Impact of anti-inflammatory therapy on the effects of photodynamic exposure in an experiment



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Abstract

A model of transplantable mouse sarcoma S-37 was used to show that the administration of anti-inflammatory drugs (ketonal and contrical) in therapeutic doses after photodynamic therapy (PDT) not only reduces the magnitude of photo-induced local tissue reactions, but may potentiate, in certain regimens, the therapeutic effect against the growth of primary tumor and metastases. The most signifiсant anti-tumor effect of PDT was observed when ketonal and contrical were coadministered twice 1 and 5 hours after light exposure. The study of the microvascular bed in the tumor growth area, by using immunohistochemistry with antibodies to the vascular endothelium (anti-CD31), has indicated that neovascularization processes are inhibited at the site of exposure when ketonal and contrical are given in the above regimen after PDT. The anti-inflammatory drug-potentiated antitumor effect of PDT is presumed to be caused by the inhibition of mediators of the exudative photo-induced nonspecific inflammation phase followed by delayed microvascular regenerative proliferation and prolonged injured tissue ischemia.

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