Russian Journal of PhysiologyRussian Journal of PhysiologyРоссийский физиологический журнал им. И.М. Сеченова0869-81392658-655XThe Russian Academy of Sciences68623810.31857/S0869813925050013TOIYOIREVIEWОБЗОРНЫЕ СТАТЬИReview ArticlePossibilities and Limitations of Using the Olfactory Bulb Removal Model in RodentsВозможности и ограничения использования модели удаления обонятельных луковиц у грызуновNedogreevaO. A.НедогрееваО. А.
Russian Federation
nedogreewa_olga@gmail.comStepanichevM. Yu.СтепаничевМ. Ю.
Russian Federation
nedogreewa_olga@gmail.comInstitute of Higher Nervous Activity and Neurophysiology of the Russian Academy of SciencesИнститут высшей нервной деятельности и нейрофизиологии Российской академии наук1505202511156396582806202528062025Copyright ©; 2025, Russian Academy of SciencesCopyright ©; 2025, Российская академия наук2025Russian Academy of SciencesРоссийская академия наукhttps://journals.eco-vector.com/0869-8139/article/view/686238

Here, we review current data that provide a basis for using the olfactory bulbectomy model as a model of mental disorders in humans. Based on extensive literature and our own data, we have shown the possibilities of using the olfactory bulbectomy model in rodents as a model of depression and Alzheimer's disease, taking into account the correspondence of the observed changes with modern criteria of validity. The removal of olfactory bulbs causes a complex of molecular, structural, and behavioral changes in animals, which cannot serve as an ideal model for certain disease. The review discusses the limitations of using this model and interpreting the results. Nevertheless, this model can be a useful tool for both basic and applied studies of brain pathologies, taking into account these limitations.

В работе представлен обзор современных данных, которые дают основание для использования модели ольфакторной бульбэктомии в качестве модели психических нарушений у человека. На обширном материале литературных и собственных данных мы показали возможности использования модели ольфакторной бульбэктомии у грызунов в качестве модели депрессии и болезни Альцгеймера с учетом соответствия наблюдаемых изменений современным критериям валидности. Удаление обонятельных луковиц вызывает у животных сложный симптомокомплекс молекулярных, структурных и поведенческих изменений, который не может служить идеальной моделью определенного заболевания. В обзоре обсуждаются имеющиеся ограничения использования этой модели и интерпретации полученных с ее помощью результатов. Тем не менее эта модель может являться полезным инструментом как для фундаментальных, так и для прикладных исследований патологий мозга при соблюдении указанных ограничений.

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