Toxicological ReviewToxicological ReviewТоксикологический вестник0869-7922Federal Scientific Center of Hygiene named after F.F. Erisman64121710.36946/0869-7922-2020-1-45-48ArticlesСтатьиRESEARCH AND EVALUATION OF THE TOXICITY PARAMETERS OF NANO-DISPERSED MAGNESIUM OXIDE IN REPEATED INHALATION EXPOSUREИССЛЕДОВАНИЕ И ОЦЕНКА ПАРАМЕТРОВ ТОКСИЧНОСТИ НАНОДИСПЕРСНОГО ОКСИДА МАГНИЯ ПРИ МНОГОКРАТНОМ ИНГАЛЯЦИОННОМ ВОЗДЕЙСТВИИStepankovM. S.СтепанковМ. С.
Russian Federation

614045, Perm

Степанков Марк Сергеевич, лаборант-исследователь лаборатории биохимической и наносенсорной диагностики

614045, г. Пермь

mmm2920@mail.ruFederal Scientific Center for Medical and Preventive Health Risk Management TechnologiesФБУН ФНЦ медико-профилактических технологий управления рисками здоровью населения240220201454804112024Copyright ©; 2020, Stepankov M.S.Copyright ©; 2020, Степанков М.С.2020Stepankov M.S.Степанков М.С.https://journals.eco-vector.com/0869-7922/article/view/641217

A repeated inhalation exposure of Wistar rats to an aerosol of aqueous suspension of nano-dispersed magnesium oxide (5-100 nm) with actual concentration of 0,485 ± 0,121 mg/m3 has been studied. There was a significant increase in the activity of alanine aminotransferase, as well as the number of leukocytes and platelets, thrombocrit. At the same time, a significant decrease in stab neutrophils and monocytes has been noted. In animals of the experimental group, acute plethora has been found in the tissues of the brain, heart, lungs, liver, pancreas, and kidneys. Subarachnoid hemorrhages in the brain; hemorrhagic heart attacks and hyperplasia of lung tissue; hyperplasia of the myeloid germ of hematopoietic bone marrow and lymphoid tissue of the small intestine; eosinophilia of infiltrate in the stomach and large intestine have been established. The results obtained make it possible to increase the effectiveness of substantiating preventive measures for workers and population exposed to inhalation exposure to nanoparticles of magnesium oxide.

П роведена многократная ингаляционная экспозиция крыс линии Wistar аэрозолем водной суспензии нанодисперсного оксида магния (5-100 нм) в фактической концентрации 0,485±0,121 мг/м3. Установлено достоверное увеличение активности аланинаминотрансферазы, количества лейкоцитов и тромбоцитов, тромбокрита. Отмечено достоверное снижение палочкоядерных нейтрофилов и моноцитов. У животных опытной группы установлено острое полнокровие в тканях головного мозга, сердца, лёгких, печени, поджелудочной железы и почках. Установлены субарахноидальные кровоизлияния в головном мозге; геморрагические инфаркты и гиперплазия ткани лёгких; гиперплазия миелоидного ростка кроветворения костного мозга и лимфоидной ткани тонкого кишечника; эозинофилия инфильтрата в желудке и толстом кишечнике. Полученные результаты позволяют повысить эффективность обоснования мер профилактики для работающих и населения, подвергающихся ингаляционной экспозиции наноразмерных частиц оксида магния.

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