Target for Some Marine Fungal Metabolites. Oxygen. 2023;3 (4):374–385. https://doi.org/10.3390/oxygen3040024.</mixed-citation><mixed-citation xml:lang="ru">Yurchenko E. A., Khmel O. O., Nesterenko L. E., Aminin D. L. The Kelch/Nrf2 antioxidant system as a target for some marine fungal metabolites // Oxygen. 2023. Vol. 3 (4). P. 374–385. https://doi.org/10.3390/oxygen3040024.</mixed-citation></citation-alternatives></ref><ref id="B25"><label>25.</label><citation-alternatives><mixed-citation xml:lang="en">Aminin D., Polonik S. 1,4-Naphthoquinones: Some Biological Properties and Application. Chem. Pharm. Bull. 2020;68(1):46–57. https://doi.org/10.1248/cpb.c19-00911.</mixed-citation><mixed-citation xml:lang="ru">Aminin D., Polonik S. 1,4-naphthoquinones: some biological properties and application // Chem. Pharm. Bull. 2020. Vol. 68 (1). P. 46–57. https://doi.org/10.1248/cpb.c19-00911.</mixed-citation></citation-alternatives></ref><ref id="B26"><label>26.</label><citation-alternatives><mixed-citation xml:lang="en">Sabutski Y. E., Menchinskaya E. S., Shevchenko L. S., Chingizova E. A., Chingizov A. R., Popov R. S. et al. Synthesis and Evaluation of Antimicrobial and Cytotoxic Activity of Oxathiine-Fused Quinone-Thioglucoside Conjugates of Substituted 1,4-Naphthoquinones. Molecules. 2020;25(16). 3577. https://doi.org/10.3390/molecules25163577.</mixed-citation><mixed-citation xml:lang="ru">Sabutski Y. E., Menchinskaya E. S., Shevchenko L. S., Chingizova E. A., Chingizov A. R., Popov R. P., Denisenko V. A., Mikhailov V. V., Aminin D. L., Polonik S. G. Synthesis and Evaluation of antimicrobial and cytotoxic activity of oxathiine-fused quinone-thioglucoside conjugates of substituted 1,4-naphthoquinones // Molecules. 2020. Vol 25 (16). 3577. https://doi.org/10.3390/molecules25163577.</mixed-citation></citation-alternatives></ref><ref id="B27"><label>27.</label><citation-alternatives><mixed-citation xml:lang="en">Polonik S., Likhatskaya G., Sabutski Y., Pelageev D., Denisenko V., Pislyagin E. et al. Synthesis, Cytotoxic Activity Evaluation and Quantitative Structure-Activity Analysis of Substituted 5,8-Dihydroxy-1,4-naphthoquinones and Their O- and S-Glycoside Derivatives Tested against Neuro-2a Cancer Cells. Mar. Drugs. 2020;18(12). 602. https://doi.org/10.3390/md18120602.</mixed-citation><mixed-citation xml:lang="ru">Polonik S., Likhatskaya G., Sabutski Y., Pelageev D., Denisenko V., Pislyagin E., Chingizova E., Menchinskaya E., Aminin D. Synthesis, cytotoxic activity evaluation and quantitative structure‐activity analysis of substituted 5,8‐dihydroxy‐1,4‐naphthoquinones and their o‐ and s‐glycoside derivatives tested against Neuro‐2a cancer cells // Mar. Drugs. 2020. Vol. 18 (12). 602. https://doi.org/10.3390/md18120602.</mixed-citation></citation-alternatives></ref><ref id="B28"><label>28.</label><citation-alternatives><mixed-citation xml:lang="en">Menchinskaya E., Chingizova E., Pislyagin E., Likhatskaya G., Sabutski Y., Pelageev D. et al. Neuroprotective effect of 1,4-naphthoquinones in an in vitro model of paraquat and 6-OHDA-induced neurotoxicity. Int. J. Mol. Sci. 2021;22(18). 9933. https://doi.org/10.3390/ijms22189933.</mixed-citation><mixed-citation xml:lang="ru">Menchinskaya E., Chingizova E., Pislyagin E., Likhatskaya G., Sabutski Y., Pelageev D., Polonik S., Aminin D. Neuroprotective effect of 1,4-naphthoquinones in an in vitro model of paraquat and 6-OHDA-induced neurotoxicity // Int. J. Mol. Sci. 2021. Vol. 22. 9933. https://doi.org/10.3390/ijms22189933.</mixed-citation></citation-alternatives></ref><ref id="B29"><label>29.