Russian Journal of PhysiologyRussian Journal of PhysiologyРоссийский физиологический журнал им. И.М. Сеченова0869-81392658-655XThe Russian Academy of Sciences65173310.31857/S0869813924100084VRFIIMEXPERIMENTAL ARTICLESЭКСПЕРИМЕНТАЛЬНЫЕ СТАТЬИResearch ArticleEvent-related desynchronization of eeg sensorimotor rhythms in hemiparesis post-stroke patientsСвязанная с движением десинхронизация сенсомоторных ритмов ЭЭГ у пациентов с гемипарезом в результате инсультаMedvedevaА. S.МедведеваА. С.
Russian Federation
kolascoco@gmail.comSyrovN. V.СыровН. В.
Russian Federation
kolascoco@gmail.comYakovlevL. V.ЯковлевЛ. В.
Russian Federation
kolascoco@gmail.comAlievaY. А.АлиеваЯ. А.
Russian Federation
kolascoco@gmail.comPetrovaD. А.ПетроваД. А.
Russian Federation
kolascoco@gmail.comIvanovaG. Е.ИвановаГ. Е.
Russian Federation
kolascoco@gmail.comLebedevМ. А.ЛебедевМ. А.
Russian Federation
kolascoco@gmail.comKaplanА. Ya.КапланА. Я.
Russian Federation
kolascoco@gmail.comVladimir Zelman Center for Neurobiology and Brain Rehabilitation, Skolkovo Institute of Science and TechnologyЦентр нейробиологии и нейрореабилитации имени Владимира Зельмана Сколковского института науки и технологийLomonosov Moscow State UniversityМосковский государственный университет имени М. В. ЛомоносоваFederal Center of Brain Research and Neurotechnologies of the federal medical biological agencyФедеральный центр мозга и нейротехнологий ФМБА РоссииPirogov Russian National Research Medical UniversityРоссийский национальный исследовательский медицинский университет им. Н. И. Пирогова Минздрава РоссииSechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of SciencesИнститут эволюционной физиологии и биохимии им. И. М. Сеченова РАН15102024110101683170002022025Copyright ©; 2024, Russian Academy of SciencesCopyright ©; 2024, Российская академия наук2024Russian Academy of SciencesРоссийская академия наукhttps://journals.eco-vector.com/0869-8139/article/view/651733

Motor impairment is one of the most prevalent consequences of a stroke, necessitating the implementation of efficacious diagnostic and rehabilitative techniques. An evaluation of alterations in sensorimotor cortical activity during the processes of movement preparation and execution can provide valuable insights into the state of motor circuits following a stroke and the potential for recovery. The objective of the present study was to evaluate the spatiotemporal characteristics of event-related desynchronization (ERD) of sensorimotor EEG rhythms in patients with hemiparesis following a stroke, during movements with the paretic and healthy hands. A total of 19 patients with hemiparesis following a stroke participated in the study. An EEG was recorded while the subject performed a visual-motor task. The analysis focused on the event-related desynchronization in the alpha (6–15 Hz) and beta (15–30 Hz) bands. An asymmetry in the ERD was observed, with a predominant response in the intact hemisphere, regardless of the hand performing the movement. The magnitude of the ERD in the affected hemisphere demonstrated a correlation with the Fugl-Meyer score. Furthermore, a notable correlation was identified between the magnitude of beta-ERD in the affected hemisphere during movements of the healthy limb and the degree of motor function recovery. The results demonstrate the utility of ERD pattern assessment for diagnosing the state of sensorimotor networks after stroke. The detection of a correlation between the magnitude of ERD during movements of the healthy arm and the assessment of sensorimotor functions of the patient expands the possibilities of using EEG to assess patients even with complete absence of movements in the paretic limb.

Нарушение двигательной функции является одним из наиболее распространенных последствий инсульта и требует разработки эффективных методов диагностики и реабилитации. Оценка активности сенсомоторных отделов коры головного мозга во время подготовки и выполнения движений предоставляет важную информацию о состоянии двигательных областей после инсульта и потенциале восстановления. Целью настоящего исследования была оценка пространственно-временных характеристик связанной с событием десинхронизации (event-related desynchronization, ERD) сенсомоторных ритмов ЭЭГ у пациентов с гемипарезом после инсульта при движениях паретичной и здоровой руками. В исследовании приняли участие 19 пациентов с гемипарезом после инсульта. Регистрация ЭЭГ проводилась во время выполнения зрительно-моторной задачи. Анализировались реакции ERD в альфа- (6–15 Гц) и бета- (15–30 Гц) диапазонах. Была обнаружена асимметрия ERD с преобладанием реакции в интактном полушарии, независимо от того, какой рукой выполнялось движение. Величина альфа-/бета-ERD в пораженном полушарии коррелировала с оценкой по шкале Fugl-Meyer. Также была показана значимая корреляция между величиной бета-ERD в пораженном полушарии при движениях здоровой конечностью и степенью восстановления двигательной функции пораженной руки. Результаты демонстрируют информативность оценки паттернов ERD для диагностики состояния сенсомоторных сетей после инсульта и расширяют возможности использования ЭЭГ для оценки состояния пациентов даже с полным отсутствием движений в паретичной конечности.

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