Neurology BulletinNeurology Bulletin1027-48982304-3067Eco-Vector1390610.17816/nb13906Research ArticleCORRELATION OF AGGRESSION AND REGIONAL GLUCOSE METABOLISM RATES OF PATIENTS WITH EPILEPSYSusinDaniil Sspb@gpma.ruKataevaGalina Voffice@ihb.spb.ruReznikovaTatyana Noffice@ihb.spb.ruSeliverstovaNatalya Aoffice@ihb.spb.ruPlotnikovaIrina Voffice@ihb.spb.ruLytaevSergei Aspb@gpma.ru1) Saint-Petersburg State Pediatric Medical University2) Institute of the Human Brain, Russian Academy of SciencesInstitute of the Human Brain, Russian Academy of SciencesSaint-Petersburg State Pediatric Medical University15062015XLVII2212520062019Copyright © 2015, Susin D.S., Kataeva G.V., Reznikova T.N., Seliverstova N.A., Plotnikova I.V., Lytaev S.A.2015The article is dedicated to the investigation of the interconnection of and the regional glucose metabolism rates of the human brain in the patients with epilepsy. We have managed to reveal that epileptic patients in the quiet wake state demonstrate a rise of different types of aggression, which is mostly correlated with the glucose metabolism change in the left hemisphere of brain. With the rise of physical and verbal aggression, the increase of the left parietal lobe metabolic rate and the decrease of the left occipital cortex metabolic rate have been registered. Enhanced hostility, soreness, negativism, and suspicion are correlated with the decrease of the left prefrontal cortex glucose metabolism rate.aggressionglucose metabolism ratehuman brainepilepsyPETагрессияуровень метаболизма глюкозыголовной мозгэпилепсияпозитронно-эмиссионная томография[Гомзина Н.А., Васильев Д.А., Красикова Р.Н. Оптимизация роботизированного синтеза 2-[18F]фтор-2-дезокси-D-глюкозы на основе щелочного гидролиза // Радиохимия. 2002. № 44(6). C. 527-532.][Катаева Г.В., Коротков А.Д., Мельничук К.В. Паттерны относительных оценок регионарного мозгового кровотока и скорости метаболизма глюкозы в здоровом мозге человека // Медицинская визуализация. 2007. № 2. С. 84-92.][Пакет программ SPM. URL: www.fil.ion.ucl.ac.uk/spm/ (дата обращения 01.09.2014).][Программа WFU PicAtlas. URL: www.nitrc.org/projects/wfu_pickatlas/ (дата обращения 01.09.2014).][Alper K.R., Barry J.J., Balabanov A.J. Treatment of psychosis, aggression, and irritability in patients with epilepsy // Epilepsy Behav. 2002. № 3(5). P. 13-18.][Christensen J. Traumatic brain injury: Risks of epilepsy and implications for medicolegal assessment // Epilepsia. 2012. № 53 (4). P. 43-47.][Covanis А. Epileptic encephalopathies (including severe epilepsy syndromes) // Epilepsia. 2012. № 53 (4). P. 114-126.][Hauptman J. S., Mathern G W. Surgical treatment of epilepsy associated with cortical dysplasia // Epilepsia. 2012. № 53 (4). P. 98-104.][Kübler A., Dixon V., Garavan H. Automaticity and reestablishment of executive control-an fMRI // J. Cogn Neurosci. 2006. № 18(8). P. 1331-1342.][Lüders H.O., Awad I. Conceptual considerations. In: Lüders H.O. editor Epilepsy surgery. New-York: raven Press, 1992. P. 51-62.][McDermott K.B., Petersen S.E., Watson J.M., Ojemann J.G. A procedure for identifying regions preferentially activated by attention to semantic and phonological relations using functional magnetic resonance imaging // Neuropsychologia. 2003. № 41(3). P. 293-303.][New A.S., Hazlett E.A., Newmark R.E., Zhang J.et al. Laboratory induced aggression: a positron emission tomography study of aggressive individuals with borderline personality disorder // Biol. Psychiatry. 2009. № 66(12). P. 1107-1114.][Potegal M. Temporal and frontal lobe initiation and regulation of the top-down escalation of anger and aggression // Behav. Brain Res. 2012. № 231(2). P. 386-395.][Talairach J., Tournoux P. Co-planar Stereotactic Atlas of the Human Brain: 3-Dimensional Proportional System: An Approach to Cerebral Imaging. 1988. Thieme New-York.][Theodore W.H. Imaging in epilepsy // Current science. 2002. № 82(6). P. 689-697.][Thompson E., Marrett C. Performance Evaluation of the PC-2048: A New 15-slice Encoded-Crystal PET Scanner for Neurological Studies // IEEE transactions on medical imaging. 1991. № 10(1). P. 90.]