Russian Journal of PhysiologyRussian Journal of PhysiologyРоссийский физиологический журнал им. И.М. Сеченова0869-81392658-655XThe Russian Academy of Sciences65171010.31857/S0869813923110146AFGSLIREVIEW AND PROBLEM ARTICLESОБЗОРНЫЕ И ПРОБЛЕМНЫЕ СТАТЬИExperimental Models of Mitochondrial Dysfunction Disorders in the Pathogenesis of CNS Diseases on ZebrafishЭкспериментальные модели митохондриальных дисфункций при патогенезе болезней ЦНС на зебраданиоYushkoL. V.ЮшкоЛ. В.avkalueff@gmail.comKotovaM. M.КотоваМ. М.avkalueff@gmail.comVyunovaT. V.ВьюноваТ. В.avkalueff@gmail.comKalueffA. V.КалуевА. В.avkalueff@gmail.comDivision of Neurobiology, Sirius University of Science and TechnologyНаправление “Нейробиология”, Научный центр генетики и наук о жизни, Научно-технологический университет “Сириус”Life Improvement by Future Technologies Center “LIFT”Лаборатория технологий нейрореабилитации, Центр Life Improvement by Future Technologies “LIFT”Ural Federal UniversityУральский федеральный университетAlmazov National Medical Research Center, Ministry of Healthcare of Russian FederationНациональный медицинский исследовательский центр им. В.А. Алмазова МЗ РФInstitute of Translational Biomedicine, St. Petersburg State UniversityИнститут трансляционной биомедицины, Санкт-Петербургский государственный университет01112023109111617163401022025Copyright ©; 2023, Л.В. Юшко, М.М. Котова, Т.В. Вьюнова, А.В. КалуевCopyright ©; 2023, Л.В. Юшко, М.М. Котова, Т.В. Вьюнова, А.В. Калуев2023Л.В. Юшко, М.М. Котова, Т.В. Вьюнова, А.В. КалуевЛ.В. Юшко, М.М. Котова, Т.В. Вьюнова, А.В. Калуевhttps://journals.eco-vector.com/0869-8139/article/view/651710

Mitochondrial dysfunctions are associated with the pathogenesis of various brain disorders, including Alzheimer’s, Parkinson’s, Huntington’s, amyotrophic lateral sclerosis, Leigh syndrome and autism spectrum disorder. For the study of mitochondrial dysfunction and the development and testing of new therapeutic strategies, in vivo studies with zebrafish (Danio rerio) are of particular interest, due to their biological characteristics, practicality in laboratory maintenance, and high throughput. Here, we discuss genetic and pharmacological models of common mitochondrial dysfunctions and related neurological disorders in rodents and zebrafish, focusing of the growing utility of these fish in modeling mitochondrial pathogenesis of various CNS diseases.

Нарушения функций митохондрий в клетках мозга связаны с патогенезом заболеваний различной этиологии, в том числе болезней Альцгеймера, Паркинсона и Гентингтона, бокового амиотрофический склероза, синдрома Ли, аутизма и других. Для изучения митохондриальных дисфункций и создания новых терапевтических средств большое значение имеют исследования на животных. Помимо традиционных моделей на грызунах, пресноводная костная рыба зебраданио (zebrafish, Danio rerio) представляет особый интерес как модельный объект в силу своих биологических характеристик, практичности и возможности получить больший объем экспериментальных данных. В работе обсуждаются генетические и фармакологические модели митохондриальных дисфункций и связанных с ними неврологических расстройств на грызунах и зебраданио. Приведенные данные указывают на зебраданио как эффективную трансляционную модель для изучения патогенеза различных заболеваний мозга, связанных с митохондриальными дисфункциями.

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