</label><citation-alternatives><mixed-citation xml:lang="en">Agafonova I., Chingizova E., Chaikina E., Menchinskaya E., Kozlovskiy S., Likhatskaya G. et al. Protection Activity of 1,4-Naphthoquinones in Rotenone-Induced Models of Neurotoxicity. Mar. Drugs. 2024;22(2):62. https://doi.org/10.3390/md22020062.</mixed-citation><mixed-citation xml:lang="ru">Agafonova I., Chingizova E., Chaikina E., Menchinskaya E., Kozlovskiy S., Likhatskaya G., Sabutski Y., Polonik S., Aminin D., Pislyagin E. Protection activity of 1,4-naphthoquinones in rotenone-induced models of neurotoxicity // Mar. Drugs 2024. Vol. 22. P. 62. https://doi.org/10.3390/md22020062.</mixed-citation></citation-alternatives></ref><ref id="B30"><label>30.</label><citation-alternatives><mixed-citation xml:lang="en">Pislyagin E. A., Aminin D. L. Purinergic P2X receptors as new molecular targets for the search and creation of new drugs. In: Research of natural compounds at the Pacific Institute of Bioorganic Chemistry named after. G. B. Elyakov. New approaches and results. Vladivostok; 2016. P. 45–51. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Пислягин Е. А., Аминин Д. Л. Пуринергические P2X рецепторы как новые молекулярные мишени для поиска и создания новых лекарственных средств // Исследования природных соединений в Тихоокеанском институте биоорганической химии им. Г. Б. Елякова. Новые подходы и результаты. Владивосток, 2016. С. 45–51.</mixed-citation></citation-alternatives></ref><ref id="B31"><label>31.</label><citation-alternatives><mixed-citation xml:lang="en">Pislyagin E., Kozlovskiy S., Menchinskaya E., Chingizova E., Likhatskaya G., Gorpenchenko T. et al. Synthetic 1,4-Naphthoquinones inhibit P2X7 receptors in murine neuroblastoma cells. Bioorg. Med. Chem. 2021;31. 115975. https://doi.org/10.1016/j.bmc.2020.115975.</mixed-citation><mixed-citation xml:lang="ru">Pislyagin E., Kozlovskiy S., Menchinskaya E., Chingizova E., Likhatskaya G., Gorpenchenko T., Sabutski Y., Polonik S., Aminin D. Synthetic 1,4-naphthoquinones inhibit P2X7 receptors in murine neuroblastoma cells // Bioorg. Med. Chem. 2021. Vol. 31. 115975 [1–13]. https://doi.org/10.1016/j.bmc.2020.115975.</mixed-citation></citation-alternatives></ref><ref id="B32"><label>32.</label><citation-alternatives><mixed-citation xml:lang="en">Kozlovskiy S., Pislyagin E., Menchinskaya E., Chingizova E., Likhatskaya G., Sabutski Y., Polonik S., Aminin D. Anti-Inflammatory Activity of 1,4-Naphthoquinones Blocking P2X7 Purinergic Receptors in RAW 264.7 Macrophage Cells. Toxins. 2023;15(1):47. https:// doi.org/10.3390/toxins15010047.</mixed-citation><mixed-citation xml:lang="ru">Kozlovskiy S., Pislyagin E., Menchinskaya E., Chingizova E., Likhatskaya G., Sabutski Y., Polonik S., Aminin D. Anti-Inflammatory Activity of 1,4-Naphthoquinones Blocking P2X7 Purinergic Receptors in RAW 264.7 Macrophage Cells // Toxins. 2023. Vol. 15. P. 47. https:// doi.org/10.3390/toxins15010047.</mixed-citation></citation-alternatives></ref><ref id="B33"><label>33.</label><citation-alternatives><mixed-citation xml:lang="en">Kozlovskiy S., Pislyagin E., Menchinskaya E., Chingizova E., Kaluzhskiy L., Ivanov A. et al. Tetracyclic 1,4-naphthoquinone thioglucoside conjugate U-556 blocks the purinergic P2X7 receptor in macrophages and exhibits anti-inflammatory activity in vivo. Int. J. Mol. Sci. 2023;24(15). 12370. https://doi.org/10.3390/ijms241512370.