Russian Journal of PhysiologyRussian Journal of PhysiologyРоссийский физиологический журнал им. И.М. Сеченова0869-81392658-655XThe Russian Academy of Sciences69142610.7868/S2658655X25070017mvgldiREVIEWОБЗОРНЫЕ СТАТЬИResearch ArticleModern concepts of endoneurial fibroblastsСовременные представления о фибробластах эндоневрияPetrovaE. S.ПетроваЕ. С.iempes@yandex.ruKolosE. A.КолосЕ. А.Institute of Experimental MedicineИнститут экспериментальной медицины150720251117VOL 111, NO7 (2025)ТОМ 111, №7 (2025)995101726092025Copyright ©; 2025, Russian Academy of SciencesCopyright ©; 2025, Российская академия наук2025Russian Academy of SciencesРоссийская академия наукhttps://journals.eco-vector.com/0869-8139/article/view/691426

The purpose of this review was to summarize modern concepts of endoneurial fibroblasts of peripheral nerves and their role in reparative nerve regeneration. Along with Schwann cells and macrophages, fibroblasts are the main functionally significant cells of the endoneurium. There is little information in the literature on the characteristics of fibroblasts and their role in the regeneration of damaged nerves. Recent data on the morphofunctional features of endoneurial fibroblasts, their origin in ontogenesis and their functions are presented in the review. The characteristics of immunohistochemical markers used for their identification are presented. The necessity of studying the interactions of fibroblasts with other nerve cells is emphasized to clarify their role in nerve regeneration after injury.

Целью настоящего обзора явилось обобщение современных представлений о фибробластах эндоневрия периферических нервных проводников и их роли в репаративной регенерации нерва. Наряду со шванновскими клетками и макрофагами фибробласты являются основными по функциональной значимости клетками эндоневрия. В литературе имеется мало сведений об особенностях фибробластов и их роли в регенерации поврежденных нервных проводников. В обзоре представлены данные последних лет о морфофункциональных особенностях фибробластов эндоневрия, их происхождении в онтогенезе и их функциях. Дана характеристика иммуногистохимических маркеров, используемых для их идентификации. Подчеркивается необходимость исследования взаимодействий фибробластов с другими клетками нерва для выяснения их роли в регенерации нервных проводников после повреждения.

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