Current Protein & Peptide ScienceCurrent Protein & Peptide ScienceCurrent Protein & Peptide Science1389-20371875-5550Bentham Science64552810.2174/1389203724666230915123217Life SciencesResearch ArticleARL15 and its Multiple Disease Association: Emerging Functions and Potential Therapeutic ApplicationSainiManishainfo@benthamscience.netAnandVarnitainfo@benthamscience.netSharmaAdityainfo@benthamscience.netPandeyAnujinfo@benthamscience.netThelmaBittiandainfo@benthamscience.netKunduSumaninfo@benthamscience.netDepartment of Biochemistry, University of Delhi South CampusDepartment of Genetics,, University of Delhi South CampusDepartment of Genetics, University of Delhi South Campus0102202425213715311012025Copyright ©; 2024, Bentham Science Publishers2024Bentham Science Publishershttps://journals.eco-vector.com/1389-2037/article/view/645528

ARL15 is a member of the RAS superfamily of small GTPases and is associated with several metabolic traits, including increased risk of diabetes, rheumatoid arthritis and lipid metabolism disorders. The ARL15 gene encodes for an uncharacterized small GTP binding protein. Its precise role in human physiology remains unknown, but several genetic association studies have recognized different variants in this gene to be statistically associated with numerous traits and complex diseases. Here, we provided the unique features of ARL15 small G protein, its association with varied metabolic and lifestyle diseases, its function in vesicular and lipid trafficking, and its binding partners. We outlined this protein as a promising and emerging therapeutic target to combat metabolic disorders like cardiovascular diseases, diabetes and rheumatoid arthritis. The review provides a comprehensive description of the current advancements in ARL15 research with a perspective that focused research will position this small GTPase as a viable target for the treatment of rheumatoid arthritis.

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