</mixed-citation><mixed-citation xml:lang="ru">Kozlovskiy S., Pislyagin E., Menchinskaya E., Chingizova E., Kaluzhskiy L., Ivanov A. S., Likhatskaya G., Agafonova I., Sabutski Y., Polonik S., Manzhulo I., Aminin D. Tetracyclic 1,4-naphthoquinone thioglucoside conjugate U-556 blocks the purinergic P2X7 receptor in macrophages and exhibits anti-inflammatory activity in vivo // Int. J. Mol. Sci. 2023. Vol. 24. 12370. https://doi.org/10.3390/ijms241512370.</mixed-citation></citation-alternatives></ref><ref id="B34"><label>34.</label><citation-alternatives><mixed-citation xml:lang="en">Kozlovskiy S., Pislyagin E., Menchinskaya E., Chingizova E., Sabutski Y., Polonik S. et al. Antinociceptive effect and anti-inflammatory activity of 1,4-naphthoquinones in mice. Explor. Neurosci. 2024;3(1):39–50. https://doi.org/10.37349/en.2024.00035.</mixed-citation><mixed-citation xml:lang="ru">Kozlovskiy S., Pislyagin E., Menchinskaya E., Chingizova E., Sabutski Y., Polonik S., Agafonova I., Aminin D. Antinociceptive effect and anti-inflammatory activity of 1,4-naphthoquinones in mice // Explor. Neurosci. 2024. Vol. 3. P. 39–50. https://doi.org/10.37349/en.2024.00035.</mixed-citation></citation-alternatives></ref><ref id="B35"><label>35.</label><citation-alternatives><mixed-citation xml:lang="en">Menchinskaya E. S., Pislyagin E. A., Kovalchyk S. N., Davydova V. N., Silchenko A. S., Avilov S. A. et al. Antitumor activity of cucumarioside A2-2. Chemotherapy. 2013;59(3):181–191. https://doi.org/10.1159/000354156.</mixed-citation><mixed-citation xml:lang="ru">Menchinskaya E. S., Pislyagin E. A., Kovalchuk S. N., Davydova V. N., Silchenko A. S., Avilov S. A., Kalinin V. I., Aminin D. L. Antitumor activity of cucumarioside A2-2 // Chemotherapy. 2013. Vol. 59 (3). P. 181–191. https://doi.org/10.1159/000354156.</mixed-citation></citation-alternatives></ref><ref id="B36"><label>36.</label><citation-alternatives><mixed-citation xml:lang="en">Menchinskaya E. S., Aminin D. L., Avilov S. A., Silchenko A. S., Andryjashchenko P. V., Kalinin V. I. et al. Inhibition of tumor cells multidrug resistance by cucumarioside A2-2, frondoside A and their complexes with cholesterol. Nat. Prod. Comm. 2013;8(10):1377–1380. https://doi.org/10.1177/1934578X1300801009.</mixed-citation><mixed-citation xml:lang="ru">Menchinskaya E. S., Aminin D. L., Avilov S. A., Silchenko A. S., Andryjashchenko P. V., Kalinin V. I., Stonik V. A. Inhibition of tumor cells multidrug resistance by cucumarioside A2-2, frondoside A and their complexes with cholesterol // Nat. Prod. Comm. 2013. Vol. 8 (10). P. 1377–1380. https://doi.org/10.1177/1934578X1300801009.</mixed-citation></citation-alternatives></ref><ref id="B37"><label>37.</label><citation-alternatives><mixed-citation xml:lang="en">Menchinskaya E., Gorpenchenko T., Silchenko A., Avilov S., Aminin D. Modulation of doxorubicin intracellular accumulation and anticancer activity by triterpene glycoside cucumarioside A2-2. Mar. Drugs. 2019;17(11). 597. https://doi.org/10.3390/md17110597.</mixed-citation><mixed-citation xml:lang="ru">Menchinskaya E., Gorpenchenko T., Silchenko A., Avilov S., Aminin D. Modulation of doxorubicin intracellular accumulation and anticancer activity by triterpene glycoside cucumarioside A2-2 // Mar. Drugs. 2019. Vol. 17 (11). 597 [1–9]. https://doi.org/10.3390/md17110597</mixed-citation></citation-alternatives></ref><ref id="B38"><label>38.</label><citation-alternatives><mixed-citation xml:lang="en">Menchinskaya E. S., Dyshlovoy S. A., Venz S., Jacobsen C., Hauschild J., Rohlfing T. et al. Anticancer Activity of the Marine Triterpene Glycoside Cucumarioside A2-2 in Human Prostate Cancer Cells. Mar. Drugs. 2024;22(1):20.