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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">N.N. Priorov Journal of Traumatology and Orthopedics</journal-id><journal-title-group><journal-title xml:lang="en">N.N. Priorov Journal of Traumatology and Orthopedics</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник травматологии и ортопедии им. Н.Н. Приорова</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0869-8678</issn><issn publication-format="electronic">2658-6738</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">99998</article-id><article-id pub-id-type="doi">10.17816/vto99998</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>SCIENTIFIC REVIEWS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Научные обзоры</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Modern possibilities of optimizing reparative bone tissue regeneration</article-title><trans-title-group xml:lang="ru"><trans-title>Современные возможности оптимизации репаративной регенерации костной ткани</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Omelyanenko</surname><given-names>N. P.</given-names></name><name xml:lang="ru"><surname>Омельяненко</surname><given-names>Н. П.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Mironov</surname><given-names>S. P.</given-names></name><name xml:lang="ru"><surname>Миронов</surname><given-names>С. П.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Denisov-Nikolsky</surname><given-names>Yu. I.</given-names></name><name xml:lang="ru"><surname>Денисов-Никольский</surname><given-names>Ю. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Matveychuk</surname><given-names>I. V.</given-names></name><name xml:lang="ru"><surname>Матвейчук</surname><given-names>И. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Dorokhin</surname><given-names>A. I.</given-names></name><name xml:lang="ru"><surname>Дорохин</surname><given-names>А. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Karpov</surname><given-names>N. N.</given-names></name><name xml:lang="ru"><surname>Карпов</surname><given-names>Н. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Central Institute of Traumatology and Orthopedics. N.N. Priorov</institution></aff><aff><institution xml:lang="ru">Центральный институт травматологии и ортопедии им. Н.Н. Приорова</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Research Center for Biomedical Technologies</institution></aff><aff><institution xml:lang="ru">Научно-исследовательский центр биомедицинских технологий</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2002-12-15" publication-format="electronic"><day>15</day><month>12</month><year>2002</year></pub-date><volume>9</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>85</fpage><lpage>88</lpage><history><date date-type="received" iso-8601-date="2022-02-01"><day>01</day><month>02</month><year>2022</year></date><date date-type="accepted" iso-8601-date="2022-02-01"><day>01</day><month>02</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2022, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2022, ООО "Эко-Вектор"</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-Вектор"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://journals.eco-vector.com/0869-8678/article/view/99998">https://journals.eco-vector.com/0869-8678/article/view/99998</self-uri><abstract xml:lang="en"><p>Reparative regeneration of bone tissue is characterized by a multi-stage course. From the moment of bone damage to the completion of repair, i.e. Before the formation of morphologically mature bone tissue, which fills the bone defect, and the full restoration of bone function, a lot of time passes. At the same time, the general patterns of the development of the reparative process are clearly traced, and the specific features depend on the conditions in which it proceeds and on the potencies of osteogenic cellular elements.</p></abstract><trans-abstract xml:lang="ru"><p>Репаративная регенерация костной ткани характеризуется многоэтапностью течения. От момента повреждения кости до завершения репарации, т.е. до образования морфологически зрелой костной ткани, заполняющей костный дефект, и полноценного восстановления функции кости, проходит достаточно много времени. При этом четко прослеживаются общие закономерности развития репаративного процесса, а специфические особенности зависят от условий, в которых он протекает, и от потенций остеогенных клеточных элементов.</p></trans-abstract><kwd-group xml:lang="en"><kwd>reparative regeneration of bone tissue</kwd><kwd>bone damage</kwd><kwd>osteoblastic osteogenesis</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>репаративная регенерация костной ткани</kwd><kwd>повреждения кости</kwd><kwd>остеобластический остеогенез</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Амелин А.З., Лоцева Е.Н. //Ортопед, травматол. — 1980. — N3. — С. 35-37.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Балаболкин М.И. Эндокринология. — М., 1998.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Болтрукевич С.И. //Здравоохр. 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