Toxicological ReviewToxicological ReviewТоксикологический вестник0869-7922Federal Scientific Center of Hygiene named after F.F. Erisman64102210.36946/0869-7922-2017-4-40-49ArticlesСтатьиTHE PROBLEM OF THE INTERMEDIATE SYNDROME FOLLOWING POISONING WITH ANTI-CHOLINESTERASE AGENTSПРОБЛЕМА ПРОМЕЖУТОЧНОГО СИНДРОМА ПРИ ОТРАВЛЕНИЯХ АНТИХОЛИНЭСТЕРАЗНЫМИ СОЕДИНЕНИЯМИTyuninM. A.ТюнинМ. А.
Russian Federation
ChepurS. V.ЧепурС. В.
Russian Federation
GogolevskyA. S.ГоголевскийА. С.
Russian Federation
SelivanovD. V.СеливановД. В.
Russian Federation
BurtsevaN. I.БурцеваН. И.
Russian Federation
IlyinskiyN. S.ИльинскийН. С.
Russian Federation
State Research and Test Institute of Military Medicine , S.M. Kirov Medical Military AcademyФГБУ «Государственный научноисследовательский испытательный институт военной медицины» Министерства обороны Российской Федерации280820174404904112024Copyright ©; 2017, Tyunin M.A., Chepur S.V., Gogolevsky A.S., Selivanov D.V., Burtseva N.I., Ilyinskiy N.S.Copyright ©; 2017, Тюнин М.А., Чепур С.В., Гоголевский А.С., Селиванов Д.В., Бурцева Н.И., Ильинский Н.С.2017Tyunin M.A., Chepur S.V., Gogolevsky A.S., Selivanov D.V., Burtseva N.I., Ilyinskiy N.S.Тюнин М.А., Чепур С.В., Гоголевский А.С., Селиванов Д.В., Бурцева Н.И., Ильинский Н.С.https://journals.eco-vector.com/0869-7922/article/view/641022

Etiology and pathogenesis current concepts of the intermediate syndrome in cases of poisoning with anticholinesterase compounds (organophosphorus compounds, carbamates) are considered in the review. Characteristics of the syndrome clinical picture and its diagnostics methods using electromyography are presented.. Data on the experience of broadly used basic antidotal agents (cholinesterase reactivators, M – and N-cholinoreceptors) and pathogenic therapy of poisonings were analyzed and summarized. To solve the problem, priority research directions were determined, such as search for formation mechanisms of the nondepolarizing neuromuscular blocker and development of methods for prophylaxis and therapy using drugs targeting N-cholinoreceptors.

В обзоре рассмотрены современные представления об этиологии и патогенезе промежуточного синдрома при отравлениях антихолинэстеразными соединениями (фосфорорганические соединения, карбаматы). Представлена характеристика клинической картины синдрома и методов его диагностики с использованием электромиографии. Проанализированы и обобщены данные об опыте применения широко используемых базисных средств антидотной (реактиваторы холинэстеразы, M- и N-холинолитики) и патогенетической терапии отравлений. Для решения проблемы в качестве приоритетных направлений исследований определены поиск механизмов формирования недеполяризационного нервно-мышечного блока и разработка способов профилактики и лечения с использованием препаратов, воздействующих на N-холинорецепторы.

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