Toxicological ReviewToxicological ReviewТоксикологический вестник0869-7922Federal Scientific Center of Hygiene named after F.F. Erisman64147610.47470/0869-7922-2023-31-2-83-88Original articlesОригинальные статьиAssociation of glutathione-S-transferase gene polymorphisms with various disease (review of foreign studies)Взаимосвязь полиморфизмов генов семейства глутатион-S-трансфераз с различными заболеваниями (обзор зарубежной литературы)https://orcid.org/0000-0002-4109-9268BerezaIvan AndreevichБерёзаИван Андреевич
Russian Federation

Researcher, Department of Molecular Biology and Electron Microscopy, FBRI YMRC PHPIW of Rospotrebnadzor, 620014, Yekaterinburg, Russian Federation.

e-mail: ivan11011994@gmail.com

Научный сотрудник отдела молекулярной биологии и электронной микроскопии ФБУН «Екатеринбургский медицинский-научный центр профилактики и охраны здоровья рабочих промпредприятий» Роспотребнадзора, 620014, г. Екатеринбург.

e-mail: ivan11011994@gmail.com

berezaia@ymrc.ruhttps://orcid.org/0000-0002-7029-3406ShaikhovaDaria RamilevnaШаиховаДарья Рамильевна
Russian Federation
darya.boo@mail.ruhttps://orcid.org/0000-0001-8794-7288AmrominaAnna MikhailovnaАмроминаАнна Михайловна
Russian Federation
amrominaam@ymrc.ruYekaterinburg Medical and Scientific Center for Prevention and Health Protection of Industrial Workers of the Federal Service for Supervision of Consumer Rights Protection and Human Well-BeingФБУН «Екатеринбургский медицинский-научный центр профилактики и охраны здоровья рабочих промпредприятий» Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека27042023312838804112024Copyright ©; 2023, Bereza I.A., Shaikhova D.R., Amromina A.M.Copyright ©; 2023, Берёза И.А., Шаихова Д.Р., Амромина А.М.2023Bereza I.A., Shaikhova D.R., Amromina A.M.Берёза И.А., Шаихова Д.Р., Амромина А.М.https://journals.eco-vector.com/0869-7922/article/view/641476

Introduction. This review is devoted to the association of GSTM1, GSTT1, GSTP1 gene polymorphisms with various diseases in foreign literature sources.

Material and methods. For this article, we used data published in foreign literature over the past 11 years. medline was extensively searched for eligible studies using the Pubmed search engine, and 30 studies were eventually selected for inclusion in this review.

Results. This review showed that researchers all over the world have repeatedly tried to evaluate the relationship between GST polymorphisms and various diseases, but in some cases received conflicting results. At the same time, many studies have found an association of pathologies with both single GST gene polymorphisms and combined polymorphic variants, which indicates a complex effect of antioxidant system genes.

Limitation of the study. The limitation of this review is the lack of domestic literary sources.

Conclusion. Further research of functional polymorphisms of the GST family genes are needed to develop effective systems for the diagnosis, prevention, and treatment of diseases.

Compliance with ethical standards. This study does not require the conclusion of a biomedical ethics committee or other documents.

Contribution. All co-authors made an equal contribution to the research and preparation of the article for publication.

Conflict of interests. The authors declare no conflict of interest.

Funding. The study had no sponsorship.

Received: January 1, 2023 / Accepted: February 2, 2023 / Published: April 30, 2023

Введение. Данный литературный обзор посвящён взаимосвязи полиморфизмов генов GSTM1, GSTT1, GSTP1 с различными заболеваниями, описанной в зарубежных источниках литературы.

Материалы и методы. Авторы использовали данные, опубликованные в зарубежной литературе за последние 11 лет. В базе данных Medline был проведён всесторонний поиск подходящих исследований с помощью поисковой системы Pubmed, и в итоге для включения в этот обзор были отобраны 30 исследований.

Результаты. Этот обзор показал, что исследователи во всем мире неоднократно пытались оценить связь между полиморфизмами GST и различными заболеваниями, но в ряде случаев получали противоречивые результаты. В то же время во многих исследованиях была обнаружена ассоциация патологий как с отдельным полиморфизмом генов GST, так и с комбинированными полиморфными вариантами, что свидетельствует о комплексном действии генов антиоксидантной системы.

Несмотря на часто противоречивые данные разных исследователей, не вызывает сомнения, что полиморфизмы GSTM1, GSTT1 и GSTP1 имеют достоверную взаимосвязь со многими нарушениями, в результате снижения эффективности антиоксидантной системы и ее способности к детоксикации ксенобиотиков.

Ограничение исследования. Ограничением данного обзора является отсутствие отечественных источников литературы.

Заключение. Необходимы дальнейшие исследования влияния функциональных полиморфизмов генов семейства для разработки эффективных систем тестирования, профилактики и лечения заболеваний.

Соблюдение этических стандартов. Исследование не требует представления заключения комитета по биомедицинской этик.

Участие авторов. Все соавторы внесли равнозначный вклад в исследование и подготовку статьи к публикации.

Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов

Финансирование. Исследование не имело спонсорской поддержки.

Поступила в редакцию: 20 января 2023 / Принята в печать: 02 февраля 2023 / Опубликована: 30 апреля 2023 

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