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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Current Pharmaceutical Design</journal-id><journal-title-group><journal-title xml:lang="en">Current Pharmaceutical Design</journal-title><trans-title-group xml:lang="ru"><trans-title>Current Pharmaceutical Design</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1381-6128</issn><issn publication-format="electronic">1873-4286</issn><publisher><publisher-name xml:lang="en">Bentham Science</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">645966</article-id><article-id pub-id-type="doi">10.2174/0113816128321020240903100601</article-id><article-categories><subj-group subj-group-type="toc-heading"><subject>Immunology, Inflammation &amp;amp; Allergy</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Anti-cancer Drug Targeting using Stimuli Sensitive Mesoporous Silica Nanoparticle in Colorectal Cancer</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Mainuddin</surname><given-names></given-names></name><email>info@benthamscience.net</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Kumar</surname><given-names>Anoop</given-names></name><email>info@benthamscience.net</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name><surname>Sharma</surname><given-names>Anjana</given-names></name><email>info@benthamscience.net</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name><surname>Sharma</surname><given-names>Nitin</given-names></name><email>info@benthamscience.net</email><xref ref-type="aff" rid="aff4"/></contrib></contrib-group><aff id="aff1"><institution>Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University</institution></aff><aff id="aff2"><institution>Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology</institution></aff><aff id="aff3"><institution>Department of Pharmaceutical Technology, Lloyd Institute of Management &amp; Technology</institution></aff><aff id="aff4"><institution>Department of Pharmaceutics, Amity Institute of Pharmacy,, Amity University</institution></aff><pub-date date-type="pub" iso-8601-date="2024-10-20" publication-format="electronic"><day>20</day><month>10</month><year>2024</year></pub-date><volume>30</volume><issue>39</issue><issue-title xml:lang="ru"/><fpage>3071</fpage><lpage>3073</lpage><history><date date-type="received" iso-8601-date="2025-01-11"><day>11</day><month>01</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Bentham Science Publishers</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Bentham Science Publishers</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://journals.eco-vector.com/1381-6128/article/view/645966">https://journals.eco-vector.com/1381-6128/article/view/645966</self-uri><abstract xml:lang="en"><p/></abstract><kwd-group xml:lang="en"><kwd>Colorectal cancer</kwd><kwd>mesoporous</kwd><kwd>stimuli sensitive</kwd><kwd>drug targeting</kwd><kwd>nanoparticles</kwd><kwd>nanomedicine.</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Rahmani F, Zandigohar M, Safavi P, et al. The interplay between noncoding RNAs and p21 signaling in gastrointestinal cancer: From tumorigenesis to metastasis. Curr Pharm Des 2023; 29(10): 766-76. doi: 10.2174/1381612829666230306123455 PMID: 36876835</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Sharma N, Kumari R, Karwasra R, Khanna K. Colon cancer and their targeting approaches through nanocarriers: A review. Asian Pac J Trop Biomed 2023; 13(3): 104-11. doi: 10.4103/2221-1691.372283</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Hofmann B. Ethical issues with colorectal cancer screening-a systematic review. J Eval Clin Pract 2017; 23(3): 631-41. doi: 10.1111/jep.12690 PMID: 28026076</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Marin JJ, Romero MR, Blazquez AG, Herraez E, Keck E, Briz O. Importance and limitations of chemotherapy among the available treatments for gastrointestinal tumours. Anticancer Agents Med Chem 2009; 9(2): 162-84. doi: 10.2174/187152009787313828</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Watermann A, Brieger J. Mesoporous silica nanoparticles as drug delivery vehicles in cancer. Nanomaterials (Basel) 2017; 7(7): 189. doi: 10.3390/nano7070189</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Meng J, Wang ZG, Zhao X, et al. Silica nanoparticle design for colorectal cancer treatment: Recent progress and clinical potential. World J Clin Oncol 2024; 15(6): 667-73. doi: 10.5306/wjco.v15.i6.667 PMID: 38946830</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Feng W, Zhou X, He C, et al. Polyelectrolyte multilayer functionalized mesoporous silica nanoparticles for pH-responsive drug delivery: Layer thickness-dependent release profiles and biocompatibility. J Mater Chem B Mater Biol Med 2013; 1(43): 5886-98. doi: 10.1039/c3tb21193b PMID: 32261055</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Baeza A, Colilla M, Vallet-Regí M. Advances in mesoporous silica nanoparticles for targeted stimuli-responsive drug delivery. Expert Opin Drug Deliv 2015; 12(2): 319-37. doi: 10.1517/17425247.2014.953051 PMID: 25421898</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Narayan R, Gadag S, Cheruku SP, et al. Chitosan-glucuronic acid conjugate coated mesoporous silica nanoparticles: A smart pH-responsive and receptor-targeted system for colorectal cancer therapy. Carbohydr Polym 2021; 261: 117893. doi: 10.1016/j.carbpol.2021.117893 PMID: 33766378</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Thirupathi K, Santhamoorthy M, Radhakrishnan S, et al. Thermosensitive polymer-modified mesoporous silica for pH and temperature-responsive drug delivery. Pharmaceutics 2023; 15(3): 795. doi: 10.3390/pharmaceutics15030795</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Zou Z, He X, He D, et al. Programmed packaging of mesoporous silica nanocarriers for matrix metalloprotease 2-triggered tumor targeting and release. Biomaterials 2015; 58: 35-45. doi: 10.1016/j.biomaterials.2015.04.034 PMID: 25941780</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Yang X, Liu X, Liu Z, Pu F, Ren J, Qu X. Near-infrared light-triggered, targeted drug delivery to cancer cells by aptamer gated nanovehicles. Adv Mater 2012; 24(21): 2890-5. doi: 10.1002/adma.201104797</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Al-Mosawi AKM, Bahrami AR, Nekooei S, Saljooghi AS, Matin MM. Using magnetic mesoporous silica nanoparticles armed with EpCAM aptamer as an efficient platform for specific delivery of 5-fluorouracil to colorectal cancer cells. Front Bioeng Biotechnol 2023; 10: 1095837.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Iranpour S, Bahrami AR, Nekooei S, Sh Saljooghi A, Matin MM. Improving anti-cancer drug delivery performance of magnetic mesoporous silica nanocarriers for more efficient colorectal cancer therapy. J Nanobiotechnol 2021; 19(1): 314. doi: 10.1186/s12951-021-01056-3 PMID: 34641857</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>He X, Zhao Y, He D, Wang K, Xu F, Tang J. ATP-responsive controlled release system using aptamer-functionalized mesoporous silica nanoparticles. Langmuir 2012; 28(35): 12909-15. doi: 10.1021/la302767b PMID: 22889263</mixed-citation></ref></ref-list></back></article>
