N.N. Priorov Journal of Traumatology and OrthopedicsN.N. Priorov Journal of Traumatology and OrthopedicsВестник травматологии и ортопедии им. Н.Н. Приорова0869-86782658-6738Eco-Vector2588710.17816/vto202027157-76ArticlesСтатьиResearch ArticleTherapy of traumatic injuries of the spinal cord by magnetic nanoparticles: experimental aspects of promising technologyТерапия травматических повреждений спинного мозга магнитными наночастицами: экспериментальные аспекты перспективной технологииKolesovS. V.КолесовС. В.
Russian Federation
dr-kolesov@yandex.ruShvetsV. V.ШвецВ. В.
Russian Federation
dr-kolesov@yandex.ruSazhnevM. L.СажневМ. Л.
Russian Federation
dr-kolesov@yandex.ruPanteleevA. A.ПантелеевА. А.
Russian Federation
dr-kolesov@yandex.ruGorbatyukD. S.ГорбатюкД. С.
Russian Federation
dr-kolesov@yandex.ruN.N. Priorov National Medical Research Center of Traumatology and OrthopaedicsФГБУ «Национальный медицинский исследовательский центр травматологии и ортопедии им. Н.Н. Приорова» Минздрава России0104202027157760104202001042020Copyright ©; 2020, Eco-VectorCopyright ©; 2020, ООО "Эко-Вектор"2020Eco-VectorООО "Эко-Вектор"https://journals.eco-vector.com/0869-8678/article/view/25887

In this analytical review an attempt to sum up the available data in magnetite nanoparticle-marked stem cells utilization is made. Now this question remains on the experimental study level. Available data is diversified and needs an integral look to be taken. It is found that magnetite nanoparticles are non-toxic for the cells and do not interrupt physiological metabolic pathways. They can also be captured by cell using different transporters. Cells containing the magnetite nanoparticles can migrate along the magnetic flux lines. Animals with traumatic spinal cord lesions that got the nanoparticles-containing cell therapy showed the neurological status improvement. There is very little data in usage of this method in clinical practice; the solution of this problem requires more clinical trials.

В аналитическом обзоре предпринята попытка обобщения имеющихся данных по вопросу потенциального применения стволовых клеток, меченных магнитными наночастицами. В настоящее время эта проблема находится на экспериментальной стадии изучения, при этом имеющиеся сведения неоднородны и требуют обобщения для формирования целостного взгляда на проблему. Установлено, что магнитные наночастицы не характеризуются цитотоксичностью и значительным изменением физиологических процессов клеток, могут захватываться при помощи различных клеточных механизмов. Клетки, содержащие наночастицы, могут мигрировать (смещаться) в зависимости от плотности линий магнитного поля. У лабораторных животных с травматическим повреждением спинного мозга, которым в порядке эксперимента проводилась терапия стволовыми клетками, меченными магнитными наночастицами, было зарегистрировано статистически достоверное улучшение неврологических функций. Данные об использовании метода в клинической практике на текущий момент весьма ограничены; решение вопроса требует дальнейших исследований.

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