GENE METHYLATION IN CD3+ CELLS IN PSORIASIS

Abstract


Gene methylation level in CD3+ cells of psoriasis patients in comparison with that in normal subjects was analyzed using Illumina microchips. Differentially methylated locuses were detected in CD3+ cells of psoriasis patients and normal subjects. FRK, JAK1, AKAP7, DYRK1A, PRKCA, RPS6KA2 kinase genes were detected in the most methylated locuses in CD3+ cells of psoriasis patients. The clear-cut separation of the samples into two groups suggested that the level of the studied genes methylation in CD3+ cells can serve for predicting liability to psoriasis and presumably for diagnosis of its early stages.

Full Text

Метилирование генов в CD3+-клетках при псориазе

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Copyright (c) 2013 Sobolev V.V., Denisova E.V., Soboleva A.G., Korsunskaya I.M., Chekalin E.V., Zolotarenko A.D., Bruskin S.A.

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