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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Physiology</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Physiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский физиологический журнал им. И.М. Сеченова</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0869-8139</issn><issn publication-format="electronic">2658-655X</issn><publisher><publisher-name xml:lang="en">The Russian Academy of Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">651674</article-id><article-id pub-id-type="doi">10.31857/S0869813924020069</article-id><article-id pub-id-type="edn">DJLYNL</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>EXPERIMENTAL ARTICLES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ЭКСПЕРИМЕНТАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Methods for assessing the diastolic distensibility of the left ventricle</article-title><trans-title-group xml:lang="ru"><trans-title>Способы оценки диастолической упругости левого желудочка</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kapelko</surname><given-names>V. I.</given-names></name><name xml:lang="ru"><surname>Капелько</surname><given-names>В. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>v.lakomkin@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Lakomkin</surname><given-names>V. L.</given-names></name><name xml:lang="ru"><surname>Лакомкин</surname><given-names>В. Л.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>v.lakomkin@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Abramov</surname><given-names>А. А.</given-names></name><name xml:lang="ru"><surname>Абрамов</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>v.lakomkin@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Prosvirnin</surname><given-names>А. V.</given-names></name><name xml:lang="ru"><surname>Просвирнин</surname><given-names>А. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>v.lakomkin@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Chazov National Medical Research Center of Cardiology, Ministry of Healthcare</institution></aff><aff><institution xml:lang="ru">Национальный медицинский исследовательский центр кардиологии им. академика Е.И. Чазова Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2024-02-15" publication-format="electronic"><day>15</day><month>02</month><year>2024</year></pub-date><volume>110</volume><issue>2</issue><issue-title xml:lang="ru"/><fpage>230</fpage><lpage>237</lpage><history><date date-type="received" iso-8601-date="2025-02-01"><day>01</day><month>02</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Russian Academy of Sciences</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, Российская академия наук</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Russian Academy of Sciences</copyright-holder><copyright-holder xml:lang="ru">Российская академия наук</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/0869-8139/article/view/651674">https://journals.eco-vector.com/0869-8139/article/view/651674</self-uri><abstract xml:lang="en"><p>The most important property of the myocardium that determines the filling of the left ventricle (LV) of the heart is its distensibility. The simplest method of its assessment is the ratio of pressure and LV volume at the end of the diastole. Active relaxation of the myocardium is determined by the work of calcium pumps, and passive relaxation is determined by sarcomere proteins and, first of all, by connectin – titin. The paper compares 6 calculated indices of LV diastolic stiffness of the heart, compares their stability, variations and correlation coefficients from various parameters of hemodynamics. It is shown that only the diastolic stiffness index No. 4, which takes into account LV stiffness at the beginning and end of diastole, showed a weak dependence on LV, heart rate and other parameters of LV hemodynamics of the heart. Therefore, this index can be used in the future to assess the distensibility of the heart in various pathologies.</p></abstract><trans-abstract xml:lang="ru"><p>Важнейшим свойством миокарда, определяющим наполнение левого желудочка (ЛЖ) сердца, является его растяжимость. Наиболее простым методом ее оценки является соотношение давления и объема ЛЖ в конце диастолы, однако оно может варьировать в широком диапазоне и сильно зависит от условий притока и сопротивления, что затрудняет оценку растяжимости. В работе сопоставлены шесть расчетных индексов диастолической упругости ЛЖ сердца, большинство которых основано на законе Гука, сравнивается их устойчивость, разбросы и коэффициенты корреляции с различными параметрами гемодинамики. Оказалось, что только индекс диастолической упругости № 4, учитывающий прирост упругости ЛЖ в течение диастолы, показал слабую зависимость от фракции выброса, частоты сокращений и других параметров гемодинамики ЛЖ сердца, что обосновывает его применимость при оценке растяжимости при патологии сердца, сопровождающейся различными изменениями гемодинамики.</p></trans-abstract><kwd-group xml:lang="en"><kwd>myocardial extensibility</kwd><kwd>calculated indices of LV elasticity of the heart</kwd><kwd>titin</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>растяжимость миокарда</kwd><kwd>расчетные индексы упругости левого желудочка сердца</kwd><kwd>коннектин (титин)</kwd></kwd-group><funding-group><award-group><funding-source><institution-wrap><institution xml:lang="ru">Российский научный фонд</institution></institution-wrap><institution-wrap><institution xml:lang="en">Russian Science Foundation</institution></institution-wrap></funding-source><award-id>№ 23-15-00275</award-id></award-group><funding-statement xml:lang="en">This work was financed by the Russian Science Foundation grant No. 23-15-00275.</funding-statement><funding-statement xml:lang="ru">Данная работа финансировалась за счет средств гранта РНФ № 23-15-00275.</funding-statement></funding-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Lalande S, Mueller PJ, Chung CS (2017) The link between exercise and titin passive stiffness. 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