</mixed-citation><mixed-citation xml:lang="ru">Menchinskaya E. S., Dyshlovoy S. A., Venz S., Jacobsen C., Hauschild J., Rohlfing T., Silchenko A. S., Avilov S. A., Balabanov S., Bokemeyer C., Aminin D. L., von Amsberg G., Honecker F. Anticancer activity of the marine triterpene glycoside cucumarioside A2-2 in human prostate cancer cells // Mar. Drugs. 2024. Vol. 22 (1). 20 [1–16]. https://doi.org/10.3390/md22010020.</mixed-citation></citation-alternatives></ref><ref id="B39"><label>39.</label><citation-alternatives><mixed-citation xml:lang="en">Silchenko A. S., Kalinovsky A. I., Avilov S. A., Popov R. S., Dmitrenok P. S., Chingizova E. A. et al. Djakonoviosides A, A1, A2, B1–B4 — Triterpene Monosulfated Tetra- and Pentaosides from the Sea Cucumber Cucumaria djakonovi: The First Finding of a Hemiketal Fragment in the Aglycones; Activity against Human Breast Cancer Cell Lines. Int. J. Mol. Sci. 2023;24(13). 11128. https://doi.org/10.3390%2Fijms241311128.</mixed-citation><mixed-citation xml:lang="ru">Silchenko A. S., Kalinovsky A. I., Avilov S. A., Popov R. S., Dmitrenok P. S., Chingizova E. A., Menchinskaya E S., Panina E. G., Stepanov V. G., Kalinin V. I., Stonik V. A. Djakonoviosides A, A1, A2, B1–B4 – triterpene monosulfated tetra- and pentaosides from the sea cucumber Cucumaria djakonovi: The first finding of a hemiketal fragment in the aglycones; activity against human breast cancer cell lines // Int. J. Mol. Sci. 2023. Vol. 24 (13). 11128 [1–24]. https://doi.org/10.3390%2Fijms241311128.</mixed-citation></citation-alternatives></ref><ref id="B40"><label>40.</label><citation-alternatives><mixed-citation xml:lang="en">Silchenko A. S., Kalinovsky A. I., Avilov S. A., Popov R. S., Chingizova E. A., Menchinskaya E. S. et al. Sulfated Triterpene Glycosides from the Far Eastern Sea Cucumber Cucumaria djakonovi: Djakonoviosides C1, D1, E1, and F1; Cytotoxicity against Human Breast Cancer Cell Lines; Quantitative Structure-Activity Relationships. Mar. Drugs. 2023;21(12). 602. https://doi.org/10.3390/md21120602.</mixed-citation><mixed-citation xml:lang="ru">Silchenko A. S., Kalinovsky A. I., Avilov S. А., Popov R. S., Chingizova E. A., Menchinskaya E. S., Zelepuga E. A., Panina E. G., Stepanov V. G., Kalinin V. I., Dmitrenok P. S. Sulfated triterpene glycosides from the Far Eastern sea cucumber Cucumaria djakonovi: Djakonoviosides C1, D1, E1, and F1; cytotoxicity against human breast cancer cell lines; quantitative structure–activity relationships // Mar. Drugs. 2023. Vol. 21 (12). 602 [1–29]. https://doi.org/10.3390/md21120602.</mixed-citation></citation-alternatives></ref><ref id="B41"><label>41.</label><citation-alternatives><mixed-citation xml:lang="en">Aminin D. L. Immunomodulatory properties of sea cucumber triterpene glycosides Marine and Freshwater Toxins. 2016;1:381–401. https://doi.org/10.1007/978-94-007-6419-4_3.</mixed-citation><mixed-citation xml:lang="ru">Aminin D. L. Immunomodulatory properties of sea cucumber triterpene glycosides // Marine and Freshwater Toxins. 2016. Vol. 1. P. 381–401. https://doi.org/10.1007/978-94-007-6419-4_3.</mixed-citation></citation-alternatives></ref><ref id="B42"><label>42.</label><citation-alternatives><mixed-citation xml:lang="en">Aminin D., Pislyagin E., Astashev M., Es’kov A., Kozhemyako V., Avilov S. et al. Glycosides from edible sea cucumbers stimulate macrophages via purinergic receptors. Sci. Rep. 2016;6. 39683. https://doi.org/10.1038/srep39683.</mixed-citation><mixed-citation xml:lang="ru">Aminin D., Pislyagin E., Astashev M. et al. Glycosides from edible sea cucumbers stimulate macrophages via purinergic receptors // Sci. Rep. 2016. Vol. 6 (1). 