Russian Journal of PhysiologyRussian Journal of PhysiologyРоссийский физиологический журнал им. И.М. Сеченова0869-81392658-655XThe Russian Academy of Sciences65156310.31857/S0869813923050102XRPHSMEXPERIMENTAL ARTICLESЭКСПЕРИМЕНТАЛЬНЫЕ СТАТЬИVascular Effects of Perinatal Hypoxia in the Early Postnatal Period in RatsСосудистые эффекты перинатальной гипоксии в раннем постнатальном периоде у крысShvetsovaA. A.ШвецоваА. А.Dina.Gaynullina@gmail.comKhukharevaD. D.ХухареваД. Д.Dina.Gaynullina@gmail.comSimonenkoS. D.СимоненкоС. Д.Dina.Gaynullina@gmail.comKhlystovaM. A.ХлыстоваМ. А.Dina.Gaynullina@gmail.comBorzykhA. A.БорзыхА. А.Dina.Gaynullina@gmail.comGaynullinaD. K.ГайнуллинаД. К.Dina.Gaynullina@gmail.comLomonosov Moscow State UniversityМосковский государственный университет имени М.В. ЛомоносоваInstitute of Biomedical Problems of the Russian Academy of SciencesИнститут медико-биологических проблем РАН01052023109556157101022025Copyright ©; 2023, А.А. Швецова, Д.Д. Хухарева, С.Д. Симоненко, М.А. Хлыстова, А.А. Борзых, Д.К. ГайнуллинаCopyright ©; 2023, А.А. Швецова, Д.Д. Хухарева, С.Д. Симоненко, М.А. Хлыстова, А.А. Борзых, Д.К. Гайнуллина2023А.А. Швецова, Д.Д. Хухарева, С.Д. Симоненко, М.А. Хлыстова, А.А. Борзых, Д.К. ГайнуллинаА.А. Швецова, Д.Д. Хухарева, С.Д. Симоненко, М.А. Хлыстова, А.А. Борзых, Д.К. Гайнуллинаhttps://journals.eco-vector.com/0869-8139/article/view/651563

The normal functioning of the vascular system in early ontogenesis can be altered by adverse effects affecting the organism of the fetus / newborn during pregnancy, during or after childbirth. However, at the moment there is not enough data on the “acute” (immediately after exposure) and “delayed” (after several days) effects of short-term (within several hours) perinatal normobaric hypoxia on the functioning of the peripheral vascular system of the systemic circulation in early ontogenesis in mammals. The aim of this work was to study the “acute” and “delayed” effects of a single normobaric hypoxia on the functioning of the arteries of the systemic circulation in early postnatal ontogenesis. The contractile responses of the saphenous artery of rats aged 10–14 days were studied in isometric myograph. Acute normobaric hypoxia (8% O2) was simulated for 2 hours in 10-day-old rat pups. The selected hypoxia regimen did not lead to changes in arterial contractile responses to the α1-adrenergic agonist methoxamine either immediately after exposure or several days later. Endothelium-dependent relaxation of arteries to acetylcholine also did not differ between groups. Hypoxia did not change the contribution of anticontractile pathways associated with nitric oxide and Kv7 channels, as well as the pro contractile role of Rho-kinase. Thus, according to the presented results, short-term normobaric hypoxia on the 10th day of life in rat pups does not lead to either “acute” or “delayed” changes in the regulation of the tone of the peripheral arteries of the systemic circulation in the early postnatal period.

Нормальное функционирование сосудистой системы в раннем онтогенезе может изменяться при неблагоприятных воздействиях, влияющих на организм плода/новорожденного во время беременности, во время или после родов. Однако на настоящий момент недостаточно данных об “остром” (сразу после воздействия) и об “отставленном” (спустя несколько дней) влиянии непродолжительной (в течение нескольких часов) перинатальной нормобарической гипоксии на функционирование периферической сосудистой системы большого круга кровообращения в раннем онтогенезе у млекопитающих. Целью данной работы стало исследование “острых” и “отставленных” влияний однократной нормобарической гипоксии на функционирование артерий большого круга кровообращения в раннем постнатальном онтогенезе. В работе исследовали сократительные ответы подкожной артерии крыс в возрасте 10–14 дней в изометрическом режиме. Острую нормобарическую гипоксию (8% О2) моделировали в течение 2 ч у 10-дневных крысят. Выбранный режим гипоксии не привел к изменениям сократительных ответов артерий на агонист α1-адренорецепторов метоксамин ни сразу после воздействия, ни спустя несколько дней. Эндотелий-зависимое расслабление артерий на ацетилхолин также не различалось между группами. Гипоксия не привела к изменению выраженности антиконстрикторных путей, связанных с оксидом азота и Kv7-каналов, а также проконстрикторной роли Rho-киназы. Таким образом, согласно представленным в данной работе результатам, кратковременная нормобарическая гипоксия на 10-й день жизни крысят не приводит ни к “острым”, ни к “отставленным” изменениям в регуляции тонуса периферических сосудов большого круга кровообращения в раннем постнатальном периоде.

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