Russian Journal of PhysiologyRussian Journal of PhysiologyРоссийский физиологический журнал им. И.М. Сеченова0869-81392658-655XThe Russian Academy of Sciences68627910.31857/S0869813925050096TNFGDOEXPERIMENTAL ARTICLESЭКСПЕРИМЕНТАЛЬНЫЕ СТАТЬИResearch ArticleThe GluN3A Subunit Forms GluN3A-NMDAR and the Excitatory Glycine Receptor in the Olfactory Sensory Neurons of Adult Wistar RatsGluN3A-субъединица образует GluN3A-NMDAR и возбуждающий глициновый рецептор в обонятельных сенсорных нейронах взрослых крыс линии ВистарBigdayE. V.БигдайЕ. В.
Russian Federation
bigday50@mail.ruZuykovaA. A.ЗуйковаА. А.
Russian Federation
bigday50@mail.ruBarmasovaA. M.БармасоваА. М.
Russian Federation
bigday50@mail.ruRazinovaA. A.РазиноваА. А.
Russian Federation
bigday50@mail.ruPozdnyakovA. V.ПоздняковА. В.
Russian Federation
bigday50@mail.ruIvanovD. O.ИвановД. О.
Russian Federation
bigday50@mail.ruSaint Petersburg State Pediatric UniversityСанкт-Петербургский государственный педиатрический медицинский университет1505202511157908052806202528062025Copyright ©; 2025, Russian Academy of SciencesCopyright ©; 2025, Российская академия наук2025Russian Academy of SciencesРоссийская академия наукhttps://journals.eco-vector.com/0869-8139/article/view/686279

The article presents experimental data obtained on isolated olfactory sensory neurons (OSN) of adult Wistar rats. The aim of the study was to show by in vivo fluorescent confocal microscopy using pharmacological analysis whether the GluN3A-subunit is localized in the olfactory sensory neurons of adult animals. Analysis of the results have revealed the presence of GluN3A-subunit in the OSN of adult rats as part of the excitatory glycine receptor and GluN3A containing N-methyl-D-aspartate receptor (GluN3A-NMDAR). In addition to them, the typical NMDAR and non-NMDAR are localized in the OSN. All these receptors can be located both in the same and in different receptor cells, which manifests the heterogeneity of the OSN in the olfactory epithelium.

В статье представлены экспериментальные данные, полученные на изолированных обонятельных сенсорных нейронах (ОСН) взрослых крыс линии Вистар. Цель исследования состояла в том, чтобы посредством прижизненной флуоресцентной конфокальной микроскопии с применением фармакологического анализа показать, локализуется ли GluN3A-субъединица в ОСН взрослых животных. Анализ полученных результатов выявил наличие в ОСН взрослых крыс субъединицы GluN3A в составе возбуждающего глицинового рецептора и GluN3A-содержащего N-метил-D-аспартатного рецептора (GluN3A-NMDAR). Помимо них, в ОСН локализуются типичный NMDAR и не-NMDAR. Все эти рецепторы могут располагаться как в одной и той же, так и в разных рецепторных клетках, в чем проявляется гетерогенность ОСН в обонятельном эпителии.

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