Russian Journal of PhysiologyRussian Journal of PhysiologyРоссийский физиологический журнал им. И.М. Сеченова0869-81392658-655XThe Russian Academy of Sciences65166910.31857/S0869813924020016DKEXFVEXPERIMENTAL ARTICLESЭКСПЕРИМЕНТАЛЬНЫЕ СТАТЬИResearch ArticleTime scale of adaptation at the tonal sequence processing in the awake mice auditory cortex neuronsВременная шкала адаптации при обработке звуковых последовательностей нейронами первичной слуховой коры бодрствующих мышей (mus musculus)EgorovaМ. А.ЕгороваМ. А.
Russian Federation
ema6913@yandex.ruAkimovА. G.АкимовА. Г.
Russian Federation
ema6913@yandex.ruKhorunzhiiG. D.ХорунжийГ. Д.
Russian Federation
ema6913@yandex.ruSechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of SciencesИнститут эволюционной физиологии и биохимии им. И.М. Сеченова РАН15022024110215716801022025Copyright ©; 2024, Russian Academy of SciencesCopyright ©; 2024, Российская академия наук2024Russian Academy of SciencesРоссийская академия наукhttps://journals.eco-vector.com/0869-8139/article/view/651669

The study was firstly carried out on stimulus-specific adaptation of neurons in the primary and anterior fields of the awake house mice auditory cortex to sound sequences of four 100-ms tonal signals, with frequency of tones corresponding to the neuronal characteristic frequency, and also with the inter-tone interval constant for one sequence and varying from 0 to 2000 ms in different sequences. The analysis of the data obtained showed the adaptation effect in the responses of all studied primary auditory cortex neurons, which was observed as the absence or significant decrease in activity evoked by the components of a series of tones following the 1st, at inter-stimulus intervals of 0–500 ms. A quantitative assessment of the adaptation effects as a function of inter-stimulus intervals within the tonal sequence, performed over whole population of studied neurons, showed that the individual time scales of adaptation of neurons varied significantly, which may be crucial for the formation of optimal time windows for the processing of grouping and separation of sound events, which are important both for perception of animal vocalizations and human speech.

Впервые исследовали постстимульную слуховую адаптацию нейронов первичных полей слуховой коры у бодрствующих домовых мышей к звуковым последовательностям, образованным четырьмя 100-миллисекундными тональными сигналами, частота которых соответствовала характеристической частоте нейрона, интервал между тональными составляющими одной последовательности был одинаков, а в разных последовательностях варьировал от 0 до 2000 мс. Анализ полученных результатов продемонстрировал эффект адаптации в ответах подавляющего большинства исследованных нейронов, выражавшийся в отсутствие активности или значительном снижении активности, вызванной следующими за первым компонентами серии звуков, при межстимульных интервалах 0–500 мс. Количественная оценка проявления адаптации в зависимости от величины межстимульных интервалов в последовательности тонов по всей популяции исследуемых нейронов выявила сходство временных шкал адаптации бодрствующих и наркотизированных мышей.

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