Russian Journal of PhysiologyRussian Journal of PhysiologyРоссийский физиологический журнал им. И.М. Сеченова0869-81392658-655XThe Russian Academy of Sciences69144310.7868/S2658655X25080041naejhjREVIEWОБЗОРНЫЕ СТАТЬИResearch ArticleThe Role of Dopamine in Chronic Pain: Neuroinflammation and NeurogenesisРоль дофамина при хронической боли: нейровоспаление и нейрогенезVetluginaA.ВетлугинаА.FokeevaN. O.ФокееваН. О.KochnevaA. A.КочневаА. А.KalueffA. V.КалуевА. В.MusienkoP. E.МусиенкоП. Е.GerasimovaE. V.ГерасимоваЕ. В.gerasimova.el.2011@yandex.ruDepartment of Neurobiology, Scientific Center of Genetics and Life Sciences, Sirius University of Science and TechnologyНаучный центр генетики и наук о жизни, направление “Нейробиология”, научно-технологический университет “Сириус”Institute of Translational Biomedicine, Saint Petersburg State UniversityИнститут трансляционной биомедицины, Санкт-Петербургский государственный университетLife Improvement by Future Technologies Center “LIFT”Federal Center of Brain Research and NeurotechnologiesФедеральный центр мозга и нейротехнологий150820251118VOL 111, NO (2025)ТОМ 111, № (2025)1296132126092025Copyright ©; 2025, Russian Academy of SciencesCopyright ©; 2025, Российская академия наук2025Russian Academy of SciencesРоссийская академия наукhttps://journals.eco-vector.com/0869-8139/article/view/691443

Chronic pain is a complex condition that directly affects the quality of life of patients. Regulation and treatment of chronic pain are associated with a number of difficulties, primarily due to the multifactorial nature of this condition. The causes of chronic pain can be associated not only with physical damage, such as various injuries, diseases and the development of neuroinflammation, but also with a violation of the synthesis of neurotransmitters, as well as complex processes of neurogenesis. In this review, we describe the complex and multifaceted interaction between dopaminergic regulation, neurogenesis and neuroinflammation on the development of chronic pain. Further studies of these relationships can lead to the creation of targeted therapeutic strategies aimed at eliminating chronic pain. Moreover, understanding the mechanisms underlying analgesia associated with the dopamine reward system can form the basis for the development of new therapeutic approaches to relieve and control pain.

Хроническая боль представляет собой сложное заболевание, непосредственно влияющее на качество жизни пациентов. Ее регуляция и лечение связаны с рядом трудностей, в первую очередь из-за многофакторности этого состояния. Причины хронической боли могут быть связаны не только с физическими повреждениями, такими как различные травмы, заболевания и развитие нейровоспаления, но и с нарушением синтеза нейромедиаторов, а также сложных процессов нейрогенеза. В данном обзоре описано сложное и многогранное взаимодействие между такими факторами, как дофаминергическая регуляция, нейрогенез, нейровоспаление и их влияние на развитие хронической боли. Дальнейшие исследования этих взаимосвязей могут привести к созданию целенаправленных терапевтических стратегий, направленных на устранение хронической боли, а понимание механизмов, лежащих в основе анальгезии, связанной с дофаминовой системой вознаграждения, может способствовать разработке новых терапевтических подходов для облегчения и контроля боли.

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