Russian Journal of PhysiologyRussian Journal of PhysiologyРоссийский физиологический журнал им. И.М. Сеченова0869-81392658-655XThe Russian Academy of Sciences65165910.31857/S0869813924030024CQAQXXREVIEWОБЗОРНЫЕ СТАТЬИReview ArticleZebrafish аs а Promising Experimental Model of Traumatic Brain InjuryЗебраданио (Danio Rerio) как перспективная экспериментальная модель травматического повреждения мозгаShevlyakovA. D.ШевляковА. Д.
Russian Federation

Neurobiology Program and Immunobiology and Biomedicine Program

направления «Нейробиология» и «Иммунобиология и биомедицина»

avkalueff@gmail.comIlyinN. P.ИльинН. П.
Russian Federation
avkalueff@gmail.comGalstyanD. S.ГалстянД. С.
Russian Federation
avkalueff@gmail.comIkrinA. N.ИкринА. Н.
Russian Federation

Neurobiology Program and Immunobiology and Biomedicine Program

направления «Нейробиология» и «Иммунобиология и биомедицина»

avkalueff@gmail.comKolesnikovaT. O.КолесниковаТ. О.
Russian Federation

Neurobiology Program and Immunobiology and Biomedicine Program

направления «Нейробиология» и «Иммунобиология и биомедицина»

avkalueff@gmail.comApukhtinK. V.АпухтинК. В.
Russian Federation

Neurobiology Program and Immunobiology and Biomedicine Program

направления «Нейробиология» и «Иммунобиология и биомедицина»

avkalueff@gmail.comKotovaM. M.КотоваМ. М.
Russian Federation

Neurobiology Program and Immunobiology and Biomedicine Program

направления «Нейробиология» и «Иммунобиология и биомедицина»

avkalueff@gmail.comNikitinV. S.НикитинВ. С.
Russian Federation

Neurobiology Program and Immunobiology and Biomedicine Program

направления «Нейробиология» и «Иммунобиология и биомедицина»

avkalueff@gmail.comAmstislavskayaT. G.АмстиславскаяТ. Г.
Russian Federation
avkalueff@gmail.comPetersenE. V.ПетерсенЕ. В.
Russian Federation

Laboratory of Molecular Biological and Neurobiological Problems and Bioscreening

avkalueff@gmail.comKalueffA. V.КалуевА. В.
Russian Federation

Neurobiology Program and Immunobiology and Biomedicine Program

направления «Нейробиология» и «Иммунобиология и биомедицина»

avkalueff@gmail.comWorld-class Scientific Center “Center for Personalized Medicine”, Almazov National Medical Research Center, Ministry of HealthcareНаучный центр мирового уровня «Центр персонализированной медицины», Национальный медицинский исследовательский центр имени В. А. Алмазова МЗ РФScientific Center for Genetics and Life Sciences, Sirius University of Science and TechnologyНаучный центр генетики и наук о жизни, Научно-технологический университет «Сириус»Institute of Translational Biomedicine, St. Petersburg State UniversityИнститут трансляционной биомедицины, Санкт-Петербургский государственный университетInstitute of Experimental Medicine, Almazov National Medical Research Center, Ministry of HealthcareИнститут экспериментальной медицины, Национальный медицинский исследовательский центр имени В. А. Алмазова МЗ РФNeurobiology Program and Immunobiology and Biomedicine Program, Scientific Center for Genetics and Life Sciences, Sirius University of Science and TechnologyНаправления «Нейробиология» и «Иммунобиология и биомедицина», Научный центр генетики и наук о жизни, Научно-технологический университет «Сириус»Research Institute of Neuroscience and MedicineНИИ нейронаук и медициныMoscow Institute of Physics and TechnologyМосковский физико-технический институт15032024110332634801022025Copyright ©; 2024, Russian Academy of SciencesCopyright ©; 2024, Российская академия наук2024Russian Academy of SciencesРоссийская академия наукhttps://journals.eco-vector.com/0869-8139/article/view/651659

Traumatic brain injury (TBI) involves various types of physical injuries to brain tissue. TBI is a highly heterogeneous clinical condition, whose symptoms include cognitive, motor and emotional deficits, as well as neurodegeneration and neuroinflammation. Animal modeling plays a key role in studying TBI, expanding our knowledge of TBI and its temporal dynamics, and to develop new drugs for its treatment. Recently, the use of the bony zebrafish (Danio rerio) as an aquatic model organism has attracted particular interest in translational neurobiology. Zebrafish are presently second (after mice) laboratory animal species most used in biomedicine. Here, we discuss the prospects of using zebrafish to model TBI, as well as problems and new directions of research in this area. We also emphasize the importance of zebrafish as a highly translational model for studying the molecular mechanisms and neurological disorders in TBI, as well as screening for potential therapeutic agents.

Травматическое повреждение мозга (ТПМ) включает широкий спектр физических повреждений тканей мозга различной природы и сопровождается серьезными когнитивными, моторными, эмоциональными и нейродегенеративными нарушениями. Ключевую роль в изучении ТПМ играет его моделирование на животных, позволяя расширить наши знания о механизмах патогенеза и временной динамике последствий нейротравмы. В последнее время особый интерес в трансляционной нейробиологии вызывает использование в качестве модельного организма костистой рыбы зебраданио (zebrafish, Danio rerio) – второго после мышей наиболее используемого в биомедицине вида лабораторных животных. В работе обсуждаются проблемы и перспективы использования зебраданио для моделирования ТПМ, а также новые направления исследований в данной области. Отмечается значение зебраданио как перспективной модели для исследования молекулярных механизмов и неврологических нарушений при ТПМ, а также скрининге потенциальных терапевтических агентов.

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