Current Medicinal ChemistryCurrent Medicinal ChemistryCurrent Medicinal Chemistry0929-86731875-533XBentham Science64514810.2174/0109298673283640231208103306Anti-Infectives and Infectious DiseasesResearch ArticleIs Oxidized Low-Density Lipoprotein a Principal Actor in Atherogenesis?OrekhovAlexanderinfo@benthamscience.netSukhorukovVasilyinfo@benthamscience.netMelnichenkoAlexandrainfo@benthamscience.netLaboratory of Angiopatology, Institute of General Pathology and PathophysiologyLaboratory of Angiopatology,, Institute of General Pathology and Pathophysiology1011202431426909691007012025Copyright ©; 2024, Bentham Science Publishers2024Bentham Science Publishershttps://journals.eco-vector.com/0929-8673/article/view/645148Atherogenesisautoantibodies against LDLdesialylated LDLelectronegative LDLmalondialdehyde treated LDLmultiple-modified LDLoxidized LDLsmall dense LDL.[Sahebkar, A.; Kiani, Z.; Rouhani, M.H.; Mahdavi, A.; Askari, G.; Jamialahmadi, T.; Bagherniya, M. The effect of probiotics on oxidized LDL levels: A systematic review and meta-analysis of clinical trials. Curr. Med. Chem., 2023. Ahead of Print. doi: 10.2174/0929867331666230815104548 PMID: 37581525][Steinberg, D. Low density lipoprotein oxidation and its pathobiological significance. J. Biol. Chem., 1997, 272(34), 20963-20966. doi: 10.1074/jbc.272.34.20963 PMID: 9261091][Palinski, W.; Rosenfeld, M.E.; Ylä-Herttuala, S.; Gurtner, G.C.; Socher, S.S.; Butler, S.W.; Parthasarathy, S.; Carew, T.E.; Stein-berg, D.; Witztum, J.L. Low density lipoprotein undergoes oxidative modification in vivo. Proc. Natl. Acad. Sci., 1989, 86(4), 1372-1376. doi: 10.1073/pnas.86.4.1372 PMID: 2465552][Orekhov, A.N.; Tertov, V.V.; Kabakov, A.E. Adamova IYu; Pokrovsky, S.N.; Smirnov, V.N. Autoantibodies against modified low density lipoprotein. Nonlipid factor of blood plasma that stimulates foam cell formation. Arterioscler. Thromb., 1991, 11(2), 316-326. doi: 10.1161/01.ATV.11.2.316 PMID: 1998649][Avogaro, P.; Bon, G.B.; Cazzolato, G. Presence of a modified low density lipoprotein in humans. Arteriosclerosis, 1988, 8(1), 79-87. doi: 10.1161/01.ATV.8.1.79 PMID: 3341993][Krauss, R.M. Heterogeneity of plasma low-density lipoproteins and atherosclerosis risk. Curr. Opin. Lipidol., 1994, 5(5), 339-349. doi: 10.1097/00041433-199410000-00005 PMID: 7858908][Tertov, V.V.; Sobenin, I.A.; Gabbasov, Z.A.; Popov, E.G.; Jaakkola, O.; Solakivi, T.; Nikkari, T.; Smirnov, V.N.; Orekhov, A.N. Multiple-modified desialylated low density lipoproteins that cause intracellular lipid accumulation. Isolation, fractionation and characterization. Lab. Invest., 1992, 67(5), 665-675. PMID: 1434544]