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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="data-paper" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">N.N. Priorov Journal of Traumatology and Orthopedics</journal-id><journal-title-group><journal-title xml:lang="en">N.N. Priorov Journal of Traumatology and Orthopedics</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник травматологии и ортопедии им. Н.Н. Приорова</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0869-8678</issn><issn publication-format="electronic">2658-6738</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">47272</article-id><article-id pub-id-type="doi">10.17816/vto201724147-57</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Scientific Report</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Draft Recommendations. Pharmacotherapy for the Prevention of Repeated Fractures in Patients with Osteoporosis after Surgical Treatment of Pathologic Proximal Femur Fracture</article-title><trans-title-group xml:lang="ru"><trans-title>Проект рекомендаций. Фармакотерапия для профилактики повторных переломов у больных остеопорозом после хирургического лечения патологического перелома проксимального отдела бедренной кости</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Mironov</surname><given-names>S. P</given-names></name><name xml:lang="ru"><surname>Миронов</surname><given-names>С. П</given-names></name></name-alternatives><bio xml:lang="ru"><p>академик РАН, доктор мед. наук, профессор, директор ЦИТО им. Н.Н. Приорова</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Rodionova</surname><given-names>S. S</given-names></name><name xml:lang="ru"><surname>Родионова</surname><given-names>Светлана Семеновна</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор мед. наук, профессор, рук. Центра остеопороза ЦИТО им. Н.Н. Приорова</p></bio><email>rod06@inbox.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Torgashin</surname><given-names>A. N</given-names></name><name xml:lang="ru"><surname>Торгашин</surname><given-names>А. Н</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. мед. наук, научный сотрудник Центра остеопороза ЦИТО им. Н.Н. Приорова</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.N. Priorov Central Institute of Traumatology and Orthopaedics</institution></aff><aff><institution xml:lang="ru">ФГБУ «Центральный научно-исследовательский институт травматологии и ортопедии им. Н.Н. Приорова» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2017-03-15" publication-format="electronic"><day>15</day><month>03</month><year>2017</year></pub-date><volume>24</volume><issue>1</issue><issue-title xml:lang="en">NO1 (2017)</issue-title><issue-title xml:lang="ru">№1 (2017)</issue-title><fpage>47</fpage><lpage>57</lpage><history><date date-type="received" iso-8601-date="2020-10-19"><day>19</day><month>10</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2017, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2017, ООО "Эко-Вектор"</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-Вектор"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2021-01-29"/></permissions><self-uri xlink:href="https://journals.eco-vector.com/0869-8678/article/view/47272">https://journals.eco-vector.com/0869-8678/article/view/47272</self-uri><abstract xml:lang="en"><p>Treatment of pathologic proximal femur fractures complicating the course of systemic osteoporosis is most often limited by surgical intervention as until now trauma and orthopaedic surgeons have no concrete recommendations on pharmacologic correction of metabolism disorders typical to the pathology, that aggravate in the postoperative period due to operative trauma. Proposed draft recommendations are a part of National clinical recommendations “Treatment for pathologic fractures of skeleton bones complicating the course of osteoporosis”. This issue of recommendations is only applicable to pharmacotherapy directed to the correction of bone tissue remodeling with regard for the fracture localization and volume of surgical intervention. Present recommendations are intended for the improvement of patients’ life quality, reduction of present and future losses from pathologic fracture as well as the prevention of repeated fractures.