Importance of Bone Tissue Quality in Risk of Osteoporotic Fracture Development


Evaluation of the importance of quantitative and qualitative characteristics of bone in provision of its strength is given on the basis of the results of own studies of strength of the bioptates from the upper flaring portion of the ilium and literature review. Techniques for invasive and noninvasive evaluation of bone strength assessment and possibilities to use achieved data for the prognostication of risk of fractures that is important both scientifically and practically as enables to prescribe treatment timely are presented.

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Роль качества костной ткани в риске развития переломов при остеопорозе

About the authors

S. S Rodionova


  1. International Osteoporosis Foundation. Osteoporosis costs EU countries EU 37 billion every year. 2013. http:/ / 013-04/ iofoce041413.php.
  2. Макаров М.А. Влияние структурных и геометрических параметров проксимального отдела бедренной кости на риск возникновения переломов шейки бедра при остеопорозе: Автореф. дис.. канд. мед. наук. М.; 2000. [Makarov M.A. Influence of structural and geometric parameters of proximal femur on the risk of osteoporotic femoral neck fractures. Cand. med. sci. Diss. Moscow; 2000 (in Russian).]
  3. Frooznia H., Raffii M. Trabecular mineral content of the spine in women with hip fracture: CT measurement. Radiolodgy. 1986; 159: 737-40.
  4. Родионова С.С., Швец В.Н. Особенности потери костной ткани при системном остеопорозе (по данным гистоморфометрии). В кн.: Сборник материалов научнопрактической конференции «Метаболические остеопатии». М.; 1993: 57-9. [Rodionova S.S., Shvets V.N. Peculiarities of bone tissue loss in systemic osteoporosis (histomorphometric data). In: Metabolic osteopathies: Proc. Scientific-Practical Conf. Moscow; 1993: 57-9 (in Russian).]
  5. Макаров М.А. Влияние минеральной плотности костной ткани на риск переломов шейки бедра при остеопорозе. В кн.: Материалы третьего Российского симпозиума по остеопорозу. Санкт-Петербург; 2000: 148. [Makarov M.A. Influence of mineral bone density on the risk of osteoporotic femoral neck fractures. In: Proc. 3rd Russian Symp. On Osteoporosis. St. Petersburg; 2000: 148 (in Russian).]
  6. Chesnut III C.H., Skag A., Christiansen C., Recker R, Stakkestad J.A., Hoiseth A., Felsenberg D, Huss H., Gilbride J., Schimmer R.C., Delmas P.D. Effects of oral ibandronate administered daily or intermittently on fracture risk in postmenopausal osteoporosis. J. Bone Miner. Res. 2004; 19 (8): 1241-9.
  7. Hindso C., Lauritzen J. Risk and characteristics of falls among elderly orthopaedic patients. Osteoporosis Int. 1998; 8 (Supp 3): 18.
  8. Беляев Н.М. Сопротивление материалов. М.: Наука; 1976. [Belyaev N.M. Strength of materials. Moscow: Nauka; 1976 (in Russian).]
  9. Roque W., Arcaro K., Alberich-Bayarri A. Mechanical competence of bone: a new parameter to grade trabecular bone fragility from tortuosity and elasticity. IEEE Trans. Biomed. Eng. 2013; 60 (5): 1363-70.
  10. Bell K.L., Loveridge N., Power J., Garrahan N, Meggitt B.F., Reeve J. Regional differencis in cortical porosity in the fractured femoral neck. Bone. 1999; 24 (1): 57-64.
  11. Kleerekoper M., Villanueva A.R., Stanciu J., Rao D.S., Parfitt A.M. The role of threedimensional trabecular microstructures in the pathogenesis of vertebral compression fractures. Calcif. Tissue Int. 1985; 37: 594-7.
  12. Ciarelli T.E., Fyhrie D.P., Schaffler M.B., Goldstein S.A. Variations in three-dimensional cancellous bone architecture of the proximal femur in female hip fractures and controls. J. Bone Miner. Res. 2000; 15 (1): 32-40.
