Current Pharmaceutical BiotechnologyCurrent Pharmaceutical BiotechnologyCurrent Pharmaceutical Biotechnology1389-20101873-4316Bentham Science64450110.2174/0113892010277968231127072017BiotechnologyResearch ArticleNavigating the Opioid Crisis: Exploring Innovative Approaches to Pain ManagementVermaAbhishekinfo@benthamscience.netChauhanAbhishekinfo@benthamscience.netIslamMdinfo@benthamscience.netKahlonMilaninfo@benthamscience.netSinghAmandeepinfo@benthamscience.netDepartment of Pharmaceutics,, ISF College of PharmacyDepartment of Pharmaceutics, ISF College of PharmacyPharmaceutics, ISF College of Pharmacypharmaceutics, ISF College of Pharmacy0107202425131629163107012025Copyright ©; 2024, Bentham Science Publishers2024Bentham Science Publishershttps://journals.eco-vector.com/1389-2010/article/view/644501[Dunlap, L.J.; Kuklinski, M.R.; Cowell, A.; McCollister, K.E.; Bowser, D.M.; Campbell, M.; Fernandes, C.S.F.; Kemburu, P.; Livingston, B.J.; Prosser, L.A.; Rao, V.; Smart, R.; Yilmazer, T. Economic evaluation design within the HEAL prevention cooperative. Prev. Sci., 2023, 24(Suppl. 1), 50-60. doi: 10.1007/s11121-022-01400-5 PMID: 35947282][Bruera, E.; Del Fabbro, E. Pain management in the era of the opioid crisis. Am. Soc. Clin. Oncol. Educ. Book, 2018, 38, 807-812. doi: 10.1200/EDBK_208563][Davenport, T.E.; DeVoght, A.C.; Sisneros, H.; Bezruchka, S. Navigating the intersection between persistent pain and the opioid crisis: Population health perspectives for physical therapy. Phys. Ther., 2020, 100(6), 995-1007. doi: 10.1093/ptj/pzaa031 PMID: 32115638][Siracusa, R.; Paola, R.D.; Cuzzocrea, S.; Impellizzeri, D. Fibromyalgia: Pathogenesis, mechanisms, diagnosis and treatment options update. Int. J. Mol. Sci., 2021, 22(8), 3891. doi: 10.3390/ijms22083891 PMID: 33918736][Joshi, G.P.; Van de Velde, M.; Kehlet, H. Development of evidence‐based recommendations for procedure‐specific pain management: PROSPECT methodology. Anaesthesia, 2019, 74(10), 1298-1304. doi: 10.1111/anae.14776 PMID: 31292953][Rose, M.E. Are prescription opioids driving the opioid crisis? Assumptions vs facts. Pain Med., 2018, 19(4), 793-807. doi: 10.1093/pm/pnx048 PMID: 28402482][Trends & Statistics Available from: https://nida.nih.gov/research-topics/trends-statistics/overdose-death-rates][Othman, M.; Jones, L.; Neilson, J.P. Non‐opioid drugs for pain management in labour. Cochrane Database Syst. Rev., 2012, 7, CD009223. doi: 10.1002/14651858.CD009223.pub2][Tauben, D. Nonopioid medications for pain. Phys. Med. Rehabil. Clin. N. Am., 2015, 26(2), 219-248. doi: 10.1016/j.pmr.2015.01.005 PMID: 25952062][Jones, M.R.; Viswanath, O.; Peck, J.; Kaye, A.D.; Gill, J.S.; Simopoulos, T.T. A brief history of the opioid epidemic and strategies for pain medicine. Pain Ther., 2018, 7(1), 13-21. doi: 10.1007/s40122-018-0097-6 PMID: 29691801][Reid, M.C.; Bennett, D.A.; Chen, W.G.; Eldadah, B.A.; Farrar, J.T.; Ferrell, B.; Gallagher, R.M.; Hanlon, J.T.; Herr, K.; Horn, S.D.; Inturrisi, C.E.; Lemtouni, S.; Lin, Y.W.; Michaud, K.; Morrison, R.S.; Neogi, T.; Porter, L.L.; Solomon, D.H.; Von Korff, M.; Weiss, K.; Witter, J.; Zacharoff, K.L. Improving the pharmacologic management of pain in older adults: Identifying the research gaps and methods to address them. Pain Med., 2011, 12(9), 1336-1357. doi: 10.1111/j.1526-4637.2011.01211.x PMID: 21834914][Coluzzi, F.; Bifulco, F.; Cuomo, A.; Dauri, M.; Leonardi, C.; Melotti, R.M.; Natoli, S.; Romualdi, P.; Savoia, G.; Corcione, A. The challenge of perioperative pain management in opioid-tolerant patients. Ther. Clin. Risk Manag., 2017, 13, 1163-1173. doi: 10.2147/TCRM.S141332 PMID: 28919771][Huxtable, C.A.; Roberts, L.J.; Somogyi, A.A.; Macintyre, P.E. Acute pain management in opioid-tolerant patients: A growing challenge. Anaesth. Intensive Care, 2011, 39(5), 804-823. doi: 10.1177/0310057X1103900505 PMID: 21970125][Krashin, D.; Murinova, N.; Sullivan, M. Challenges to treatment of chronic pain and addiction during the "opioid crisis". Curr. Pain Headache Rep., 2016, 20(12), 65. doi: 10.1007/s11916-016-0596-2 PMID: 27873121][Hui, D.; Bruera, E. A personalized approach to assessing and managing pain in patients with cancer. J. Clin. Oncol., 2014, 32(16), 1640-1646. doi: 10.1200/JCO.2013.52.2508 PMID: 24799495]