</p></abstract><trans-abstract xml:lang="ru"><p>Лечение патологических переломов проксимального отдела бедренной кости, осложняющих течение системного остеопороза, чаще всего ограничивается хирургическим вмешательством, так как травматологи-ортопеды до настоящего времени не имеют четких рекомендаций по фармакологической коррекции нарушений метаболизма, присущих заболеванию, которые в послеоперационном периоде усугубляются операционной травмой. Предлагаемый для обсуждения проект рекомендаций является частью Национальных клинических рекомендаций «Лечение патологических переломов различных костей скелета, осложняющих течение системного остеопороза». Этот раздел рекомендаций касается только фармакотерапии, направленной на коррекцию ремоделирования костной ткани с учетом локализации перелома и объема хирургического вмешательства. Данные рекомендации имеют своей целью повышение качества жизни пациентов, уменьшение настоящих и будущих экономических и социальных потерь от патологического перелома и профилактику повторных переломов.</p></trans-abstract><kwd-group xml:lang="en"><kwd>osteoporosis</kwd><kwd>pathologic fracture</kwd><kwd>clinical recommendations</kwd><kwd>antiresorptive therapy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>остеопороз</kwd><kwd>патологический перелом</kwd><kwd>клинические рекомен- дации</kwd><kwd>антирезорбтивная терапия</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Johnell O., Kanis J.A. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos. Int. 2006; 17 (12): 1726-33.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Singer A., Exuzides A., Spangler L. et al. Burden of illness for osteoporotic fractures compared with other serious diseases among postmenopausal women in the United States. Mayo Clin. Proc. 2015; 90 (1): 53-62.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Kanis J.A. Diagnosis of osteoporosis and assessment of fracture risk. Lancet. 2002; 359 (9321): 1929-36.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Eiben G., Dey D.K., Rothenberg E. et al. Obesity in 70-year-old Swedes: secular changes over 30 years. Int. J. Obes. (Lond). 2005; 29 (7): 810-7.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Gullberg B., Johnell O., Kanis J.A. World-wide projections for hip fracture. Osteoporos. Int. 1997; 7 (5): 407-13.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Leslie W.D., Morin S.N. Osteoporosis epidemiology 2013: implications for diagnosis, risk assessment, and treatment. Curr. Opin. Rheumatol. 2014; 26 (4): 440-6.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Ikeda K., Ogata E. Modulation of bone remodeling by active vitamin D: Its role in treatment of osteoporosis. Мech. Ageing Dev. 2000; 116 (2-3): 103-11.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Kim S.C., Kim M., Sanf_lix-Gimeno G. et al. Use of osteoporosis medications after hospitalization for hip fracture: a cross-national study. Am. J. Med. 2015; 128 (5): 519-26.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Solomon D.H., Johnston S.S., Boytsov N.N. et al. Osteoporosis medication use after hip fracture in U.S. patients between 2002 and 2011. J. Bone Miner. Res. 2014; 29 (9): 1929-37.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Scaglione M., Fabbri L., Di Rollo F. et al. The second hip fracture in osteoporotic patients: not only an orthopedic matter. Clin. Cases Miner. Bone Metab. 2013;10 (2): 124-8.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Kanis J.A., McCloskey E., Branco J. et al. Goal-directed treatment of osteoporosis in Europe. Osteoporos. Int. 2014; 25 (11): 2533-43.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Seeman E., Compston J., Adachi J. et al. Non-compliance: the Achilles’ heel of anti-fracture efficacy. Osteoporos. Int. 2007; 18 (6): 711-9.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Kim S.C., Kim M.S., Sanf_lix-Gimeno G. et al. Use of osteoporosis medications after hospitalization for hip fracture: a crossnational study. Am. J. Med. 2015; 128 (5): 519-26.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Cranney A., Wells G., Willan A. et al. Meta-analyses of therapies for postmenopausal osteoporosis. II. Meta-analysis of alendronate for the treatment of postmenopausal women. Endocr. Rev. 2002; 23 (4): 508-16.