Neurology BulletinNeurology Bulletin1027-48982304-3067Eco-Vector1397210.17816/nb13972Research ArticleCEREBRAL BLOOD FLOW IN WOMEN WITH PRIMARY HEADACHES AND ANTIPHOSPHOLIPID SYNDROMEGaynetdinovaDina DDepartment of Neurology, Neurosurgery and Medical genetics-TukhfatullinaSaniya IDepartment of Neurology, Neurosurgery and Medical geneticssonchik-525@yandex.ruKazan State Medical University15032016XLVIII1172420062019Copyright © 2016, Gaynetdinova D.D., Tukhfatullina S.I.201620 patients with headache (migraine - 7, tension headache -13) associated with hypercoagulable syndrome and 20 healthy women were screened. All patients underwent neurological and transcranialdoppler ultrasonography examinations. Transcranial Doppler ultrasonography measured increased parameters of cerebral blood flow in all patients with a headache associated with hypercoagulable syndrome. All the parameters were higher in elderly patients with primary antiphosholipid syndrome. A significant correlation between patient’s age and blood flow was found.antiphospholipid syndromeheadachehypercoagulabilityneurological manifestationsантифосфолипидный синдромголовная больгиперкоагуляцияневрологические проявления[Калашникова Л.А. Неишемические неврологические проявления у пациентов с первичным антифосфолипидным синдромом // Журнал неврологии и психиатрии им. Корсакова. 2005. № 105. С. 18-23.][Лелюк В.Г., Лелюк С.Е. Ультразвуковая ангиология. М: Реальное время, 2003.][Медик В.А., М.С. Токмачев. Математическая статистика в медицине. М.: Финансы и статистика, 2007.][Насонов Е.Л. Антифосфолипидный синдром. М.,2004.][Пономарева Е.Н., Синевич П.А., Пономарев В.В., А.И. Антоненко. Неврологические нарушения при антифосфолипидном синдроме // Неврологический журнал.2002. № 2. С. 22-24.][Archana D., Manish B., Bhavna S. Headache in pregnancy: a nuisance or a new sense? // Obstet. Gynecol. Int.2012. doi: 10.1155/2012/697697. http://www.hindawi.com/journals/ogi/2012/697697/ (дата обращения: 01.12.14).][Broder A., Tobin JN., Putterman C. High antiphospholipid antibody levels are associated with statin use and may reflect chronic endothelial damage in non-autoimmune thrombosis: cross-sectional study // Clin Pathol. 2012. № 65(6). Р. 551-556.][Carecchio M., Cantello R., Comi C. Revisiting the Molecular Mechanism of Neurological Manifestations in Antiphospholipid Syndrome: Beyond Vascular Damage // J. Immunol. Res. 2014. http://www.hindawi.com/journals/ gir/2014/239398/ (дата обращения: 01.12.14).][Gupta S., Zivadinov R., Ramasamy D., Ambrus J.L Jr. Reversible cerebral vasoconstriction syndrome (RCVS) in antiphospholipid antibody syndrome (APLA): the role of centrally acting vasodilators. Case series and review of literature // Clin Rheumatology. 2014. Dec., № 33(12). Р. 1829-1833.][Hughes, G. Migraine, memory loss, and «multiple sclerosis». Neurological features of the antiphospholipid (Hughes’) syndrome // Postgrad Med J. 2003. Vol. 79, № 928. Р. 81-83.][Meroni P.L., Raschi E., Testoni C. Endothelium as a target for antiphospholipid antibodies and for therapeutical intervention // Autoimmun Rev. 2002. № 1(1-2). Р. 55-60.][Nakashima M.O., Rogers H.J. Hypercoagulable states: an algorithmic approach to laboratory testing and update on monitoring of direct oral anticoagulants // Blood Res. 2014. Vol. 49, N 2. Р. 85-94.][Rand JH. The antiphospholipid syndrome // HematologyAm Soc Hematol Educ Program. 2007. № 1. P. 136-142.][The estimated frequency of antiphospholipid antibodies in young adults with cerebrovascular events: a systematic review/ S.Sciascia[et al.] // Ann Rheum Dis. 2014. Jun., № 18.]