Russian Journal of PhysiologyRussian Journal of PhysiologyРоссийский физиологический журнал им. И.М. Сеченова0869-81392658-655XThe Russian Academy of Sciences65154910.31857/S0869813923070063XMINUFEXPERIMENTAL ARTICLESЭКСПЕРИМЕНТАЛЬНЫЕ СТАТЬИReactive Changes of Rat Spinal Cord Microgliocytes after Acute Systemic InflammationРеактивные изменения микроглиоцитов спинного мозга крысы при остром системном воспаленииKolosE. A.КолосЕ. А.koloselena1984@yandex.ruKorzhevskiiD. E.КоржевскийД. Э.koloselena1984@yandex.ruInstitute of Experimental MedicineИнститут экспериментальной медицины01072023109793394501022025Copyright ©; 2023, Е.А. Колос, Д.Э. КоржевскийCopyright ©; 2023, Е.А. Колос, Д.Э. Коржевский2023Е.А. Колос, Д.Э. КоржевскийЕ.А. Колос, Д.Э. Коржевскийhttps://journals.eco-vector.com/0869-8139/article/view/651549

It is widely known that neuroinflammation is a key factor in the development of many neurological pathologies and neurodegenerative diseases. The dynamics of development and duration of neuroinflammatory responses are critical aspects in understanding the patterns of physiological, biochemical and behavioral consequences. The most common object of study is neuroinflammation that develops after experimental systemic inflammation. The effect of acute systemic inflammation on brain microgliocytes has been studied extensively, while spinal cord microglia have been studied less frequently. The purpose of this study was to assess the topographic and temporal features of morphofunctional changes in rat spinal cord microglial cells after experimental LPS-induced systemic inflammation. It has been established that in the early stages of neuroinflammation (24 hours after LPS administration), microgliocytes are activated in the ventral white and ventral gray matter of the spinal cord. At the same time, microgliocytes of the dorsal part of the spinal cord do not show morphological attribute of activation. An increase in the population density of microgliocytes in the ventral funiculus of the spinal cord was noted. Accumulations (aggregates) of reactive microgliocytes were also found in this area.

В настоящее время широко известно, что ключевым фактором в развитии многих неврологических патологий и нейродегенеративных заболеваний является нейровоспаление. Динамика развития и продолжительность нейровоспалительных реакций являются критическими аспектами в понимании закономерностей формирования физиологических, биохимических и поведенческих последствий различных неврологических нарушений. Во многих работах процесс развития нейровоспаления, а также глиальная реакция изучаются при экспериментальном системном воспалении. Детально исследуется влияние острого системного воспаления на состояние микроглиоцитов головного мозга, в то время как микроглия спинного мозга изучается в меньшей степени. Цель настоящего исследования состояла в оценке топографических и временных особенностей морфофункциональных изменений клеток микроглии спинного мозга крыс при экспериментальном ЛПС-индуцированном системном воспалении. Установлено, что на ранних этапах нейровоспаления (через 24 ч после введения ЛПС) происходит активация микроглиоцитов в вентральном белом и вентральном сером веществе спинного мозга. При этом микроглиоциты дорсальной части спинного мозга не проявляют морфологических признаков активации. Отмечено увеличение плотности популяции микроглиоцитов в вентральном канатике спинного мозга, где также выявлены скопления (агрегаты) реактивных микроглиоцитов.

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