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Wells G.A., Cranney A., Peterson J. et al. Alendronate for the primary and secondary prevention of osteoporotic fr actures in postmenopausal women. Cochrane Database Syst. Rev. 2008; (1): CD001155.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Larsson S. Time to invest in a “fracture liaison nurse”! Injury. 2007; 38 (11): 1225-6.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Melton L.J. 3rd. Adverse outcomes of osteoporotic fractures in the general population. J. Bone Miner. Res. 2003; 18 (6): 1139-41.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Garnero P., Sornay-Rendu E., Claustrat B., Delmas P.D. Biochemical markers of bone turnover, endogenous hormones and the risk of fractures in postmenopausal women: the OFELY study. J. Bone Miner. Res. 2000; 15 (8): 1526-36.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Camacho P.M., Petak S.M., Binkley N. et al. American association of clinical endocrinologists and American college of endocrinology clinical practice guidelines for the diagnosis and treatment of postmenopausal osteoporosis - 2016. Endocr. Pract. 2016; 22 (Suppl 4): 1-42.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Borghi L., Schianchi T., Meschi T. et al. Comparison of two diets for the prevention of recurrent stones in idiopathic hypercalciuria. N. Engl. J. Med. 2002; 346 (2): 77-84.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Родионова С.С., Хакимов У.Р. Безопасность долгосрочного использования альфакальцидола при первичных формах системного остеопороза у мужчин. Клиническая геронтология. 2016; 5-6 (22): 27-33.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Родионова С.С., Буклемишев Ю.В. Эффективность золедроновой кислоты у пациентов с системным остеопорозом и проблема «неответчиков» лечения. Вестник травматологии и ортопедии им. Н.Н. Приорова. 2015; 4: 39-43.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Burch J., Rice S., Yang H. et al. Systematic review of the use of bone turnover markers for monitoring the response to osteoporosis treatment: the secondary prevention of fractures, and primary prevention of fractures in high- risk groups. Health Technol. Assess. 2014; 18 (11): 1-180.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Оглоблин Н.А., Спиричев В.Б., Батурин А.К. О потреблении населением России кальция с пищей. Вопросы питания. 2005; 5: 14-7.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Varenna M., Binelli L., Casari S. et al. Effects of dietary calcium intake on body weight and prevalence of osteoporosis in early postmenopausal women. Am. J. Clin. Nutr. 2007; 86 (3): 639-44.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Prince R.L., Devine A., Dhaliwal S.S. et al. Effects of calcium supplementation on clinical fracture and bone structure: results of a 5-year, double-blind, placebo- controlled trial in elderly women. Arch. Intern. Med. 2006; 166 (8): 869-75.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Prentice R.L., Pettinger M.B., Jackson R.D. et al. Health risks and benefits from calcium and vitamin D supplementation: Women’s Health Initiative clinical trial and cohort study. Osteoporos. Int. 2013; 24 (2): 567-80.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Tang B.M., Eslick G.D., Nowson C. et al. Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis. Lancet. 2007; 370 (9588): 657-66.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Micha_lsson K., Melhus H., Warensj_ Lemming E. et al. Long term calcium intake and rates of all cause and cardiovascular mortality: community based prospective longitudinal cohort study. BMJ. 2013; 346: f228.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Heaney R.P. Quantifying human calcium absorption using pharmacokinetic methods. J. Nutr. 2003; 133 (4): 1224-6.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Buclin T., Jacquet A.F., Burckhardt P. Intestinal absorption of calcium gluconate and oseine-mineral complex: an evaluation by conventional analyses. Schweiz. Med. Wochenschr. 1986; 116 (50): 1780-3 (in French).</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Fernandez-Pareja A., Hern_ndez-Blanco E., P_rez-Mace- da J.M. et al. Prevention of osteoporosis. Four year follow- up of a cohort of postmenopausal women treated with an ossein-hydroxyapatite compound. Clin. Drug Investig. 2007; 27 (4): 227-32.