39683. https://doi.org/10.1038/srep39683.</mixed-citation></citation-alternatives></ref><ref id="B43"><label>43.</label><citation-alternatives><mixed-citation xml:lang="en">Pislyagin E. A., Dmitrenok P. S., Gorpenchenko T. Y., Avilov S. A., Silchenko A. S., Aminin D. L. Determination of cucumarioside A₂-2 in mouse spleen by radiospectroscopy, MALDI-MS and MALDI-IMS. Eur. J. Pharm. Sci. 2013;49(4):461–467.</mixed-citation><mixed-citation xml:lang="ru">Pislyagin E. A., Dmitrenok P. S., Gorpenchenko T. Y., Avilov S. A., Silchenko A. S., Aminin D. L. Determination of cucumarioside A2-2 in mouse spleen by radiospectroscopy, MALDI-MS and MALDI-IMS // Eur. J. Pharm. Sci. 2013. Vol. 49 (4). P. 461–467. https://doi.org/10.1016/j.ejps.2013.05.017.</mixed-citation></citation-alternatives></ref><ref id="B44"><label>44.</label><citation-alternatives><mixed-citation xml:lang="en">Pislyagin E. A., Manzhulo I. V., Dmitrenok P. S., Aminin D. L. Cucumarioside A2-2 causes changes in the morphology and proliferative activity in mouse spleen. Acta Histochemica. 2016;118(4):387–392. http://dx.doi.org/10.1016/j.acthis.2016.03.009.</mixed-citation><mixed-citation xml:lang="ru">Pislyagin E. A., Manzhulo I. V., Dmitrenok P. S., Aminin D. L. Cucumarioside A2-2 causes changes in the morphology and proliferative activity in mouse spleen // Acta Histochemica. 2016. Vol. 118. P. 387–392. http://dx.doi.org/10.1016/j.acthis.2016.03.009.</mixed-citation></citation-alternatives></ref><ref id="B45"><label>45.</label><citation-alternatives><mixed-citation xml:lang="en">Pislyagin E. A., Manzhulo I. V., Gorpenchenko T. Y., Dmitrenok P. S., Avilov S. A., Silchenko A. S. et al. Cucumarioside A2-2 Causes Macrophage Activation in Mouse Spleen. Mar. Drugs. 2017;15(11). 341. https://doi.org/10.3390%2Fmd15110341.</mixed-citation><mixed-citation xml:lang="ru">Pislyagin E. A., Manzhulo I. V., Gorpenchenko T. Y., Dmitrenok P. S., Avilov S. A., Silchenko A. S., Wang Y-M., Aminin D. L. Cucumarioside A2-2 causes macrophage activation in mouse spleen // Mar. Drugs. 2017. Vol. 15 (11). 341. https://doi.org/10.3390%2Fmd15110341.</mixed-citation></citation-alternatives></ref><ref id="B46"><label>46.</label><citation-alternatives><mixed-citation xml:lang="en">Aminin D., Wang Y. M. Macrophages as a «weapon» in anticancer cellular immunotherapy. Kaohsiung J. Med. Sci. 2021;37(9):749–758. https://doi.org/10.1002/ kjm2.12405.</mixed-citation><mixed-citation xml:lang="ru">Aminin D., Wang Y.-M. Macrophages as a “weapon” in anticancer cellular immunotherapy // Kaohsiung J. Med. Sci. 2021. Vol. 37 (9). P. 749–758. https://doi.org/10.1002/ kjm2.12405.</mixed-citation></citation-alternatives></ref><ref id="B47"><label>47.</label><citation-alternatives><mixed-citation xml:lang="en">Chuang W. H., Pislyagin E., Lin L. Y., Menchinskaya E., Chernikov O., Kozhemyako V. et al. Holothurian triterpene glycoside cucumarioside A2-2 induces macrophages activation and polarization in cancer immunotherapy. Cancer Cell Int. 2023;23(1):292. https://doi.org/10.1186/s12935-023-03141-z.</mixed-citation><mixed-citation xml:lang="ru">Chuang W. H., Pislyagin E., Lin L.-Y., Menchinskaya E., Chernikov O., Kozhemyako V., Gorpenchenko T., Manzhulo I., Chaikina E., Agafonova I., Silchenko A., Avilov S., Stonik V., Tzou S.-C., Aminin D., Wang Y. M. Holothurian triterpene glycoside cucumarioside A2-2 induces macrophages activation and polarization in cancer immunotherapy // Cancer Cell Int. 2023. Vol. 23 (1). 292 [1–17]. https://doi.org/10.1186/s12935-023-03141-z.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
