Vestnik of the Far East Branch of the Russian Academy of SciencesVestnik of the Far East Branch of the Russian Academy of SciencesВестник Дальневосточного отделения Российской академии наук0869-7698The Russian Academy of Sciences68889110.31857/S0869769825010079HHLICWChemical SciencesХимические наукиResearch ArticleMarine invertebrate lectins: isolation, properties and biological activityЛектины морских беспозвоночных: выделение, свойства и биологическая активностьhttps://orcid.org/0000-0001-5102-9311ChikalovetsIrina V.ЧикаловецИрина Владимировна
Russian Federation

Candidate of Sciences in Chemistry, Senior Researcher

кандидат химических наук, старший научный сотрудник

ivchik6@mail.ruhttps://orcid.org/0000-0002-9587-897XMizginaTatyana O.МизгинаТатьяна Олеговна
Russian Federation

Candidate of Sciences in Chemistry, Junior Researcher

кандидат химических наук, младший научный сотрудник

tanya.tasha@mail.ruhttps://orcid.org/0009-0000-6293-6582FilshteinAlina P.ФильштейнАлина Петровна
Russian Federation

Candidate of Sciences in Chemistry, Junior Researcher

кандидат химических наук, младший научный сотрудник

alishichka@mail.ruhttps://orcid.org/0000-0001-5358-5880KuzmichAlexandra S.КузьмичАлександра Сергеевна
Russian Federation

Researcher

научный сотрудник

assavina@mail.ruhttps://orcid.org/0000-0002-3076-3637ChernikovOleg V.ЧерниковОлег Викторович
Russian Federation

Candidate of Sciences in Biology, Deputy Director

кандидат биологических наук, заместитель директора

chernikov@piboc.dvo.ruElyakov Pacific Institute of Bioorganic Chemistry of FEB RASТихоокеанский институт биоорганической химии им. Г.Б. Елякова ДВО РАН0407202511041190908202509082025Copyright ©; 2025, Russian Academy of SciencesCopyright ©; 2025, Российская академия наук2025Russian Academy of SciencesРоссийская академия наукhttps://journals.eco-vector.com/0869-7698/article/view/688891

Interest in marine organisms is due to the high content of biologically active substances in them, which are objects of fundamental and applied biomedical research and are effective in the development of therapeutic and prophylactic agents against a wide range of diseases. The laboratory of chemistry of non-infectious immunity of PIBOC FEB RAS conducts research on the screening, isolation, structure determination, study of physicochemical properties and biological activity of lectins from marine invertebrates. Lectins of different carbohydrate specificity have been isolated from bivalve mollusks, the physiological role of which is to participate in the innate immunity of mollusks. These proteins have different biological activity, including antibacterial and antiproliferative.

Интерес к морским организмам обусловлен большим содержанием в них биологически активных веществ, которые являются объектами фундаментальных и прикладных медико-биологических исследований и эффективны для разработки терапевтических и профилактических средств против широкого спектра заболеваний. В лаборатории химии неинфекционного иммунитета ТИБОХ ДВО РАН проводят исследования по поиску, выделению, установлению структуры, изучению физико-химических свойств и биологической активности лектинов из морских беспозвоночных. Из двустворчатых моллюсков были выделены лектины разной углеводной специфичности, физиологическая роль которых заключается в участии во врожденном иммунитете моллюсков. Эти белки обладают разной биологической активностью, в том числе антибактериальной и антипролиферативной.

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