Russian Journal of PhysiologyRussian Journal of PhysiologyРоссийский физиологический журнал им. И.М. Сеченова0869-81392658-655XThe Russian Academy of Sciences65174010.31857/S0869813924090015AKRXIXREVIEWОБЗОРНЫЕ СТАТЬИResearch ArticleAstrocyte marker GFAP in gliocytes of the peripheral nervous systemАстроцитарный маркер GFAP в глиоцитах периферической нервной системыPetrovaE. S.ПетроваЕ. С.
Russian Federation
iempes@yandex.ruKolosE. A.КолосЕ. А.
Russian Federation
iempes@yandex.ruInstitute of Experimental MedicineИнститут экспериментальной медицины1509202411091277129302022025Copyright ©; 2024, Russian Academy of SciencesCopyright ©; 2024, Российская академия наук2024Russian Academy of SciencesРоссийская академия наукhttps://journals.eco-vector.com/0869-8139/article/view/651740

The study of peripheral nervous system glial cells is an actual problem of modern neurobiology. The purpose of this work was to summarize our own and published data on the distribution of glial fibrillary acidic protein (GFAP) in peripheral nervous system (PNS) glial cells. The features of GFAP expression in glial cells of the enteric nervous system, dorsal root ganglion and peripheral nerve were examined. A comparative study of different populations of PNS gliocytes led to the conclusion that the intermediate filament protein GFAP is distributed differently in them. Analysis of the literature showed that despite the fact that this protein is widely used as a molecular marker of glial activation, there is still no understanding of the exact mechanisms of GFAP participation in the glial reactive response. The described features of GFAP+gliocytes from different parts of the PNS demonstrate the functional polymorphism of this protein. Its ability to be expressed in peripheral nervous system gliocytes in response to injury requires further research.

Исследование глиальных клеток периферической нервной системы (ПНС) является актуальной проблемой современной нейробиологии. Целью настоящей работы явилось обобщение собственных и литературных данных о распределении глиального фибриллярного кислого белка (GFAP) в клетках глии ПНС. Рассматривались особенности экспрессии GFAP в глии энтеральной нервной системы, спинномозгового ганглия и периферических нервных проводников. Сравнительное исследование разных популяций глиоцитов ПНС позволило заключить, что белок промежуточных филаментов GFAP распределяется в них по-разному. Анализ литературы показал, что несмотря на то, что данный белок широко применяется в качестве молекулярного маркера глиальной активации, до сих пор отсутствует понимание точных механизмов участия GFAP в глиальном реактивном ответе. Описанные особенности GFAP-содержащих глиоцитов различных отделов ПНС демонстрируют функциональный полиморфизм этого белка. Его свойство экспрессироваться в периферической глии в ответ на повреждение нуждается в дальнейших исследованиях.

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