Current Medicinal ChemistryCurrent Medicinal ChemistryCurrent Medicinal Chemistry0929-86731875-533XBentham Science64515910.2174/0109298673269428231204064101Anti-Infectives and Infectious DiseasesResearch ArticlePerillyl Alcohol Promotes Relaxation in Human Umbilical Arteryde Sena BastosCarlainfo@benthamscience.netPereira-de-MoraisLuisinfo@benthamscience.netde Alencar SilvaAndressainfo@benthamscience.netde Menezes DantasDéborainfo@benthamscience.netBatistaPauloinfo@benthamscience.netGomesMariainfo@benthamscience.netde Araújo DelmondesGyllyandesoninfo@benthamscience.netde MenezesIrwininfo@benthamscience.netda SilvaRenatainfo@benthamscience.netBarbosaRoseliinfo@benthamscience.netBiological Chemistry Department, Pimenta Campus, Regional University of CaririPhysiopharmacology of Excitable Cells Laboratory, Biological Sciences Department, Pimenta Campus, Regional University of CaririNursing Collegiate, Petrolina Campus, Federal University of The San Francisco Vale1011202431427072708207012025Copyright ©; 2024, Bentham Science Publishers2024Bentham Science Publishershttps://journals.eco-vector.com/0929-8673/article/view/645159

Background:Perillyl alcohol (POH) is a monoterpenoid found in plant essential oils and has been shown to relax murine vessels, but its effect on human vessels remains poorly studied.

Objective:The study aimed to characterize the effect of POH on human umbilical arteries (HUA).

Methods:Rings of HUA were obtained from uncomplicated patients and suspended in an organ bath for isometric recording. The vasorelaxant effect of POH in HUA was evaluated on basal tone and electromechanical or pharmacomechanical contractions, and possible mechanisms of action were also investigated.

Results:POH (1-1000 µM) altered the basal tone of HUA and completely relaxed HUA rings precontracted with KCl (60 mM) or 5-HT (10 µM), obtaining greater potency in the pharmacomechanical pathway (EC50 110.1 µM), suggesting a complex interference in the mobilization of extra- and intracellular Ca2+. POH (1000 µM) inhibited contractions induced by BaCl2 (0.1-30 mM) in a similar way to nifedipine (10 µM), indicating a possible blockade of L-type VOCC. In the presence of potassium channel blockers, tetraethylammonium (1 mM), 4-aminopyridine (1 mM), or glibenclamide (10 µM), an increase in the EC50 value of the POH was observed, suggesting a modulation of the activity of BKCa, KV, and KATP channels.

Conclusion:The data from this study suggest that POH modulates Ca2+ and K+ ion channels to induce a relaxant response in HUA.

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