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Annefeld M., Caviezel R., Schacht E., Schicketanz K.H. The influence of ossein-hydroxyapatite compound (_Ossopan‘) on the healing of a bone defect. Curr. Med. Res. Opin. 1986;10 (4): 241-50.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Ciria-Recasens M., Blanch-Rubi_ J., Coll-Batet M. et al. Comparison of the effects of ossein-hydroapatite complex and calcium carbonate on bone metabolism in women with senile osteoporosis: a randomized, open- label, parallel-group, controlled, prospective study. Clin. Drug Investig. 2011; 31 (12): 817-24.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Castelo-Branco C., Ciria-Recasens M., Cancelo-Hidal- go M.J. et al. Efficacy of ossein-hydroxyapatit complex compared with calcium carbonate to prevent bone loss: a meta-analysis. Menopause. 2009; 16 (5): 984-91.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Wacker M., Holick M.F. Sunlight and Vitamin D: A global perspective for health. Dermatoendocrinol. 2013; 5 (1): 51-108.</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Pisani P., Renna M.D., Conversano F. et al. Fracture risk factors and impact. Major osteoporotic fragility fractures: Risk factor updates and societal impact. World J. Orthop. 2016; 7 (3): 171-81.</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Bischoff-Ferrari H.A., Dawson-Hughes B., Baron J.A. et al. Calcium intake and hip fracture risk in men and women: a meta-analysis of prospective cohort studies and randomized controlled trials. Am. J. Clin. Nutr. 2007; 86 (6): 1780-90.</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Nuti R., Bianchi G., Brandi M.L. et al. Superiority of alfacalcidol compared to vitamin D plus calcium in lumbar bone mineral density in postmenopausal osteoporosis. Rheumatol. Int. 2006; 26 (5): 445-53.</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Lau K.H., Baylink D.J. Treatment of 1,25(OH)2D3 (D-hormone) deficiency/resistance with D-hormone and analogs. Osteologie. 2001; 10: 28-39.</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Rix M., Eskildsen P., Olgaard K. Effect of 18 months of treatment with alfacalcidol on bone in patients with mild to moderate chronic renal failure. Nephrol. Dial Transplant. 2004; 19 (4): 870-6.</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Schacht E., Richy F., Reginster J.Y. The therapeutic effects of alfacalcidol on bone strength, muscle metabolism and prevention of falls and fractures. J. Musculoskelet. Neuronal. Interact. 2005; 5 (3): 273-84.</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Shiraishi A., Takeda S., Masaki T. et al. Alfacalcidol inhibits bone resorption and stimulates formation in an ovariectomized rat model of osteoporosis: distinct actions from estrogen. J. Bone Miner. Res. 2000; 15 (4): 770-9.</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Sakhaee K., Maalouf N., Kumar R. et al. Nephrolithiasis- associated bone disease: pathogenesis and treatment options. Kidney Int. 2011; 79 (4): 393-403.</mixed-citation></ref><ref id="B45"><label>45.</label><mixed-citation>Шварц Г.Я. Фармакотерапия остеопороза. М.: Медицинское информационное агентство; 2002.</mixed-citation></ref><ref id="B46"><label>46.</label><mixed-citation>Looker A.C., Melton L.J. 3rd, Borrud L.G., Shepherd J.A. Changes in femur neck bone density in US adults between 1988-1994 and 2005-2008: demographic patterns and possible determinants. Osteoporos. Int. 2012; 23 (2): 771-80.</mixed-citation></ref><ref id="B47"><label>47.</label><mixed-citation>Leslie W.D., Lix L.M., Yogendran M.S. et al. Temporal trends in obesity, osteoporosis treatment, bone mineral density, and fracture rates: a population-based historical cohort study. J. Bone Miner. Res. 2014; 29 (4): 952-9.</mixed-citation></ref><ref id="B48"><label>48.</label><mixed-citation>Родионова С.С., Нуждин В.И., Морозов А.К. и др. Остеопороз как фактор риска асептической нестабильности при эндопротезировании тазобедренного сустава. Вестник травматологии и ортопедии им. Н.Н. Приорова. 2007; 2: 35-40.</mixed-citation></ref><ref id="B49"><label>49.</label><mixed-citation>Grant A., Avenell A., Campbell M.K. et al. Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo- controlled trial. Lancet. 2005; 365 (9471): 1621-8.</mixed-citation></ref><ref id="B50"><label>50.