Adaptivnaya immunoterapiya T-kletochnykh limfom kozhi na osnove ekstrakorporal'nogo fotofereza

Abstract


The paper describes the first clinical experience in using the improved immunotherapeutic method of treating cutaneous T-cell lymphomas, which is based on extracorporeal photochemotherapy (photopheresis), followed by a 20-hour incubation period. The distinctive feature of this method is to differentiate monocytes into dendritic cells (DC) ex vivo without exogenically applying of growth factors, as suggested by the increase of CD14+ cells that express the coactivation molecule B7.2 (CD86).
It is shown that 20-hour incubation gives rise to at least two potentially important cellular mechanisms to generate an adequate antitumor immune response. On the one hand, this is apoptosis of leukemic T cells and necrotic destruction of mature nonfunctional DCs that contain a full range of tumor antigens to yield exosomes and to convert antigenic epitopes to their soluble form. On the other hand, the activated monocytes that are initiated by transforming to dendritic antigen-presenting cells that are capable of the endocytosis of exosomes and the phagocytosis of apoptotic malignant cells, the processing and presentation of their distinguishing antigens by T-cell receptors on the naive T lymphocytes.

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Copyright (c) 2010 Kil'dyushevskiy A.V., Molochkov V.A., Ol'shanskiy A.Y., Molochkov A.V., Fomin A.M., Gordievskaya M.S., Karzanov O.V., Petrenko E.V.

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