Neurology BulletinNeurology Bulletin1027-48982304-3067Eco-Vector1375710.17816/nb13757THERAPY IN PATIENTS WITH NEWLY DIAGNOSED PARANOID SCHIZOPHRENIABlednihMaria AThe St.Petersburg V.M. Bekhterev Psychoneurological Research Institutem.blednih@yandex.ruThe St.Petersburg V.M. Bekhterev Psychoneurological Research Institute15062012XLIV2929420062019Copyright © 2012, Blednih M.A.2012The paper identified the main factors that influenced the development of acute symptoms of schizophrenia and adherence to therapy in patients with newly diagnosed paranoid schizophrenia who took psychoactive drugs at the time of the first symptoms. High risk of recurrence was exposed in those patients with paranoid schizophrenia who use drugs. A comprehensive approach to therapy was offered in this group of patients.psychoactive drugsrelapsecomorbidityschizophreniaadherence to therapyпсихоактивные средстварецидивкоморбидностьшизофренияприверженность к терапии[1. Лутова Н.Б., Борцов А.В., Вукс А.Я., Вид В.Д. Метод прогнозирования медикаментозного комплаенса в психиатрии / Метод. реком. - Санкт-Петербургский научно-исследовательский психоневрологический институт им. В.М.Бехтерева, 2007. - 26 с.][2. Gregg L., Barrowclough C., Haddock G. Reasons for increased substance use in psychosis // Clin. Psycho Rev. - 2007. - Vol. 27. - P.494-510.][3. Kay S.R., Fiszbein A., Opler L.A. The positive and negative syndrome scale (PANSS) for schizophrenia // Schizophr Bull. - 1987. - Vol. 13(2). - P. 261-276.][4. Koskinen J., Lцhцnen J., Koponen H. et al. Rate of Cannabis Use Disorders in Clinical Samples of Patients With Schizophrenia: A Meta-analysis // Schizophr Bull. - 2009. - PubMed PMID:19386576.][5. Meister K., Burlon M., Rietschel L. et al. Dual diagnosis psychosis and substance use disorders in adolescents // Fortschr Neurol Psychiatr. - 2010 Feb. - Vol. 78(2). - P. 90-100.][6. Morosini P.L. et al. Development, reliability and acceptability of a new version of the DSM-IV Social and Occupational Functioning Assessment Scale (SOFAS) to assess routing social functioning // Acta Psychiatr Scan. - 2000. - Vol. 101. - P. 323-329.][7. Reiger D.A., Farmer M.E., Rae D.S. et al. Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiological Catchment Area (ECA) Study // JAMA. - 1990. - Vol. 264. - P. 2511-2518.][8. Westermeyer J. Comorbid Schizophrenia and Substance Abuse: A Review of Epidemiology and Course // Am. J. Addict. - 2006. - Vol.15. - P. 345-355.]