Russian Journal of PhysiologyRussian Journal of PhysiologyРоссийский физиологический журнал им. И.М. Сеченова0869-81392658-655XThe Russian Academy of Sciences65165810.31857/S0869813924030015CQBTSKREVIEWОБЗОРНЫЕ СТАТЬИReview ArticleMeta-Analysis of Experimental Studies of the Effect of Melatonin Monotherapy on Body Weight Gain and Eating Behavior in Rats on Different DietsМетаанализ экспериментальных исследований влияния монотерапии мелатонином на прирост массы тела и пищевое поведение крыс при различных диетахKuzmenkoN. V.КузьменкоН. В.
Russian Federation
nat.kuzmencko2011@yandex.ruTsyrlinV. A.ЦырлинВ. А.
Russian Federation
nat.kuzmencko2011@yandex.ruPlissM. G.ПлиссМ. Г.
Russian Federation
nat.kuzmencko2011@yandex.ruGalagudzaМ. М.ГалагудзаМ. М.
Russian Federation
nat.kuzmencko2011@yandex.ruAlmazov National Medical Research CentreНациональный медицинский исследовательский центр им. В. А. Алмазова Минздрава РоссииFirst Pavlov State Medical University of St. PetersburgПервый Санкт-Петербургский государственный медицинский университет им. академика И.П. Павлова Минздрава России15032024110329932501022025Copyright ©; 2024, Russian Academy of SciencesCopyright ©; 2024, Российская академия наук2024Russian Academy of SciencesРоссийская академия наукhttps://journals.eco-vector.com/0869-8139/article/view/651658

In an earlier meta-analysis, we showed that long-term melatonin administration minimizes diet-induced changes in lipid profiles. The purpose of our present work was to use a meta-analysis to investigate the effect of melatonin monotherapy on body weight gain (BWG) and eating behavior in rats depending on diet. To this end, we conducted a meta-analysis of 43 publications examining the effects of melatonin monotherapy on BWG, leptin levels, food and water intake in rats fed a standard diet (37 publications), as well as high-fructose diets (5 publications) and fats (9 publications). Our findings suggest that although melatonin reduced the level of triglycerides, total cholesterol and leptin in rats fed high-fructose and high-fat diets but not those fed a standard diet, melatonin treatment prevented BWG in rats on either diet. Increasing the dose of melatonin did not enhance the effect of therapy with any of the diets studied. We did not obtain convincing evidence that the effect of melatonin depends on the initial body weight and age of rats. On a standard diet, melatonin has been found to reduce food and water intake. Melatonin did not reduce BWG with a standard diet when administered intraperitoneally. Our research suggests that melatonin may be beneficial for diet-induced metabolic disorders by improving lipid profiles and preventing BWG. However, a decrease in appetite and BWG when taking melatonin may also be associated with negative side effects of the drug, which requires further research.

В раннее проведенном метаанализе мы показали, что длительное введение мелатонина минимизирует изменения в липидном профиле, вызванные диетой. Целью настоящей работы являлось с помощью метаанализа исследовать эффект монотерапии мелатонином на прирост массы тела (ПМТ) и пищевое поведение у крыс в зависимости от диеты. С этой целью мы провели метаанализ 43 публикаций, исследующих влияние монотерапии мелатонином на ПМТ, уровень лептина, потребление еды и воды у крыс, содержащихся на стандартной диете (37 публикаций), а также на диетах с повышенным содержанием фруктозы (5 публикаций) и жиров (9 публикаций). По итогам наших исследований, хотя мелатонин снижал уровень триглицеридов, общего холестерина и лептина у крыс, содержащихся на диетах с добавлением фруктозы и жиров, но не на стандартной диете, терапия мелатонином препятствовала набору массы тела крыс при любой диете. Увеличение дозы мелатонина не усиливало эффекта терапии ни при одной из исследованных диет. Мы не получили убедительных доказательств зависимости эффекта мелатонина от исходной массы тела и возраста крыс. Было установлено, что на стандартной диете мелатонин уменьшает потребление пищи и воды. Мелатонин не снижал ПМТ при стандартной диете, если вводился внутрибрюшинно. По итогам наших исследований, мелатонин может быть полезен при метаболических нарушениях, вызванных диетой, поскольку улучшает показатели липидного профиля и препятствует набору массы тела. Однако снижение аппетита и ПМТ при приеме мелатонина может быть связано и с отрицательными побочными эффектами препарата, что нуждается в дальнейших исследованиях.

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