  13. Подрушняк Е.П., Новохацкая А.И. Ультраструктура минерального компонента и прочность костной ткани позвонков у людей различного возраста. Ортопедия травматология и протезирование. 1983; 8: 15-7. [Podrushnyak E.P., Novokhatskaya A.I. Ultrastructure of mineral component and vertebrae bone tissue strength in people of different age. Ortopediya, travmatologiya i protezirovanie. 1983; 8: 15-7 (in Russian).]
  14. Gourion-Arsiquaud S., Lukashova L., Power J., Loveridge N., Reeve J., Boskey A.L. Fourier transform infrared imaging of femoral neck bone: Reduced heterogeneity of mineral-to-matrix and carbonate-to-phosphate and more variable crystallinity in treatment-naive fracture cases compared with fracture-free controls. J. Bone Miner. Res. 2013; 28 (1): 150-61.
  15. Родионова С.С. Качество костной ткани как фактор риска переломов при остеопорозе. В кн.: Сборник тезисов III конференции «Проблемы остеопороза в травматологии и ортопедии». М.; 2006: 4. [Rodionova S.S. Bone tissue quality as risk factor of osteoporotic fractures In: Problems of osteoporosis in traumatology and orthopaedics: Proc. 3rd Conf. Moscow; 2006: 4 (in Russian).]
  16. Kazakia G.J., Nirody J.A., Bernstein G., Sode M., Burghardt A.J., Majumdar S. Age- and gender-related differences in cortical geometry and microstructure: Improved sensitivity by regional analysis. Bone. 2013; 52 (2): 623-31.
  17. Mashiba T., Turner C.H., Hirano T., Forwood M.R., Johnston C.C., Burr D.B. Effects of suppressed bone turnover by bisphosphonates on microdamage accumulation and biomechanical properties in clinically relevant skeletal sites in beagles. Bone. 2001; 28 (5): 524-31.
  18. Li Z.C., Dai L.Y., Jiang L.S., Qiu S. Difference in subchondral cancellous bone between postmenopausal women with hip osteoarthritis and osteoporotic fracture: Implication for fatigue microdamage, bonemicroarchitecture, and biomechanical properties. Arthritis Rheum. 2012; 64 (12): 3955-62.
  19. Партон В.З. Механика разрушения: от теории к практике. М.: Наука; 1990. [Parton V.Z. Destruction mechanics: from theory to practice. Moscow: Nauka; 1990 (in Russian).]
  20. Pasco J.A., Henry M.J., Sanders K.M., Kotowicz M.A., Seeman E., Nicholson G.C. b-adrenergic blockers reduce the risk of fracture partly by increasing bone mineral density: Geelong Osteoporosis Study. J. Bone Miner. Res. 2004; 19: 19-24.
  21. Zebaze R.M., Ghasem-Zadeh A., Bohte A., Iuliano-Burns S., Mirams M., Price R.I., Mackie E.J., Seeman E. Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: a cross-sectional study. Lancet. 2010; 375 (9727): 1729-36.
  22. Karunaratne A., Boyde A., Esapa C.T., Hiller J., Terrill N.J., Brown S.D., Cox R.D., Thakker R.V., Gupta H.S. Symmetrically reduced stiffness and increased extensibility in compression and tension at the mineralized fibrillar level in rachitic bone. Bone. 2013; 52 (2): 689-98.
  23. Chiang C.Y., Zebaze R.M., Ghasem-Zadeh A., Iuliano- Burns S., Hardidge A., Seeman E. Teriparatide improves bone quality and healing of atypical femoral fractures associated with bisphosphonate therapy. Bone. 2013; 52 (1): 360-5.
  24. Jiang Y., Genant H., Zhao J. et. al. 3D-microCT images. J. Bone Miner Res. 2006; 21 (suppl 1): S 44.
  25. Wehrli F.W., Ford J.C., Attie M., Kressel H.Y., Kaplan F.S. Trabecular structure: preliminary application MR interferometry. Radiology 1991; 79 (3): 615-22.
  26. Jeong H., Kim J., Ishida T., Akiyama M., Kim Y. Computerised analysis of osteoporotic bone patterns using texture parameters characterisingbone architecture. Br. J. Radiol. 2013; 86 (1021): 20101115.



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