</label><mixed-citation>Johnell O., Nilsson B., Obrant K., Sernbo I. Age and sex patterns of hip fracture - changes in 30 years. Acta Orthop. Scand. 1984; 55: 290-2.</mixed-citation></ref><ref id="B51"><label>51.</label><mixed-citation>Karlsson M., Hannavy K., Higgins C.F. A sequence-specific function for the N-terminal signal-like sequence of the TonB protein. Mol. Microbiol. 1993; 8 (2): 379-88.</mixed-citation></ref><ref id="B52"><label>52.</label><mixed-citation>Nishioka T., Yagi S., Mitsuhashi T. et al. Alendronate inhibits periprosthetic bone loss around uncemented femoral components. J. Bone Miner. Metab. 2007; 25 (3): 179-83.</mixed-citation></ref><ref id="B53"><label>53.</label><mixed-citation>Hallan G., Lie S.A., Havelin L.I. High wear rates and extensive osteolysis in 3 types of uncemented total hip arthroplasty: a review of the PCA, the Harris Galante and the Profile/Tri-Lock Plus arthroplasties with a minimum of 12 years median follow-up in 96 hips. Acta Orthop. 2006; 77 (4): 575-84.</mixed-citation></ref><ref id="B54"><label>54.</label><mixed-citation>Arabmotlagh M., Rittmeister M., Hennigs T. Alendronate prevents femoral periprosthetic bone loss following total hip arthroplasty: prospective randomized double-blind study. J. Orthop. Res. 2006; 24 (7): 1336-41.</mixed-citation></ref><ref id="B55"><label>55.</label><mixed-citation>Lyles K.W., Colon-Emeric C.S., Magaziner J.S. et al. Zoledronic acid inreducing clinical fracture and mortal- ity after hip fracture. N. Engl. J. Med. 2007; 357 (18); 1799- 809.</mixed-citation></ref><ref id="B56"><label>56.</label><mixed-citation>Cosman F., Cauley J., Eastell R. et al. Reassessment of fracture risk in women after 3 years of treatment with zoledronic acid: when is it reasonable to discontinue treatment? J. Clin. Endocrinol. Met. 2014; 99 (12): 4546-54.</mixed-citation></ref><ref id="B57"><label>57.</label><mixed-citation>Cosman F., Beur S. J., LeBoff M.S. et al. Clinician’s Guide to Prevention and Treatment of Osteoporosis. Osteoporos. Int. 2014; 25 (10): 2359-81.</mixed-citation></ref><ref id="B58"><label>58.</label><mixed-citation>Colon-Emeric C., Nordsletten L., Olson S. et al. Association between timing of zoledronic acid infusion and hip frac- ture healing. Osteoporos. Int. 2011; 22 (8): 2329-36.</mixed-citation></ref><ref id="B59"><label>59.</label><mixed-citation>Amanat N., McDonald M., Godfrey C. et al. Optimal timing of a singledose of zoledronic acid to increase strength in rat fracture repair. J. Bone Miner. Res. 2007; 22 (6): 867-76.</mixed-citation></ref><ref id="B60"><label>60.</label><mixed-citation>Egermann M., Goldhahn J., Schneider E. Animal models for fracture treatment in osteoporosis. Osteoporos. Int. 2005; 16 (Suppl 2): S129-38.</mixed-citation></ref><ref id="B61"><label>61.</label><mixed-citation>Durie B.G., Katz M., Crowley J. Osteonecrosis of the jaw and bisphosphonates. N. Engl. J. Med. 2005; 353 (1): 99- 102.</mixed-citation></ref><ref id="B62"><label>62.</label><mixed-citation>Gedmintas L., Solomon D.H., Kim S.C. Bisphosphonates and risk of subtrochanteric, femoral shaft, and atypical femur fracture: a systematic review and meta-analysis. J. Bone Miner. Res. 2013; 28 (8): 1729-37.</mixed-citation></ref><ref id="B63"><label>63.</label><mixed-citation>Dixon W.G., Solomon D.H. Bisphosphonates and esophageal cancer - a pathway through the confusion. Nat. Rev. Rheumatol. 2011; 7 (6): 369-72.</mixed-citation></ref><ref id="B64"><label>64.</label><mixed-citation>Grbic J.T., Landesberg R., Lin S.Q. et al. Incidence of osteonecrosis of the jaw in women with postmenopausal osteoporosis in the health outcomes and reduced incidence with zoledronic acid once yearly pivotal fracture trial. J. Am. Dent. Assoc. 2008; 139 (1): 32-40.</mixed-citation></ref><ref id="B65"><label>65.</label><mixed-citation>Imaz I., Zegarra P., Gonz_lez-Enr_quez J. et al. Poor bisphosphonate adherence for treatment of osteoporosis increases fracture risk: systematic review and meta- analysis. Osteoporos. Int. 2010; 21 (11): 1943-51.</mixed-citation></ref><ref id="B66"><label>66.</label><mixed-citation>Schilcher J., Aspenberg P. Incidence of stress fractures of the femoral shaft in women treated with bisphosphonate. Acta Orthop. 2009; 8 (4): 413-5.</mixed-citation></ref><ref id="B67"><label>67.