N.N. Priorov Journal of Traumatology and OrthopedicsN.N. Priorov Journal of Traumatology and OrthopedicsВестник травматологии и ортопедии им. Н.Н. Приорова0869-86782658-6738Eco-Vector63203210.17816/vto632032SCIENTIFIC REVIEWSНаучные обзорыReview ArticleLocal antibacterial depot systems in the treatment of bone and joint infection (review)Локальные антибактериальные депо-системы в лечении костно-суставной инфекции (обзор литературы)https://orcid.org/0000-0002-5283-70788288-0256MelikovaRegina E.МеликоваРегина Энверпашаевна
Russian Federation

MD, Cand. Sci. (Medicine)

канд. мед. наук

regina-melikova@mail.ruhttps://orcid.org/0000-0003-1721-282X2312-1002TsiskarashviliArchil V.ЦискарашвилиАрчил Важаевич
Russian Federation

MD, Cand. Sci. (Medicine)

канд. мед. наук

armed05@mail.ruPriorov Central Research Institute of Traumatology and OrthopedicsНациональный медицинский исследовательский центр травматологии и ортопедии им. Н.Н. Приорова19112024251220243146776951605202424052024Copyright ©; 2024, Eco-VectorCopyright ©; 2024, Эко-Вектор2024Eco-VectorЭко-Векторhttps://eco-vector.com/for_authors.php#07https://journals.eco-vector.com/0869-8678/article/view/632032

Local depot systems with high antibiotic content are an essential component of combination therapy in osteoarticular infections. These systems are effective against microbial biofilms by providing drug concentrations that surpass the requirements of planktonic bacteria. Currently, there are numerous support matrixes with various properties. Only a few of them are sufficiently studied and actively used in clinical practice. These include polymethylmethacrylate-based bone cement, calcium sulfate, collagen, allografts, etc. However, the vast majority of local systems have only been studied in vitro and in vivo. This review describes currently available depot systems, including their primary properties, advantages, and disadvantages, as well as potential for future use of a specific matrix both for the treatment and prevention of diseases.

Локальные депо-системы, насыщенные антибиотиками, являются неотъемлемой частью комплексного лечения костно-суставной инфекции, поскольку позволяют эффективно бороться с микробными биоплёнками путём создания концентрации препаратов, многократно превышающей необходимые для планктонных форм микроорганизмов. В настоящее время существует множество несущих матриц, обладающих различными свойствами. Лишь небольшая часть из них достаточно хорошо изучена и активно применяется в клинической практике — к таковым относятся костный цемент на основе полиметилметакрилата, сульфат кальция, коллаген, аллографты и др. Подавляющее же большинство локальных систем исследованы только в условиях in vitro и in vivo. Данный обзор посвящён описанию существующих на сегодняшний день депо-систем, их основных свойств, преимуществ и недостатков, а также возможных перспектив дальнейшего применения той или иной матрицы как в условиях лечения, так и в профилактических целях.

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