Vliyanie eksimernogo lazera na gistologicheskie i immunogistokhimicheskie izmeneniya pri gnezdnoy alopetsii

The purpose of research is to investigate the histological and immunohistochemical alterations by the impact of the excimer laser in patients with circumscribed alopecia. The examination included 180 patients aged from 18 to 46 years suffering circumscribed alopecia (81 males (45%) and 99 females (55%)). The length of disease consisted from 2 to 16 years. The phototherapy using the excimer laser with wavelength 308 nm permitted to achieve clinical remission in 134 patients (74.4%). The histological and immunohistochemical alterations of the skin affected by circumscribed alopecia are examined. It is shown that in the development of pathological process T-cell component of immunity is involved. The phototherapy inhibits the T-cells activation being pathogenetically proved treatment of circumscribed alopecia.

circumscribed alopecia, excimer laser, histological and immunohistochemical alterations