</label><mixed-citation>Gerstenfeld L.C., Sacks D.J., Pelis M. et al. Comparison of effects of the bisphosphonate alendronate versus the RANKL inhibitor denosumab on murine fracture healing. J. Bone Miner Res. 2009; 24 (2): 196-208.</mixed-citation></ref><ref id="B68"><label>68.</label><mixed-citation>Cummings S.R., San Martin J., McClung M.R. et al. FREEDOM Trial. Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N. Engl. J. Med. 2009; 361 (8): 756-65.</mixed-citation></ref><ref id="B69"><label>69.</label><mixed-citation>Kendler D., Roux C., Benhamou C.L. et al. Effects of denosumab on bone mineral density and bone turnover in postmenopausal women transitioning from alendronate therapy. J. Bone Miner. Res. 2010; 25 (1): 72-81.</mixed-citation></ref><ref id="B70"><label>70.</label><mixed-citation>Massart F., Brandi M. Genetics of the bone response to bisphosphonate treatments. Clin. Cases Miner. Bone Metab. 2009; 6 (1): 50-4.</mixed-citation></ref><ref id="B71"><label>71.</label><mixed-citation>Miller P.D. A review of the efficacy and safety of denosumab in postmenopausal women with osteoporosis. Ther. Adv. Musculoskelet. Dis. 2011; 3 (6): 271-82.</mixed-citation></ref><ref id="B72"><label>72.</label><mixed-citation>Choi N.K., Solomon D.H., Tsacogianis T.N. et al. Comparative safety and effectiveness of denosumab versus zoledronic acid in patients with osteoporosis: a cohort study. J. Bone Miner. Res. 2017; 32 (3): 611-7.</mixed-citation></ref><ref id="B73"><label>73.</label><mixed-citation>Reid I.R. Denosumab after 8 years. Osteoporos. Int. 2015; 26 (12): 2759-61.</mixed-citation></ref><ref id="B74"><label>74.</label><mixed-citation>Gagnon C., Li V., Ebeling P.R. Osteoporosis in men: its pathophysiology and the role of teriparatide in its treatment. Clin. Interv. Aging. 2008; 3 (4): 635-45.</mixed-citation></ref><ref id="B75"><label>75.</label><mixed-citation>Bhandari M., Jin L., See K. et al. Does teriparatide improve femoral neck fracture healing: results from a randomized placebo-controlled trial. Clin. Orthop. Relat. Res. 2016; 474 (5): 1234-44.</mixed-citation></ref><ref id="B76"><label>76.</label><mixed-citation>Aspenberg P., Malouf J., Tarantino U. effects of teriparatide compared with risedronate on recovery after pertrochanteric hip fracture results of a randomized, active- controlled, double-blind clinical trial at 26 weeks. J. Bone Joint Surg. Am. 2016; 98 (22): 1868-78.</mixed-citation></ref><ref id="B77"><label>77.</label><mixed-citation>Eriksen E.F., Keaveny T.M., Gallagher E.R., Krege J.H. Literature review: The effects of teriparatide therapy at the hip in patients with osteoporosis. Bone. 2014; 67: 246-56.</mixed-citation></ref><ref id="B78"><label>78.</label><mixed-citation>Keaveny T.M., McClung M.R., Wan X. et al. Femoral strength in osteoporotic women treated with teriparatide or alendronate. Bone. 2012; 50 (1): 165-70.</mixed-citation></ref><ref id="B79"><label>79.</label><mixed-citation>Oteo-_lvaro _., Matas J.A., Alonso-Farto J.C. Teriparatide (rh [1-34] PTH) improved osteointegration of a hemiarthroplasty with signs of aseptic loosening. Orthopedics. 2011; 34 (9): e574-7.</mixed-citation></ref><ref id="B80"><label>80.</label><mixed-citation>Huang T.W., Chuang P.Y., Lin S.J. et al. Teriparatide improves fracture healing and early functional recovery in treatment of osteoporotic intertrochanteric fractures. Medicine (Baltimore). 2016; 95 (19): e3626.</mixed-citation></ref><ref id="B81"><label>81.</label><mixed-citation>Huang T.W., Yang T.Y., Huang K.C. et al. Effect of teriparatide on unstable pertrochanteric fractures. Biomed. Res. Int. 2015; (2015): 568390.</mixed-citation></ref><ref id="B82"><label>82.</label><mixed-citation>Ivaska K.K., Gerdhem P., Akesson K., Garnero P., Obrant K.J. Effect of fracture on bone turnover markers: a longitudinal study comparing marker levels before and after injury in 113 elderly women. J. Bone Miner. Res. 2007; 22 (8): 1155-64.</mixed-citation></ref><ref id="B83"><label>83.</label><mixed-citation>Mandema J.W., Zheng J., Libanati C., Perez Ruixo J.J. Time course of bone mineral density changes with denosumab compared with other drugs in postmenopausal osteoporosis: a dose-response-based meta-analysis. J. Clin. Endocrinol. Metab. 2014; 99 (10): 3746-55.</mixed-citation></ref></ref-list></back></article>
