N.N. Priorov Journal of Traumatology and OrthopedicsN.N. Priorov Journal of Traumatology and OrthopedicsВестник травматологии и ортопедии им. Н.Н. Приорова0869-86782658-6738Eco-Vector4770910.17816/vto201522151-69ArticlesСтатьиReview ArticleOrdinary and Activated Osteoplastic MaterialsОрдинарные и активированные остеопластические материалыDeevR. VДеевР. В

канд. мед. наук, директор по науке ИСКЧ

DrobyshevA. YuДробышевА. Ю

доктор мед. наук, профессор, зав. каф. челюстно-лицевой хирургии МГМСУ, засл. врач РФ

BozoI. YaБозоИлья Ядигерович

челюстно-лицевой хирург, аспирант кафедры челюстно-лицевой хирургии МГМСУ; Тел.: +7 (965) 437-89-46.

bozo.ilya@gmail.comHuman Stem Cells Institute, MoscowОАО «Институт стволовых клеток человека»A.I. Evdokimov Moscow State University of Medicine and Dentistry, MoscowГБОУ ВПО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова»15032015221NO1 (2015)ТОМ 22, №1 (2015)516920102020Copyright ©; 2015, Eco-VectorCopyright ©; 2015, ООО "Эко-Вектор"2015Eco-VectorООО "Эко-Вектор"https://journals.eco-vector.com/0869-8678/article/view/47709

Osteoplastic materials are highly required medical devices for bone defects substitution and filling the areas of bone tissue atrophy. Based on analysis of modern groups of osteoplastic materials, features of their composition, mechanisms of biological action, and indications for clinical use, the applied classification which divides the medical items into ordinary and activated categories is proposed. The main differential criterion is the presence of certain biologically active components in the material composition: growth factors, cells or gene constructions encoding growth factors that are standardized by qualitative and quantitative parameters. Pronounced osteoinductive and (or) osteogenic properties of activated osteoplastic materials enable counting on their effectiveness in replacement of large bone defects.

Остеопластические материалы являются высоко востребованными в клинической практике медицинскими изделиями, показанными для замещения костных дефектов и восполнения участков атрофии костной ткани. На основе анализа современных групп остеопластических материалов, особенностей их состава, механизмов биологического действия и показаний к применению предложена прикладная классификация, в соответствии с которой медицинские изделия разделяются на ординарные и активированные. Основным дифференциальным критерием является наличие в составе материала стандартизированных по качественным и количественным параметрам биологически активных компонентов: факторов роста, клеток или генных конструкций, кодирующих факторы роста. Выраженные остеоиндуктивные и (или) остеогенные свойства активированных остеопластических материалов позволяют рассчитывать на их эффективность при замещении протяженных (объемных) костных дефектов.

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