Toxicological ReviewToxicological ReviewТоксикологический вестник0869-7922Federal Scientific Center of Hygiene named after F.F. Erisman64132210.15690/vramn457ArticlesСтатьиTHE CHANGE OF HUMORAL AND CELLULAR IMMUNE RESPONSES, OF TH1-, TH2- LYMPHOCYTES FUNCTIONS AND CYTOKINE CONCENTRATIONS IN BLOOD AFTER CHRONIC INTOXICATION WITH TRICHLOROETHYLENEИЗМЕНЕНИЕ ГУМОРАЛЬНЫХ И КЛЕТОЧНЫХ ИММУННЫХ РЕАКЦИЙ, ФУНКЦИИ TH1-, TH2-ЛИМФОЦИТОВ И КОНЦЕНТРАЦИИ ЦИТОКИНОВ В КРОВИ ПОСЛЕ ХРОНИЧЕСКОЙ ИНТОКСИКАЦИИ ТРИХЛОРЭТИЛЕНОМZabrodskiiP. F.ЗабродскийП. Ф.
Russian Federation
MaslyakovV. V.МасляковВ. В.
Russian Federation
GromovM. S.ГромовМ. С.
Russian Federation
120620153404304112024Copyright ©; 2015, Zabrodskii P.F., Maslyakov V.V., Gromov M.S.Copyright ©; 2015, Забродский П.Ф., Масляков В.В., Громов М.С.2015Zabrodskii P.F., Maslyakov V.V., Gromov M.S.Забродский П.Ф., Масляков В.В., Громов М.С.https://journals.eco-vector.com/0869-7922/article/view/641322

It was established in experiments on non-inbred albino rats that chronic intoxication with trichlorethylene (30 days, subcutaneously daily 0.05 LD50) ) largely decreased Th2- cells activity as compared to Th1-lyphocytes and as well as humoral immune responses as compared to the cellular immune response. Trichloroethylene decreased levels of immune regulatory cytokines IFN-γ, IL-2, IL-4 in blood ,increased the concentration of pro-inflammatory cytokine IL-6, and insignificantly raised levels of anti-inflammatory cytokines IL-10, IL-13 in blood.

В экспериментах на аутбредных белых крысах установлено, что хроническая интоксикация трихлорэтиленом (30 сут, ежедневно подкожно 0,05 DL50), в большей степени снижала активность Th2-клеток по сравнению с Th1-лимфоцитами, а также гуморальные иммунные реакции по сравнению с клеточным иммунным ответом. Трихлорэтилен уменьшал содержание в крови иммунорегуляторных цитокинов ИФН- , ИЛ-2, ИЛ-4 и увеличивал концентрацию провоспалительного цитокина ИЛ-6, незначительно повышал содержание в крови антивоспалительных цитокинов ИЛ-10, ИЛ-13.

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